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DNMT3L antibody (AA 152-164)

Name: DNMT3L antibody (AA 152-164)
SKU: ABIN118012
Availability: InStock

This Rabbit Polyclonal antibody specifically detects DNMT3L in WB, IP and EIA. It exhibits reactivity toward Human and Mouse.

Immunoblotting. (DNMT3L antibody (AA 152-164))

Schematic representation of the Dnmt3 family members. (DNMT3L antibody (AA 152-164))

2 images

Catalog No. ABIN118012

$1,116.00

Plus shipping costs $50.00

0.1 mg

Shipping to: United States

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Quick Overview for DNMT3L antibody (AA 152-164) (ABIN118012)

Target

See all DNMT3L (TRDMT1) Antibodies

DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Reactivity

Human, Mouse

Host

Rabbit

Clonality

Polyclonal

Conjugate

This DNMT3L antibody is un-conjugated

Application

Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

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Binding Specificity
15

8

7

7

6

5

5

5

2

2

2

2

1

1

1

1

1

1

1

1
AA 152-164

Sequence

Peptide: G-L-L-Q-R-R-R-K-W-R-S-Q-L Protein: 1 maaipaldpe aepsmdvilv gsselsssvs pgtgrdliay evkanqrnie diciccgslq 61 vhtqhplfeg gicapckdkf ldalflyddd gyqsycsicc sgetllicgn pdctrcycfe 121 cvdslvgpgt sgkvhamsnw vcylclpssr sgllqrrrkw rsqlkafydr esenplemfe 181 tvpvwrrqpv rvlslfedik keltslgfle sgsdpgqlkh vvdvtdtvrk dveewgpfdl 241 vygatpplgh tcdrppswyl fqfhrllqya rpkpgspgpf fwmfvdnlvl nkedldvasr 301 flemepvtip dvhggslqna vrvwsnipai rsrhwalvse eelsllaqnk qssklaakwp 361 tklvkncflp lreyfkyfst eltssl

Specificity

This antibody reacts with DNMT3L.

Cross-Reactivity (Details)

Species reactivity (expected):Mouse (76 %).
Species reactivity (tested):Human.

Purification

Immunoaffinity Chromatography using the immunizing peptide after immobilization to a solid phase

Immunogen

A synthetic peptide corresponding to aa 152-164 of Human DNMT3L.
anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 1-386) antibody
TRDMT1 Reactivity: Human WB, IF, IP Host: Rabbit Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 147-386) antibody
TRDMT1 Reactivity: Human ELISA, FACS Host: Mouse Monoclonal 2D10H11 unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) antibody
TRDMT1 Reactivity: Human, Mouse, Rat IHC, IF Host: Rabbit Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (Internal Region) antibody
TRDMT1 Reactivity: Human, Mouse WB, ELISA, IHC, IF, ICC, IP, ChIP Host: Rabbit Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 357-388), (C-Term) antibody
TRDMT1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB02219 unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 1-386) antibody
TRDMT1 Reactivity: Human WB Host: Mouse Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 1-234) antibody
TRDMT1 Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 389-421) antibody
TRDMT1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB2393 unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 150-175) antibody
TRDMT1 Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated

anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) (AA 258-290) antibody
TRDMT1 Reactivity: Mouse WB Host: Rabbit Polyclonal RB50994 unconjugated

Application Notes

This product has been assayed by ELISA, Western blotting and Immunoprecipitation. The antibody was tested by ELISA against 0.1 μg of the immunizing peptide. A1/1,000-1/3,000 dilution of the antibody is recommended for this assay. For Western blotting, first Immunoprecipitate (1/100 dilution) the antigen using this

Restrictions

For Research Use only
Concentration

1.43 mg/mL (by UV absorbance at 280 nm)

Buffer

0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, containing 0.01 % (w/v) Sodium Azide as preservative.

Preservative

Sodium azide

Precaution of Use

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Avoid repeated freezing and thawing. Shelf live: One year from despatch.

Storage

4 °C/-20 °C

Storage Comment

Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Should this product contain a precipitate we recommend microcentrifugation before use.
Target

DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Alternative Name

DNMT3L

Background

DNMT 3L is a nuclear protein that has similarity to DNA methyltransferases, involved in de novo methylation of CpG islands. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1.Synonyms: DNA (cytosine-5)-methyltransferase 3-like

Gene ID

29947

NCBI Accession

NP_037501

UniProt

Q9UJW3