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PCK1 antibody (C-Term)

PCK1 Reactivity: Human, Mouse, Rat WB, IHC (p), IF Host: Rabbit Polyclonal RB03646 unconjugated
Catalog No. ABIN1882180
  • Target See all PCK1 Antibodies
    PCK1 (phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1))
    Binding Specificity
    • 15
    • 9
    • 9
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 592-622, C-Term
    Reactivity
    • 77
    • 53
    • 28
    • 8
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 91
    • 9
    • 2
    • 2
    Rabbit
    Clonality
    • 88
    • 16
    Polyclonal
    Conjugate
    • 46
    • 10
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This PCK1 antibody is un-conjugated
    Application
    • 84
    • 43
    • 32
    • 18
    • 14
    • 12
    • 10
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PCK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-622 amino acids from the C-terminal region of human PCK1.
    Clone
    RB03646
    Isotype
    Ig Fraction
  • Application Notes
    IF: 1:10~50. WB: 1:1000. WB: 1:1000. WB: 1:2000. IHC-P-Leica: 1:250
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Gummadi, Taylor, Curthoys: "Concurrent binding and modifications of AUF1 and HuR mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells." in: American journal of physiology. Renal physiology, Vol. 303, Issue 11, pp. F1545-54, (2012) (PubMed).

    Berger, Lindh, Wierup, Zmuda-Trzebiatowska, Lindqvist, Manganiello, Degerman: "Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism." in: PLoS ONE, Vol. 4, Issue 3, pp. e4671, (2009) (PubMed).

    Franckhauser, Muñoz, Elias, Ferre, Bosch: "Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity." in: Diabetes, Vol. 55, Issue 2, pp. 273-80, (2006) (PubMed).

    Dunten, Belunis, Crowther, Hollfelder, Kammlott, Levin, Michel, Ramsey, Swain, Weber, Wertheimer: "Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site." in: Journal of molecular biology, Vol. 316, Issue 2, pp. 257-64, (2002) (PubMed).

    Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

    Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

    OBrien, Printz, Halmi, Tiesinga, Granner: "Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter." in: Biochimica et biophysica acta, Vol. 1264, Issue 3, pp. 284-8, (1996) (PubMed).

    Ting, Burgess, Chamberlain, Keith, Falls, Meisler: "Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20." in: Genomics, Vol. 16, Issue 3, pp. 698-706, (1993) (PubMed).

  • Target
    PCK1 (phosphoenolpyruvate Carboxykinase 1 (Soluble) (PCK1))
    Alternative Name
    PCK1 (PCK1 Products)
    Synonyms
    PEPCK-C antibody, PEPCK1 antibody, PEPCKC antibody, PEPCK antibody, PEPCK-M antibody, PEPCK2 antibody, 1810010O14Rik antibody, 9130022B02Rik antibody, cb856 antibody, cb924 antibody, fj93h11 antibody, zgc:63869 antibody, wu:fc51c05 antibody, wu:fj93h11 antibody, pepck-c antibody, pepck1 antibody, pepckc antibody, PCK1 antibody, PPCK1 antibody, AI265463 antibody, Pck-1 antibody, GTP antibody, PCK antibody, Pepck antibody, RATPEPCK antibody, Ppc1C antibody, PHOSPHOENOLPYRUVATE CARBOXYKINASE antibody, T28I19.150 antibody, T28I19_150 antibody, phosphoenolpyruvate carboxykinase 1 antibody, 143299_at antibody, CG10924 antibody, CG17725 antibody, Dmel\\CG17725 antibody, Dromel_CG17725_FBtr0086701_pepck_mORF antibody, dPEPCK antibody, pepck antibody, PEPC antibody, PEPCase antibody, ppc antibody, phosphoenolpyruvate carboxykinase 1 antibody, phosphoenolpyruvate carboxykinase 2, mitochondrial antibody, phosphoenolpyruvate carboxykinase 2 (mitochondrial) antibody, phosphoenolpyruvate carboxykinase 1 (soluble) antibody, phosphoenolpyruvate carboxykinase 1 S homeolog antibody, phosphoenolpyruvate carboxykinase, cytosolic [GTP] antibody, phosphoenolpyruvate carboxykinase 1, cytosolic antibody, phosphoenolpyruvate carboxylase 7 antibody, Phosphoenolpyruvate carboxykinase antibody, phosphoenolpyruvate carboxylase antibody, PCK1 antibody, PCK2 antibody, Pck2 antibody, pck1 antibody, pck1.S antibody, LOC100634531 antibody, Pck1 antibody, pep7 antibody, Pepck antibody, LOC107777405 antibody
    Background
    This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.
    Molecular Weight
    69195
    NCBI Accession
    NP_002582
    UniProt
    P35558
    Pathways
    Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis
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