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Browse our anti-PLK1 (PLK1) Antibodies

Full name:
anti-Polo-Like Kinase 1 Antibodies (PLK1)
On www.antibodies-online.com are 336 Polo-Like Kinase 1 (PLK1) Antibodies from 27 different suppliers available. Additionally we are shipping PLK1 Kits (12) and and many more products for this protein. A total of 377 PLK1 products are currently listed.
Synonyms:
0256/04, 1324/08, anon-WO0172774.3, cb525, cb636, CG12306, Dmel\CG12306, ik:tdsubc_2d1, l(3)01673, l(3)77Aa, l(3)S025604, l(3)S132408, Plk, PLK-1, PLK1, Plx1, Polo, POLO/PLK1, Polo kinase, Snk, STPK13, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1
list all antibodies Gene Name GeneID UniProt
PLK1 5347 P53350
PLK1 18817 Q07832
Anti-Rat PLK1 PLK1 25515 Q62673

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All available anti-PLK1 Antibodies

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Top referenced anti-PLK1 Antibodies

  1. Chicken Polyclonal PLK1 Primary Antibody for EIA, IHC (p) - ABIN117982 : van Vugt, Brás, Medema: Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. in Molecular cell 2004 (PubMed)
    Show all 6 references for ABIN117982

  2. Human Polyclonal PLK1 Primary Antibody for EIA, IHC (p) - ABIN4620390 : Ree, Bratland, Nome, Stokke, Fodstad: Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1. in Oncogene 2003 (PubMed)
    Show all 5 references for ABIN4620390

  3. Human Monoclonal PLK1 Primary Antibody for WB - ABIN967616 : Ando, Ozaki, Yamamoto, Furuya, Hosoda, Hayashi, Fukuzawa, Nakagawara: Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN967616

  4. Human Monoclonal PLK1 Primary Antibody for FACS, IHC - ABIN1098105 : Lin, Sun, Wang: Suppression of Polo like kinase 1 (PLK1) by p21(Waf1) mediates the p53-dependent prevention of caspase-independent mitotic death. in Cellular signalling 2011 (PubMed)
    Show all 3 references for ABIN1098105

  5. Human Monoclonal PLK1 Primary Antibody for ICC, ELISA - ABIN969580 : Lee, Rhee: PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis. in The Journal of cell biology 2011 (PubMed)
    Show all 2 references for ABIN969580

  6. Human Polyclonal PLK1 Primary Antibody for IHC (p), WB - ABIN392446 : Negishi, Kumano, Nishida: Polo-like kinase 1 is required for localization of Posterior End Mark protein to the centrosome-attracting body and unequal cleavages in ascidian embryos. in Development, growth & differentiation 2011 (PubMed)
    Show all 2 references for ABIN392446

  7. Cow (Bovine) Polyclonal PLK1 Primary Antibody for WB - ABIN372703 : van Vugt, van de Weerdt, Vader, Janssen, Calafat, Klompmaker, Wolthuis, Medema: Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. in The Journal of biological chemistry 2004 (PubMed)

  8. Human Polyclonal PLK1 Primary Antibody for IHC, ELISA - ABIN129581 : Adler, Müller, Rached, Dekant, Mally: Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. in Carcinogenesis 2009 (PubMed)

  9. Cow (Bovine) Polyclonal PLK1 Primary Antibody for IHC, WB - ABIN2782496 : Yamashiro, Yamakita, Totsukawa, Goto, Kaibuchi, Ito, Hartshorne, Matsumura: Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. in Developmental cell 2008 (PubMed)

More Antibodies against PLK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Polo-Like Kinase 1 (PLK1) interaction partners

  1. Cdk1 (show CDK1 Antibodies) phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles.

  2. Polo is an important in vivo regulator of the pathological functions of APP (show APP Antibodies).

  3. Both conditions impaired NSC lineage progression. Ca(2 (show CA2 Antibodies)) mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro

  4. During pericentriolar matrix formation exon 1A Cnn-Long Form proteins likely bind Polo kinase before phosphorylation by Polo for Cnn transport to the centrosome.

  5. Polo kinase is required for localization and activity of the chromosomal passenger complex in mitosis and meiosis.

  6. Centrioles, which usually separate during the anaphase of the first meiosis, remained held together in a V-shaped configuration suggesting that Polo kinase regulates the proteolysis that breaks centriole linkage to ensure their disengagement.

  7. Results show that Polo kinase positively and negatively regulates Augmin distribution for microtubule nucleation and acentrosomal spindle formation.

  8. Regulation of Polo by Aurora B (show AURKB Antibodies) and Map205 is required for cytokinesis.

  9. These data indicate APC (show APC Antibodies)(Cort (show CORT Antibodies)) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence.

  10. a model in which Polo controls Mps1-dependent BubR1 (show BUB1B Antibodies) phosphorylation to promote Cdc20 (show CDC20 Antibodies) kinetochore recruitment and sustained SAC (show ADCY10 Antibodies) function.

Xenopus laevis Polo-Like Kinase 1 (PLK1) interaction partners

  1. Novel roles for Plk and GSK3 (show GSK3b Antibodies) regulation of ADAM13 (show ADAM33 Antibodies) function in cranial neural crest cell migration.

  2. Plx1-mediated degradation of Bora in interphase generates oscillations in Plx1 activity and is essential for development.

  3. Coordinated interplays between Plx1 and Gwl (show MASTL Antibodies) are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

  4. the penultimate CRS (show CARS Antibodies) serine (Ser (show SIGLEC1 Antibodies) 101) of cyclin b1 (show CCNB1 Antibodies) is a Plx substrate

  5. Results suggest that polo-like kinase (Plx1) could be the missing regulator that prevents maturation-promoting factor autoamplification in stage IV oocytes.

  6. Plx1 cooperates with CaMKII (show CAMK2G Antibodies) to regulate cyclosome regulators, and is necessary for release of cytostatic factor metaphase arrest and sufficient when overexpressed.

  7. Data show that Plx1 couples tension signals to cellular responses through phosphorylation of the 3F3 (show TRIM32 Antibodies)/2 epitope and targeting structural and checkpoint proteins to kinetochores.

  8. Polo-like kinase Plx1 is an essential factor for calcium ion-induced meiotic exit during cytostatic factor arrest

  9. Polo-like kinase (Plx1) phosphorylates xTRF1 in vitro and the mitotic xTRF1-chromatin association was significantly impaired when Plx1 was immunodepleted from the extracts (Plx1).

  10. Cdk1 (show CDK1 Antibodies) phosphorylation of BubR1 (show BUB1B Antibodies) controls spindle checkpoint arrest and plk-mediated formation of the 3F3 (show TRIM32 Antibodies)/2 epitope.

Human Polo-Like Kinase 1 (PLK1) interaction partners

  1. Inhibition of PLK1 activity or overexpression of a non-phosphorylatable PLK1 mutant reduces the polyploid cell population.

  2. the mechanism of Plk1 activation and the potential role of Bora phosphorylation by Cdk1 (show CDK1 Antibodies), is reported.

  3. centrosome maturation occurs during interphase in an MLK (show MAP3K13 Antibodies)-dependent manner, independent of the classic mitotic kinase, Plk1.

  4. High PLK1 expression is associated with hepatocellular carcinoma.

  5. centrosome protein Dzip1 (show DZIP1 Antibodies) mediates the assembly of the BBSome-Dzip1 (show DZIP1 Antibodies)-PCM1 (show MBD1 Antibodies) complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 (show DZIP1 Antibodies) at Ser (show SIGLEC1 Antibodies)-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of Dzip1 (show DZIP1 Antibodies) and the BBSome from the CS.

  6. miR (show MLXIP Antibodies)-509-3-5p is a strong suppressor of cancer via targeting PLK1.

  7. These findings suggest that Plk1 regulates smooth muscle contraction by modulating vimentin (show VIM Antibodies) phosphorylation at Ser (show SIGLEC1 Antibodies)-56.

  8. we overexpressed CKS1B (show CKS1B Antibodies) in multiple cell lines and found increased sensitivity to PLK1 knockdown and PLK1 drug inhibition. Finally, combined inhibition of WEE1 (show WEE1 Antibodies) and PLK1 results in less apoptosis than predicted based on an additive model of the individual inhibitors, showing an epistatic interaction and confirming a prediction of the yeast data.

  9. Mechanistically, the phosphorylation of Sds22 (show PPP1R7 Antibodies) by PLK1 strengthens the binding of Sds22 (show PPP1R7 Antibodies) to PP1 (show PPA1 Antibodies) and inhibits the dephosphorylation of Thr (show TRH Antibodies)(232) of Aurora B (show AURKB Antibodies) to ensure a robust, error-free metaphase-anaphase transition.

  10. The Plk1 at the kinetochore is a conglomerate of an observable bulk pool coupled with additional functional pools below the threshold of microscopic detection or resolution.

Pig (Porcine) Polo-Like Kinase 1 (PLK1) interaction partners

  1. Thus, these results indicated that Plk1 is essential for porcine embryos to complete the first mitotic division. Furthermore, Plk1 regulation was associated with effects on spindle assembly and chromosome arrangement

  2. PLK1 might play a critical role in vascular smooth muscle cell mitosis in hyperplastic intima of the injured vessels.

  3. Data show that Polo-like kinase 1 is activated before M phase promoting factor (MPF (show MSLN Antibodies)), which is consistent with its role in activating MPF (show MSLN Antibodies) in mammalian oocytes.

Mouse (Murine) Polo-Like Kinase 1 (PLK1) interaction partners

  1. centrosome maturation occurs during interphase in an MLK (show MUSK Antibodies)-dependent manner, independent of the classic mitotic kinase, Plk1.

  2. centrosome protein Dzip1 (show DZIP1 Antibodies) mediates the assembly of the BBSome-Dzip1 (show DZIP1 Antibodies)-PCM1 (show MBD1 Antibodies) complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 (show DZIP1 Antibodies) at Ser (show SIGLEC1 Antibodies)-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of Dzip1 (show DZIP1 Antibodies) and the BBSome from the CS.

  3. These findings suggest that Plk1 regulates smooth muscle contraction by modulating vimentin (show VIM Antibodies) phosphorylation at Ser (show SIGLEC1 Antibodies)-56.

  4. Results indicate that polo-like kinase 1 (PLK1) controls the onset of spindle assembly and spindle formation, and is essential for anaphase-promoting complex/cyclosome (APC (show APC Antibodies)/C) activation before anaphase onset in zygotes.

  5. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  6. Plk1 activity is required for meiotic spindle assembly and REC8 (show REC8 Antibodies) cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division.

  7. Augmented expression of Aurora kinase-A (show AURKA Antibodies) and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells.

  8. Combined Plk1-HDAC (show HDAC3 Antibodies) inhibition reduces survival in Hela cells but not in non-cancer cells.

  9. PLK1 is required for the full activation of the anaphase promoting complex/cyclosome, for proper chromosome segregation and the maintenance of chromosome condensation during the meiosis I-II transition.

  10. we show here that Polo-like kinase 1 (Plk1) is required for endomitosis, and ablation of the Plk1 gene in megakaryocytes results in defective polyploidization accompanied by mitotic arrest and cell death

Zebrafish Polo-Like Kinase 1 (PLK1) interaction partners

  1. Report the 2.3-A crystal structure of the complex of the N-terminal kinase domain (KD) and a C-terminal Polo-box domain (PBD together with a PBD-binding motif of Drosophila melanogaster microtubule-associated protein (show FAM82A2 Antibodies) 205 (Map205(PBM)).

  2. Studies demonstrate that Plk1 is required for embryonic proliferation because its activity is crucial for mitotic integrity.

  3. for the first time that Plk1 can accommodate extended ATP-competitive compounds that project toward the adaptive pocket and help the enzyme order its activation segment

Caenorhabditis elegans (C. elegans) Polo-Like Kinase 1 (PLK1) interaction partners

  1. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.

  2. Our data further show that PLK-1 is needed for nuclear envelope breakdown during early embryogenesis

  3. PLK-1 substitutes for Mps1 in controlling spindle checkpoint initiation in C. elegans.

  4. NCAPG2 (show NCAPG2 Antibodies) plays an important role in regulating proper chromosome segregation through a functional interaction with PLK1 during mitosis

  5. CDK-1 (show CDK1 Antibodies) activates PLK-1 via SPAT (show AGXT Antibodies)-1 phosphorylation to promote entry into mitosis.

  6. The result provide key insights into the regulation of homolog pairing and reveal that targeting of plk-1 to the NE by meiotic chromosomes establishes the conserved linkages to cytoskeletal forces needed for homology assessment.

  7. SPAT (show AGXT Antibodies)-1 and PLK-1 depletion causes impaired polarity with abnormal length of the anterior and posterior PAR (show AFG3L2 Antibodies) domains, and partial plk-1(RNAi) or spat (show AGXT Antibodies)-1(RNAi), but not air-1(RNAi), can rescue the lethality of a par-2 (show F2RL1 Antibodies) mutant.

  8. Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX (show ZSWIM2 Antibodies)-6.

  9. plk-1 asymmetry contributes to asynchronous cell division in C. elegans embryos.

  10. We suggest that control of Plk1 and Cdc25 (show CDC25C Antibodies) may be relevant to regulation of cell cycle length in other developmental contexts.

PLK1 Antigen Profile

Antigen Summary

human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis

Alternative names and synonyms associated with PLK1

  • polo-like kinase 1 (plk1) antibody
  • CG12306 gene product from transcript CG12306-RA (polo) antibody
  • polo-like kinase 1 (PLK1) antibody
  • polo-like kinase 1 (Plk1) antibody
  • polo-like kinase 1 (Drosophila) (plk1) antibody
  • polo-like kinase 2 (Plk2) antibody
  • Protein PLK-1 (plk-1) antibody
  • 0256/04 antibody
  • 1324/08 antibody
  • anon-WO0172774.3 antibody
  • cb525 antibody
  • cb636 antibody
  • CG12306 antibody
  • Dmel\CG12306 antibody
  • ik:tdsubc_2d1 antibody
  • l(3)01673 antibody
  • l(3)77Aa antibody
  • l(3)S025604 antibody
  • l(3)S132408 antibody
  • Plk antibody
  • PLK-1 antibody
  • PLK1 antibody
  • Plx1 antibody
  • Polo antibody
  • POLO/PLK1 antibody
  • Polo kinase antibody
  • Snk antibody
  • STPK13 antibody
  • wu:fb37g11 antibody
  • wu:fb76g03 antibody
  • xx:tdsubc_2d1 antibody

Protein level used designations for PLK1

serine/threonine-protein kinase PLK1 , CG12306-PA , CG12306-PB , polo kinase , polo protein kinase , polo-PA , polo-PB , PLK-1 , plx1 , cell cycle regulated protein kinase , polo (Drosophia)-like kinase , polo like kinase , serine/threonine-protein kinase 13 , polo-like protein kinase , polo-like kinase homolog , PLK-2 , polo-like kinase 1 , serine/threonine-protein kinase PLK2 , serine/threonine-protein kinase SNK , serum-inducible kinase

GENE ID SPECIES
407937 Xenopus (Silurana) tropicalis
40232 Drosophila melanogaster
380481 Xenopus laevis
416575 Gallus gallus
453991 Pan troglodytes
5347 Homo sapiens
489971 Canis lupus familiaris
396953 Sus scrofa
18817 Mus musculus
25515 Rattus norvegicus
538238 Bos taurus
280649 Danio rerio
83722 Rattus norvegicus
176143 Caenorhabditis elegans
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