You are viewing an incomplete version of our website. Please click to reload the website as full version.

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (AA 400-500) antibody

Details for Product No. ABIN969275, Supplier: Login to see
Antigen
  • FLH21957
  • HGK
  • MEKKK4
  • NIK
  • 9430080K19Rik
  • AU043147
  • AU045934
  • AW046177
  • Nik
Epitope
AA 400-500
31
21
15
14
13
10
10
7
7
6
6
6
6
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
147
44
25
2
2
2
1
1
1
Host
Mouse
126
29
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
8
8
7
7
7
4
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
93
83
36
18
16
14
10
5
4
3
2
1
Supplier
Login to see
Supplier Product No.
Login to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen Purified recombinant fragment of MAP4K4 (AA 400-500) expressed in E. coli.
Clone 3C7B5
Isotype IgG1
Purification Ascites
Alternative Name MAP4K4 (MAP4K4 Antibody Abstract)
Background MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID 9448
HGNC 9448
Research Area Signaling
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (AA 400-500) antibody (ABIN969275) Figure 1: Western blot analysis using MAP4K4 mouse mAb against truncated Trx-MAP4K4 r...
Product cited in: Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, 2007 (PubMed).

Poinat, De Arcangelis, Sookhareea et al.: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, 2002 (PubMed).

Becker, Huynh-Do, Holland et al.: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, 2000 (PubMed).