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Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA) antibody
|Synonyms||PP-1A, PPP1A, MGC1674, MGC15877, Ppp1c, dism2, ppp1a, MGC52704, PPP1CA, MGC127348|
Alternatives ELISA, Western Blotting (WB)
|2 references available|
|Price||396.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 3 to 4 Business Days|
|Immunogen||Purified recombinant fragment of human PPP1CA expressed in E. Coli.|
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: PP-1A, PPP1A, PP1alpha
Western Blotting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Buffer||Ascitic fluid containing 0.03% sodium azide.|
|Preservative||0.03% sodium azide|
|Storage||Store at 4℃, for long term storage, store at -20℃.|
|Restrictions||For Research Use only|
Perry, Yang, Soora et al.: "Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression." in: Molecular and cellular biology, Vol. 29, Issue 12, pp. 3355-66, 2009 (PubMed).
Chen, Kesler, Paschal et al.: "Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1." in: The Journal of biological chemistry, Vol. 284, Issue 38, pp. 25576-84, 2009 (PubMed).
|Hosts||Rabbit (30), Mouse (13), Chicken (1), Sheep (1)|
|Reactivities||Human (45), Rat (Rattus) (17), Mouse (Murine) (16), Cow (Bovine) (4), Rabbit (3), Dog (Canine) (1), Pig (Porcine) (1)|
|Applications||Western Blotting (WB) (45), ELISA (26), Immunohistochemistry (IHC) (8), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunoprecipitation (IP) (6), Immunocytochemistry (ICC) (3), Immunofluorescence (IF) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)|
|Epitopes||C-Term (7), N-Term (4), AA 30-299 (3), pThr320,C-Term (3), pThr320 (2), AA 316-330 (1), AA 317-330 (1), AA 319-329 (1)|