Browse our anti-PLK1 (PLK1) Antibodies

Full name:
anti-Polo-Like Kinase 1 Antibodies (PLK1)
On are 376 Polo-Like Kinase 1 (PLK1) Antibodies from 27 different suppliers available. Additionally we are shipping PLK1 Kits (14) and and many more products for this protein. A total of 424 PLK1 products are currently listed.
0256/04, 1324/08, anon-WO0172774.3, cb525, cb636, CG12306, Dmel\CG12306, ik:tdsubc_2d1, l(3)01673, l(3)77Aa, l(3)S025604, l(3)S132408, Plk, PLK-1, PLK1, Plx1, Polo, POLO/PLK1, Polo kinase, Snk, STPK13, wu:fb37g11, wu:fb76g03, xx:tdsubc_2d1
list all antibodies Gene Name GeneID UniProt
PLK1 5347 P53350
PLK1 18817 Q07832
Anti-Rat PLK1 PLK1 25515 Q62673

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Top referenced anti-PLK1 Antibodies

  1. Human Monoclonal PLK1 Primary Antibody for FACS, IHC - ABIN1098105 : Lin, Sun, Wang: Suppression of Polo like kinase 1 (PLK1) by p21(Waf1) mediates the p53-dependent prevention of caspase-independent mitotic death. in Cellular signalling 2011 (PubMed)
    Show all 3 references for 1098105

  2. Human Monoclonal PLK1 Primary Antibody for WB - ABIN967616 : Ando, Ozaki, Yamamoto, Furuya, Hosoda, Hayashi, Fukuzawa, Nakagawara: Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for 967616

  3. Human Monoclonal PLK1 Primary Antibody for ICC, ELISA - ABIN969580 : Lee, Rhee: PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis. in The Journal of cell biology 2011 (PubMed)
    Show all 2 references for 969580

  4. Human Polyclonal PLK1 Primary Antibody for IHC (p), WB - ABIN392446 : Negishi, Kumano, Nishida: Polo-like kinase 1 is required for localization of Posterior End Mark protein to the centrosome-attracting body and unequal cleavages in ascidian embryos. in Development, growth & differentiation 2011 (PubMed)
    Show all 2 references for 392446

  5. Human Monoclonal PLK1 Primary Antibody for ICS - ABIN1177152 : Jang, Ma, Terada, Erikson: Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. in The Journal of biological chemistry 2002 (PubMed)

  6. Human Monoclonal PLK1 Primary Antibody for ICS - ABIN1177154 : Peter, Gleixner, Cerny-Reiterer, Herrmann, Winter, Hadzijusufovic, Ferenc, Schuch, Mirkina, Horny, Pickl, Müllauer, Willmann, Valent: Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536. in Haematologica 2011 (PubMed)

  7. Human Polyclonal PLK1 Primary Antibody for IHC, ELISA - ABIN129581 : Adler, Müller, Rached, Dekant, Mally: Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. in Carcinogenesis 2009 (PubMed)

  8. Cow (Bovine) Polyclonal PLK1 Primary Antibody for IHC, WB - ABIN2782496 : Yamashiro, Yamakita, Totsukawa, Goto, Kaibuchi, Ito, Hartshorne, Matsumura: Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. in Developmental cell 2008 (PubMed)

More Antibodies against PLK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Polo-Like Kinase 1 (PLK1) interaction partners

  1. Study shows that cnn exon1A-encoded proteins interact with Polo at 2 residues and that this interaction is required for polar body and pericentriolar matrix formation in syncytial embryos.

  2. Cdk1 (show CDK1 Antibodies) phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles.

  3. Polo is an important in vivo regulator of the pathological functions of APP (show APP Antibodies).

  4. Both conditions impaired NSC lineage progression. Ca(2 (show CA2 Antibodies)) mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro

  5. During pericentriolar matrix formation exon 1A Cnn-Long Form proteins likely bind Polo kinase before phosphorylation by Polo for Cnn transport to the centrosome.

  6. Polo kinase is required for localization and activity of the chromosomal passenger complex in mitosis and meiosis.

  7. Centrioles, which usually separate during the anaphase of the first meiosis, remained held together in a V-shaped configuration suggesting that Polo kinase regulates the proteolysis that breaks centriole linkage to ensure their disengagement.

  8. Results show that Polo kinase positively and negatively regulates Augmin distribution for microtubule nucleation and acentrosomal spindle formation.

  9. Regulation of Polo by Aurora B (show AURKB Antibodies) and Map205 is required for cytokinesis.

  10. These data indicate APC (show APC Antibodies)(Cort (show CORT Antibodies)) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence.

Xenopus laevis Polo-Like Kinase 1 (PLK1) interaction partners

  1. Novel roles for Plk and GSK3 (show GSK3b Antibodies) regulation of ADAM13 (show ADAM33 Antibodies) function in cranial neural crest cell migration.

  2. Plx1-mediated degradation of Bora in interphase generates oscillations in Plx1 activity and is essential for development.

  3. Coordinated interplays between Plx1 and Gwl (show MASTL Antibodies) are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

  4. the penultimate CRS (show CARS Antibodies) serine (Ser (show SIGLEC1 Antibodies) 101) of cyclin b1 (show CCNB1 Antibodies) is a Plx substrate

  5. Results suggest that polo-like kinase (Plx1) could be the missing regulator that prevents maturation-promoting factor autoamplification in stage IV oocytes.

  6. Plx1 cooperates with CaMKII (show CAMK2G Antibodies) to regulate cyclosome regulators, and is necessary for release of cytostatic factor metaphase arrest and sufficient when overexpressed.

  7. Data show that Plx1 couples tension signals to cellular responses through phosphorylation of the 3F3 (show TRIM32 Antibodies)/2 epitope and targeting structural and checkpoint proteins to kinetochores.

  8. Polo-like kinase Plx1 is an essential factor for calcium ion-induced meiotic exit during cytostatic factor arrest

  9. Polo-like kinase (Plx1) phosphorylates xTRF1 in vitro and the mitotic xTRF1-chromatin association was significantly impaired when Plx1 was immunodepleted from the extracts (Plx1).

  10. Cdk1 (show CDK1 Antibodies) phosphorylation of BubR1 (show BUB1B Antibodies) controls spindle checkpoint arrest and plk-mediated formation of the 3F3 (show TRIM32 Antibodies)/2 epitope.

Human Polo-Like Kinase 1 (PLK1) interaction partners

  1. Mutant IDH1 (show IDH1 Antibodies) promotes checkpoint adaptation which can be exploited therapeutically with the combination of TMZ and a PLK1 inhibitor, indicating PLK1 inhibitors may be clinically valuable in the treatment of IDH1 (show IDH1 Antibodies) mutant gliomas

  2. Genistein induced mitotic arrest by inhibiting Plk1 activity and, consequently, led to mitotic catastrophe and apoptosis. Tumor cells with TP53 (show TP53 Antibodies) mutations were more sensitive to cell death by treatment of genistein.

  3. we show that Plk1 phosphorylates Mre11 (show MRE11A Antibodies) at S649 during G2 DNA damage recovery and Mre11 (show MRE11A Antibodies) phosphorylation at S649/S689 drives premature checkpoint termination and reduced DNA repair

  4. We propose that the DDR (show DDR1 Antibodies) targets recruitment of Aurora A (show AURKA Antibodies) to the Plk1/Bora complex to prevent activation of Plk1 during DNA damage in G2.

  5. The findings reveal a PLK1-Fbw7 (show FBXW7 Antibodies)-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.

  6. Studies provide evidence that PLK1 plays a role during cell cycle progression and human pediatric cancer. [review]

  7. Small molecule inhibition of polo-like kinase 1 by volasertib (BI 6727) causes significant melanoma growth delay and regression in vivo.

  8. Mutations of the LIM protein (show CSRP1 Antibodies) AJUBA (show AJUBA Antibodies) mediate sensitivity of head and neck squamous cell carcinomas to treatment with PLK1 inhibitors.

  9. PLK1 may be an important regulator of metabolism maintenance in melanoma cells.

  10. The authors show that a global spread of ATM (show ATM Antibodies) activity on chromatin and phosphorylation of ATM (show ATM Antibodies) targets including KAP1 (show CDKN3 Antibodies) control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1 (show PPM1D Antibodies), allowing cell cycle restart despite persistent ATM (show ATM Antibodies) activity present at DNA lesions.

Pig (Porcine) Polo-Like Kinase 1 (PLK1) interaction partners

  1. Thus, these results indicated that Plk1 is essential for porcine embryos to complete the first mitotic division. Furthermore, Plk1 regulation was associated with effects on spindle assembly and chromosome arrangement

  2. PLK1 might play a critical role in vascular smooth muscle cell mitosis in hyperplastic intima of the injured vessels.

  3. Data show that Polo-like kinase 1 is activated before M phase promoting factor (MPF (show MSLN Antibodies)), which is consistent with its role in activating MPF (show MSLN Antibodies) in mammalian oocytes.

Mouse (Murine) Polo-Like Kinase 1 (PLK1) interaction partners

  1. Plk1 regulated angiotensin II-dependent activation of RhoA (show RHOA Antibodies) and actomyosin dynamics in VSMCs in a mitosis-independent manner. This regulation depended on Plk1 kinase activity. Plk1 haploinsufficiency in mice did not induce obvious cell proliferation defects but did result in arterial structural alterations, which frequently led to aortic rupture and death.

  2. The findings reveal a PLK1-Fbw7 (show FBXW7 Antibodies)-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.

  3. These data implicate the insulin (show INS Antibodies)-FoxM1 (show FOXM1 Antibodies)/PLK1/CENP-A (show CENPA Antibodies) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  4. centrosome maturation occurs during interphase in an MLK (show MUSK Antibodies)-dependent manner, independent of the classic mitotic kinase, Plk1.

  5. centrosome protein Dzip1 (show DZIP1 Antibodies) mediates the assembly of the BBSome-Dzip1 (show DZIP1 Antibodies)-PCM1 (show MBD1 Antibodies) complex in the centriolar satellites (CS) at the G0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 (show DZIP1 Antibodies) at Ser (show SIGLEC1 Antibodies)-210 by Plk1 (polo-like kinase 1) during the G2 phase promotes disassembly of this complex, resulting in removal of Dzip1 (show DZIP1 Antibodies) and the BBSome from the CS.

  6. These findings suggest that Plk1 regulates smooth muscle contraction by modulating vimentin (show VIM Antibodies) phosphorylation at Ser (show SIGLEC1 Antibodies)-56.

  7. Results indicate that polo-like kinase 1 (PLK1) controls the onset of spindle assembly and spindle formation, and is essential for anaphase-promoting complex/cyclosome (APC (show APC Antibodies)/C) activation before anaphase onset in zygotes.

  8. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  9. Plk1 activity is required for meiotic spindle assembly and REC8 (show REC8 Antibodies) cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division.

  10. Augmented expression of Aurora kinase-A (show AURKA Antibodies) and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells.

Zebrafish Polo-Like Kinase 1 (PLK1) interaction partners

  1. Report the 2.3-A crystal structure of the complex of the N-terminal kinase domain (KD) and a C-terminal Polo-box domain (PBD together with a PBD-binding motif of Drosophila melanogaster microtubule-associated protein (show FAM82A2 Antibodies) 205 (Map205(PBM)).

  2. Studies demonstrate that Plk1 is required for embryonic proliferation because its activity is crucial for mitotic integrity.

  3. for the first time that Plk1 can accommodate extended ATP-competitive compounds that project toward the adaptive pocket and help the enzyme order its activation segment

Caenorhabditis elegans (C. elegans) Polo-Like Kinase 1 (PLK1) interaction partners

  1. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.

  2. Our data further show that PLK-1 is needed for nuclear envelope breakdown during early embryogenesis

  3. PLK-1 substitutes for Mps1 in controlling spindle checkpoint initiation in C. elegans.

  4. NCAPG2 (show NCAPG2 Antibodies) plays an important role in regulating proper chromosome segregation through a functional interaction with PLK1 during mitosis

  5. CDK-1 (show CDK1 Antibodies) activates PLK-1 via SPAT (show AGXT Antibodies)-1 phosphorylation to promote entry into mitosis.

  6. The result provide key insights into the regulation of homolog pairing and reveal that targeting of plk-1 to the NE by meiotic chromosomes establishes the conserved linkages to cytoskeletal forces needed for homology assessment.

  7. SPAT (show AGXT Antibodies)-1 and PLK-1 depletion causes impaired polarity with abnormal length of the anterior and posterior PAR (show AFG3L2 Antibodies) domains, and partial plk-1(RNAi) or spat (show AGXT Antibodies)-1(RNAi), but not air-1(RNAi), can rescue the lethality of a par-2 (show F2RL1 Antibodies) mutant.

  8. Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX (show ZSWIM2 Antibodies)-6.

  9. plk-1 asymmetry contributes to asynchronous cell division in C. elegans embryos.

  10. We suggest that control of Plk1 and Cdc25 (show CDC25C Antibodies) may be relevant to regulation of cell cycle length in other developmental contexts.

PLK1 Antigen Profile

Antigen Summary

human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis

Alternative names and synonyms associated with PLK1

  • polo-like kinase 1 (plk1) antibody
  • CG12306 gene product from transcript CG12306-RA (polo) antibody
  • polo-like kinase 1 (PLK1) antibody
  • polo-like kinase 1 (Plk1) antibody
  • polo-like kinase 1 (Drosophila) (plk1) antibody
  • polo-like kinase 2 (Plk2) antibody
  • Protein PLK-1 (plk-1) antibody
  • 0256/04 antibody
  • 1324/08 antibody
  • anon-WO0172774.3 antibody
  • cb525 antibody
  • cb636 antibody
  • CG12306 antibody
  • Dmel\CG12306 antibody
  • ik:tdsubc_2d1 antibody
  • l(3)01673 antibody
  • l(3)77Aa antibody
  • l(3)S025604 antibody
  • l(3)S132408 antibody
  • Plk antibody
  • PLK-1 antibody
  • PLK1 antibody
  • Plx1 antibody
  • Polo antibody
  • POLO/PLK1 antibody
  • Polo kinase antibody
  • Snk antibody
  • STPK13 antibody
  • wu:fb37g11 antibody
  • wu:fb76g03 antibody
  • xx:tdsubc_2d1 antibody

Protein level used designations for PLK1

serine/threonine-protein kinase PLK1 , CG12306-PA , CG12306-PB , polo kinase , polo protein kinase , polo-PA , polo-PB , PLK-1 , plx1 , cell cycle regulated protein kinase , polo (Drosophia)-like kinase , polo like kinase , serine/threonine-protein kinase 13 , polo-like protein kinase , polo-like kinase homolog , PLK-2 , polo-like kinase 1 , serine/threonine-protein kinase PLK2 , serine/threonine-protein kinase SNK , serum-inducible kinase

407937 Xenopus (Silurana) tropicalis
40232 Drosophila melanogaster
380481 Xenopus laevis
416575 Gallus gallus
453991 Pan troglodytes
5347 Homo sapiens
489971 Canis lupus familiaris
396953 Sus scrofa
18817 Mus musculus
25515 Rattus norvegicus
538238 Bos taurus
280649 Danio rerio
83722 Rattus norvegicus
176143 Caenorhabditis elegans
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