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Metadherin (MTDH) antibody

Details for Product No. ABIN969496
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Antigen
Synonyms 2610103J23Rik, 3D3, 3D3/Lyric, AEG-1, AV353288, D8Bwg1112e, Lyric, AEG1, LYRIC, LYRIC/3D3, MGC75963
Reactivity
Human
(43), (15), (14), (12), (12), (12), (1)
Host
Mouse
(30), (12)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
(32), (20), (16), (10), (9), (7), (5), (4), (4), (1), (1), (1)
Pubmed 1 reference available
Quantity 100 µL
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Shipping to United States (Change)
Availability Will be delivered in 3 to 4 Business Days
Catalog No. ABIN969496
363.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of human Metadherin expressed in E. coli.
Clone 2F11C3
Isotype IgG1
Purification Purified by protein G affinity chromatography
Alternative Name Metadherin
Background Synonyms:
3D3, AEG1, LYRIC, MTDH
Mηdherin (Mηstasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Mηdherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Mηdherin binds to lung vasculature, one of the four common sites of breast cancer mηstasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting mηdherin with siRNA has been reported to inhibit breast cancer mηstasis.
Molecular Weight 64 kDa
Gene ID 92140
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 50 % glycerol and 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Metadherin (MTDH) antibody Figure 3: Flow cytometric analysis of Hela cells using Metadherin mouse mAb (green) and negative control (purple) .
anti-Metadherin (MTDH) antibody (2) Figure 2: Immunohistochemical analysis of paraffin-embedded human Liver tissues using Metadherin mouse mAb
anti-Metadherin (MTDH) antibody (3) Figure 1: Western blot analysis using Metadherin mouse mAb against K562 (1), SKBR-3 (2), T47D (3), Hela (4) and MCF-7 (5) cell lysate.
Product cited in: Britt, Yang, Yang et al.: "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells." in: Experimental cell research, Vol. 300, Issue 1, pp. 134-48, 2004 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN969496
363.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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