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Details for Product No. ABIN969370

PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody

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Antigen
Synonyms LEDGF/p75, DFS70, LEDGF, PAIP, PSIP2, p52, p75, Dfs70, Psip2, Ledgfa, Ledgfb, AA408851, AU015605, Ledgf, SBP75, PSIP1, im:7149861, zgc:109898
Reactivity
»Alternatives Human, Monkey, Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Pubmed 1 reference available
Catalog no. ABIN969370
Quantity 100 µL
Price
407.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human PSIP1 expressed in E. coli.
Clone 6-00E-04
Isotype IgG1
Purification Ascites
Alternative Name PSIP1
Background Synonyms:
p52, p75, PAIP, DFS70, LEDGF, PSIP2, MGC74712, PSIP1
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fηl and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fηl as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fηl brain, expressed in the germinal neuroepithelium and cortical plate regions.
Molecular Weight 75 kDa
Gene ID 11168
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Shun, Botbol, Li et al.: "Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity." in: Journal of virology, Vol. 82, Issue 23, pp. 11555-67, 2008 (PubMed).

Alternatives for antigen "PC4 and SFRS1 Interacting Protein 1 (PSIP1)", type "Antibodies"
Hosts (12), (8), (1)
Reactivities (21), (7), (4), (4), (3), (3), (1)
Applications (20), (8), (4), (4), (4), (3), (2)
Epitopes (3), (3), (2), (2), (2)
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