Lysine (K)-Specific Demethylase 1A (KDM1A) antibody

Details for Product No. ABIN969264
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Antigen
Synonyms
KDM1, AOF2, KDM1A, DKFZp459N2450, aof2, kdm1, lsd1, xLSD1, BHC110, LSD1, 1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601, RGD1562975, wu:fb82e06, wu:fc51a02, wu:fj36a05, wu:fj66b06, A ... show more
KDM1, AOF2, KDM1A, DKFZp459N2450, aof2, kdm1, lsd1, xLSD1, BHC110, LSD1, 1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601, RGD1562975, wu:fb82e06, wu:fc51a02, wu:fj36a05, wu:fj66b06, ARABIDOPSIS LYSINE-SPECIFIC HISTONE DEMETHYLASE, ATLSD1, ATSWP1, F23N19.21, F23N19_21, LSD1-like 1, LYSINE-SPECIFIC HISTONE DEMETHYLASE, SWP1 show less
Reactivity
Human, Mouse (Murine), Monkey
(134), (67), (59), (31), (26), (25), (24), (11), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(107), (30), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(116), (44), (40), (29), (20), (16), (9), (7), (6), (4), (4), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 100 μL
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Catalog No. ABIN969264
341.00 $
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Immunogen Purified recombinant fragment of human LSD1 expressed in E. coli.
Clone 1B2E5
Isotype IgG1
Purification Ascites
Alternative Name LSD1/AOF2
Background Synonyms:
kDaM1, LSD1, AOF2
The amine oxidase domain 2 (AOF2) gene encodes a nuclear protein (LSD1, approx. 95 kDa) containing a Swirm domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. LSD1 is a chromatin-modifying enzyme, which serve as a docking module for the stabilization of the associated corepressor complex (es) on chromatin.
Molecular Weight 93 kDa
Gene ID 23028
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody Figure 2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma (left) and kidney carcinoma (right), showing nuclear localization using LSD1 mouse mAb with DAB staining.
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) antibody (2) Figure 1: Western blot analysis using LSD1 mouse mAb against COS (1), Hela (2), NIH/3T3 (3), A549 (4) and Jurkat (5) cell lysate.
Product cited in: Metzger, Wissmann, Yin et al.: "LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription." in: Nature, Vol. 437, Issue 7057, pp. 436-9, 2005 (PubMed).

Shi, Matson, Lan et al.: "Regulation of LSD1 histone demethylase activity by its associated factors." in: Molecular cell, Vol. 19, Issue 6, pp. 857-64, 2005 (PubMed).

Validation Images
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