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anti-Human PCK1 Antibodies:
anti-Rat (Rattus) PCK1 Antibodies:
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Human Polyclonal PCK1 Primary Antibody for IF, IHC (p) - ABIN1882180
OBrien, Printz, Halmi, Tiesinga, Granner: Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter. in Biochimica et biophysica acta 1996
Show all 8 Pubmed References
Human Polyclonal PCK1 Primary Antibody for ELISA, WB - ABIN253098
Willer, Bonnycastle, Conneely, Duren, Jackson, Scott, Narisu, Chines, Skol, Stringham, Petrie, Erdos, Swift, Enloe, Sprau, Smith, Tong, Doheny, Pugh, Watanabe, Buchanan, Valle, Bergman, Tuomilehto et al.: Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. ... in Diabetes 2006
Human Polyclonal PCK1 Primary Antibody for IF (p), IHC (p) - ABIN708191
Wong, Sun, Trudel, Sebastiani, Laneuville: Temporal gene expression profiling of the rat knee joint capsule during immobilization-induced joint contractures. in BMC musculoskeletal disorders 2015
Human Polyclonal PCK1 Primary Antibody for IHC (p), IHC - ABIN250970
Yang, Graham, Mody, Preitner, Peroni, Zabolotny, Kotani, Quadro, Kahn: Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. in Nature 2005
Human Monoclonal PCK1 Primary Antibody for IF, IP - ABIN562129
Cicerchi, Li, Kratzer, Garcia, Roncal-Jimenez, Tanabe, Hunter, Rivard, Sautin, Gaucher, Johnson, Lanaspa: Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014
Cow (Bovine) Polyclonal PCK1 Primary Antibody for WB - ABIN2777602
Chakravarty, Wu, Chiang, Samols, Hanson: SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. in The Journal of biological chemistry 2004
Show all 2 Pubmed References
Human Polyclonal PCK1 Primary Antibody for IHC, IHC (p) - ABIN4344079
Tao, Zhang, Zeng, Shulman, Jin: Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. in Nature medicine 2014
Arabidopsis uses two gluconeogenic gateways for organic acids to fuel seedling establishment, one is via PCK1, and a second via PPDK.
Malate metabolism is important during dark-induced stomatal closure and that phosphoenolpyruvate carboxykinase (PEPCK) is involved in this process.
Study investigated the molecular basis of such effects focusing on a commonly studied polymorphism in pig Pgc1alpha, which changes a cysteine at position 430 (WT) of the protein to a serine (C430S); found that differential O-GlcNAcylation of Pgc1alpha regulates PCK1 activity and this molecular mechanism could explain at least in part the epistatic interaction between both genes.
Study identified a novel homozygous PCK1 missense mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia.
HBXIP (show HBXIP Antibodies) is able to depress the gluconeogenesis in hepatoma cells by suppressing PCK1 to promote hepatocarcinogenesis, involving miR (show MLXIP Antibodies)-135a/FOXO1 (show FOXO1 Antibodies) axis and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/p-FOXO1 (show FOXO1 Antibodies) pathway.
A mutation of PCK1 associated with Smith-Magenis Syndrome, cytosolic PEPCK (show PEPCK Antibodies) deficiency and NMDA receptor glutamate (show GRIN1 Antibodies) insensitivity.
Insulin (show INS Antibodies)-dependent translocation of FOXO1 (show FOXO1 Antibodies) regulated transcriptional repression of PCK1 concomitant with the formation of the FOXO1 (show FOXO1 Antibodies)-euchromatic histone-lysine N-methyltransferase2 (show DNMT1 Antibodies) (EHMT2 (show EHMT2 Antibodies)) complex and histone modifications of the PCK1 promoter region
Lipopolysaccharide and monophosphoryl lipid A also up-regulated G6PC (show G6PC Antibodies) and PCK1 transcript abundance in a TLR4 (show TLR4 Antibodies)-dependent manner.
The PCK1 tag-single nucleotide polymorphisms influenced insulin (show INS Antibodies) resistance by interacting with plasma n-3 polyunsaturated fatty acids levels in metabolic syndrome patients.
HCV core protein expression-mediated FOXO1 (show FOXO1 Antibodies) activation and the increased PGC-1alpha (show PPARGC1A Antibodies) leaded to the elevation of PCK1 at the mRNA level
Acetylation regulates the stability of the gluconeogenic rate-limiting enzyme PEPCK1.
Data show PEPCK-C and CPT-1 (show CPT1A Antibodies) mRNAs are more abundant in non-tumoral tissues than in the tumoral counterpart, whereas the opposite occurred for the FAS (show FAS Antibodies) gene.
the renal proximal tubule, may require the remodeling of AUF1 (show HNRNPD Antibodies) binding to the elements that mediate the rapid turnover of PEPCK (show PEPCK Antibodies) mRNA
Collectively, the identified 3'-untranslated-region SNP variant highlights the importance of PCK1 in the fecundity of Holstein bulls, and implicates a role for bta-miR (show MYLIP Antibodies)-26a in regulating PCK1 abundance.
Expression of cytosolic PEPCK (show PEPCK Antibodies) mRNA is transiently increased during early lactation, indicating that enhanced hepatic gluconeogenesis during lactation may be tied to enhanced capacity for cytosolic formation of phosphoenolpyruvate.
Data (including data from studies in knockout mice) suggest that Pck1 in liver plays role in glucose homeostasis; here, Pck1 deficiency (in knockout mice) can be successfully treated by re-expression of Pck1 in liver, thus partially rescuing pups from fatal neonatal hypoglycemia. Pck1 appears to play roles in metabolism in lung and skeletal muscle.
Silencing PCK1 or inhibiting its enzymatic activity slows the growth of tumor-repopulating cells in vitro and impedes tumorigenesis in vivo.
PEPCK-M expression partially rescued defects in lipid metabolism, gluconeogenesis and TCA cycle function impaired by PEPCK-C deletion, while approximately 10% re-expression of PEPCK-C normalized most parameters.
FAT/CD36 (show CD36 Antibodies) regulates PEPCK (show PEPCK Antibodies) in adipose tissue and that this could be secondary to reductions in lipolysis.
PCB (show PC Antibodies) 126 blunted the forskolin-stimulated increase in phosphoenolpyruvate carboxykinase (PEPCK (show PEPCK Antibodies)) mRNA levels.
the role of IL-6 (show IL6 Antibodies) signalling in adipose tissue during exercise
there are multiple cytokine pathways by which inflammation inhibits PEPCK (show PEPCK Antibodies) expression in adipose tissue which could contribute to the increased mobilization of fatty acids during inflammation
Glucagon (show GCG Antibodies) can also regulate Pck1 in the intestine, but not in the kidneys.
Pck1 plays an important role in both the mammary gland adipocytes and epithelial cells during lactation
Results suggest that HDAC3 (show HDAC3 Antibodies) mediates NF-kappaB (show NFKB1 Antibodies) activity to repress Pepck (show PEPCK Antibodies) transcription.
The regulatory properties of maize phosphoenolpyruvate carboxylase were significantly altered by site-directed mutagenesis of residues 226 through 232.
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.
, phosphoenol pyruvate carboxykinase
, phosphoenolpyruvate carboxy kinase
, phosphoenolpyruvate carboxykinase
, phosphoenolpyruvate carboxykinase, cytosolic
, phosphoenolpyruvate carboxykinase 1 (soluble)
, Phosphoenolpyruvate carboxykinase, cytosolic
, Phosphoenolpyruvate carboxykinase 1 (soluble)-like
, cytosolic phosphoenolpyruvate carboxykinase
, phosphoenolpyruvate carboxykinase, cytosolic [GTP]
, phosphoenolpyruvate carboxylase
, PEP carboxykinase
, phosphopyruvate carboxylase
, phosphoenolpyruvate carboxykinase 1 variant 1
, phosphoenolpyruvate carboxykinase 1 variant 2
, phosphoenolpyruvate carboxykinase 1 variant 3
, phosphoenolpyruvate carboxykinase 1 variant 4
, phosphoenolpyruvate carboxykinase 1 variant 5
, phosphoenolpyruvate carboxykinase (GTP)
, phosphoenolpyruvate carboxykinase 1, cytosolic
, phosphoenolpyruvate carboxykinase, cytosolic (GTP)
, gluconeogenic enzyme
, synonymous gene name: Pep2 in maize linkage map