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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody
|Synonyms||p52, p75, PAIP, DFS70, LEDGF, PSIP2, MGC74712, Dfs70, Psip2, Ledgfa, Ledgfb, AA408851, AU015605, PSIP1, Ledgf, LEDGF/p75, MGC109898, zgc:109898|
Human, Monkey, Rat (Rattus)
Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
|1 reference available|
|Price||407.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 3 to 4 Business Days|
|Immunogen||Purified recombinant fragment of human PSIP1 expressed in E. Coli.|
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
Synonyms: p52, p75, PAIP, DFS70, LEDGF, PSIP2, MGC74712, PSIP1
Western Blotting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Buffer||Ascitic fluid containing 0.03% sodium azide.|
|Preservative||0.03% sodium azide|
|Storage||Store at 4℃, for long term storage, store at -20℃.|
|Research Area||Chromatin and Nuclear Signaling, Transcription Factors|
|Restrictions||For Research Use only|
Shun, Botbol, Li et al.: "Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity." in: Journal of virology, Vol. 82, Issue 23, pp. 11555-67, 2008 (PubMed).
|Hosts||Rabbit (15), Mouse (4), Goat (1)|
|Reactivities||Human (20), Rat (Rattus) (6), Dog (Canine) (4), Mouse (Murine) (4), Cow (Bovine) (3), Monkey (2), Chicken (1)|
|Applications||Western Blotting (WB) (20), ELISA (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunofluorescence (IF) (2), Immunoprecipitation (IP) (2), Immunocytochemistry (ICC) (1), Immunohistochemistry (IHC) (1)|
|Epitopes||C-Term (3), Internal Region (3), AA 225-275 (2), Center (2), N-Term (1)|