PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody

Details for Product No. ABIN969370
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Antigen
Synonyms PSIP1, im:7149861, zgc:109898, LEDGF, p75, PSIP2, DFS70, PAIP, p52, AA408851, AU015605, Dfs70, Ledgfa, Ledgfb, Psip2, Ledgf, SBP75, LEDGF/p75
Reactivity
Human, Monkey, Rat (Rattus)
(29), (10), (5), (5), (4), (3), (1)
Host
Mouse
(16), (14), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
(30), (17), (11), (8), (7), (6), (4), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μL
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Catalog No. ABIN969370
407.00 $
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Immunogen Purified recombinant fragment of human PSIP1 expressed in E. coli.
Clone 6-00E-04
Isotype IgG1
Purification Ascites
Alternative Name PSIP1
Background Synonyms:
p52, p75, PAIP, DFS70, LEDGF, PSIP2, MGC74712, PSIP1
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fηl and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fηl as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fηl brain, expressed in the germinal neuroepithelium and cortical plate regions.
Molecular Weight 75 kDa
Gene ID 11168
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (2) Figure 4: Immunofluorescence analysis of NIH/3T3 cells using PSIP1 mouse mAb (green) . Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (3) Figure 3: Immunohistochemical analysis of paraffin-embedded lung cancer tissues (left) and brain tissues (right) using PSIP1 mouse mAb with DAB staining.
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (4) Figure 2: Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and ovarian cancer tissues (right) using PSIP1 mouse mAb with DAB staining.
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (5) Figure 1: Western blot analysis using PSIP1 mouse mAb against HepG2 (1), Jurkat (2), K562 (3), Cos7 (4), PC-12 (5), Hela (6), and NIH/3T3 (7) cell lysate.
Product cited in: Shun, Botbol, Li et al.: "Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity." in: Journal of virology, Vol. 82, Issue 23, pp. 11555-67, 2008 (PubMed).

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