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Details for Product No. ABIN969274

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (AA 400-500) antibody

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Antigen
Synonyms FLH21957, HGK, MEKKK4, NIK, 9430080K19Rik, AU043147, AU045934, AW046177, Nik
Epitope
»Alternatives AA 400-500
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN969274
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of MAP4K4 (AA 400-500) expressed in E. coli.
Clone 4H9E7
Isotype IgG1
Purification Ascites
Alternative Name MAP4K4
Background Synonyms:
HGK, NIK
MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-α signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID 9448
Research Area Signaling
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Becker, Huynh-Do, Holland et al.: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, 2000 (PubMed).

Poinat, De Arcangelis, Sookhareea et al.: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, 2002 (PubMed).

Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, 2007 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4)", type "Antibodies"
Hosts (94), (25)
Reactivities (118), (63), (51), (49), (48), (13), (13), (1), (1), (1)
Applications (65), (47), (40), (25), (10), (9), (3), (3), (1), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (16), (15), (12), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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