(Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B))
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Aoyama, Hashii, Tsukimura, Osumi, Harazono, Tada, Kiyoshi, Matsuda, Ishii-Watabe: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).
Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: "Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9986-93, (2009) (PubMed).
Aliases for FCGR2B Proteins
Fc fragment of IgG receptor IIb (FCGR2B) Proteins Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B) Proteins Fc receptor, IgG, low affinity IIb (Fcgr2b) Proteins Fc fragment of IgG receptor IIb (Fcgr2b) Proteins low affinity immunoglobulin gamma Fc region receptor II (LOC100856270) Proteins AI528646 Proteins CD32 Proteins CD32B Proteins F630109E10Rik Proteins FCG2 Proteins FCGR2 Proteins Fcgr2 Proteins Fcgr2a Proteins FCGR2B Proteins FcgRII Proteins Fcr-2 Proteins Fcr-3 Proteins FCRII Proteins FcRII Proteins Fc[g]RII Proteins IGFR2 Proteins Ly-17 Proteins Ly-m20 Proteins LyM-1 Proteins Lym-1 Proteins