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Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) antibody

Details for Product No. ABIN969302, Supplier: Login to see
Antigen
  • 2410014J02Rik
  • MLC-2
  • Mlc2
  • CMH10
  • MLC2
  • Mlc-2
  • myosin
  • regulatory
  • MLC-2v
  • Mlc2v
  • Mylpc
Reactivity
Human
73
19
18
3
1
1
1
1
Host
Mouse
40
39
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
Application
ELISA, Western Blotting (WB)
66
41
22
15
11
6
2
2
2
2
Supplier
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Immunogen Purified recombinant fragment of MYL2 expressed in E. coli.
Clone 7C9
Isotype IgG1
Purification Ascites
Alternative Name MYL2 (MYL2 Antibody Abstract)
Background MYL2(myosin, light chain 2, regulatory, cardiac, slow), also known as MLC-2, MLC2v. Entrez protein NP_000423. MYL2 associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. It is an hexamer of two heavy chains and four light chains that is predominantly expressed in adult cardiac ventricle muscle. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Molecular Weight 19 kDa
Gene ID 4633
HGNC 4633
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) antibody (ABIN969302) Figure 1: Western blot analysis using MYL3 (1) and MYL2 (2) mouse mAb against rat fet...
Product cited in: Sachdev, Raychowdhury, Sarkar: "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 14, Issue 5, pp. 339-50, 2004 (PubMed).

Ueda, Murata-Hori, Tatsuka et al.: "Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells." in: Oncogene, Vol. 21, Issue 38, pp. 5852-60, 2002 (PubMed).