ASK1 antibody
Quick Overview for ASK1 antibody (ABIN187833)
Target
See all ASK1 (MAP3K5) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Specificity
- This antibody detects ASK1. Species Reactivity: Human, other species not tested.
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Immunogen
- Synthetic peptide corresponding to amino acids 1356 to 1375 of human ASK1 protein.
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anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (pThr845) antibody
MAP3K5 Reactivity: Human, Mouse, Rat, Cow WB, ELISA, IHC (p), FACS Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibodyMAP3K5 Reactivity: Human IHC, ELISA, ICC, FACS Host: Mouse Monoclonal 2E4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 1231-1374) antibodyMAP3K5 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 2D11 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (pSer966) antibodyMAP3K5 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 693-933) antibodyMAP3K5 Reactivity: Mouse WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 821-849) antibodyMAP3K5 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB12839 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (AA 1231-1374) antibodyMAP3K5 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1E3 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (C-Term) antibodyMAP3K5 Reactivity: Human, Mouse WB, IHC, ELISA, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (pSer83) antibodyMAP3K5 Reactivity: Human WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) (N-Term) antibodyMAP3K5 Reactivity: Human, Mouse WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
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Application Notes
- Western blot: Use 0.5-1 µg/ml. Detects a 155 kDa band in SW1353 whole cell lysate. The optimal dilution for a specific application should be determined by the researcher. Note: immunogen sequence differs in mouse by last two amino acids.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Provided at 0.5 mg/ml in PBS solution containing 0.02% sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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- ASK1 (MAP3K5) (Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
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Alternative Name
- MEKK5 / ASK1
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Background
- Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activate c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induces apoptotic cell death, and a catalytically inactive form of ASK1 inhibit TNF-alpha-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
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Pathways
- MAPK Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
Target
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