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Details for Product No. ABIN969360

Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) antibody

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Antigen
Synonyms PP-1A, PP1A, PP1alpha, PPP1A, Ppp1c, dism2, ppp1a
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN969360
Quantity 100 µL
Price
396.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human PPP1CA expressed in E. coli.
Clone 5-00E-09
Isotype IgG1
Purification Ascites
Alternative Name PPP1CA
Background Synonyms:
PP-1A, PPP1A, PP1α
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen mηbolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 38 kDa
Gene ID 5499
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Perry, Yang, Soora et al.: "Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression." in: Molecular and cellular biology, Vol. 29, Issue 12, pp. 3355-66, 2009 (PubMed).

Chen, Kesler, Paschal et al.: "Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1." in: The Journal of biological chemistry, Vol. 284, Issue 38, pp. 25576-84, 2009 (PubMed).

Alternatives for antigen "Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA)", type "Antibodies"
Hosts (46), (30), (2), (1)
Reactivities (79), (36), (32), (7), (4), (2), (1), (1), (1), (1)
Applications (75), (47), (15), (12), (10), (6), (6), (3)
Epitopes (12), (10), (7), (5), (2), (2), (1), (1), (1)
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