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Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) antibody

Details for Product No. ABIN969360, Supplier: Login to see
Antigen
  • ppp1a
  • Ppp1c
  • dism2
  • wu:fc04c08
  • wu:fc09b07
  • wu:fc30g11
  • wu:fe05h08
  • zgc:85729
  • PP-1A
  • PP1A
  • PP1alpha
  • PPP1A
  • 2310003C21Rik
  • 2900017D14Rik
  • AI427932
  • AU017636
  • MMPa-2
  • MPPa-1
  • PP2C-ALPHA
  • PP2CA
  • PP2Calpha
Reactivity
Human
101
40
34
12
7
3
3
Host
Mouse
52
51
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
Application
ELISA, Western Blotting (WB)
89
45
27
13
13
12
11
4
3
1
Supplier
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Immunogen Purified recombinant fragment of human PPP1CA expressed in E. coli.
Clone 5-00E-09
Isotype IgG1
Purification Ascites
Alternative Name PPP1CA (PPP1CA Antibody Abstract)
Background The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 38 kDa
Gene ID 5499
HGNC 5499
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
ELISA image for anti-Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) antibody (ABIN969360) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Western Blotting (WB) image for anti-Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) antibody (ABIN969360) Figure 2: Western blot analysis using PPP1CA mouse mAb against Hela (1), HepG2 (2), M...
Western Blotting (WB) image for anti-Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) antibody (ABIN969360) Figure 3: Western blot analysis using PPP1CA mAb against human PPP1CA (AA: 174-330) r...
Product cited in: Chen, Kesler, Paschal et al.: "Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1." in: The Journal of biological chemistry, Vol. 284, Issue 38, pp. 25576-84, 2009 (PubMed).

Perry, Yang, Soora et al.: "Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression." in: Molecular and cellular biology, Vol. 29, Issue 12, pp. 3355-66, 2009 (PubMed).