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Details for Product No. ABIN969496

Metadherin (MTDH) antibody

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Antigen
Synonyms 2610103J23Rik, 3D3, 3D3/Lyric, AEG-1, AV353288, D8Bwg1112e, Lyric, AEG1, LYRIC, LYRIC/3D3, MGC75963
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
Pubmed 1 reference available
Catalog no. ABIN969496
Quantity 100 µL
Price
363.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human Metadherin expressed in E. coli.
Clone 2F11C3
Isotype IgG1
Purification Purified by protein G affinity chromatography
Alternative Name Metadherin
Background Synonyms:
3D3, AEG1, LYRIC, MTDH
Mηdherin (Mηstasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Mηdherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Mηdherin binds to lung vasculature, one of the four common sites of breast cancer mηstasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting mηdherin with siRNA has been reported to inhibit breast cancer mηstasis.
Molecular Weight 64 kDa
Gene ID 92140
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 50 % glycerol and 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Britt, Yang, Yang et al.: "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells." in: Experimental cell research, Vol. 300, Issue 1, pp. 134-48, 2004 (PubMed).

Alternatives for antigen "Metadherin (MTDH)", type "Antibodies"
Hosts (24), (10)
Reactivities (35), (14), (14), (12), (12), (12)
Applications (25), (20), (14), (10), (8), (8), (3), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (1)
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