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Human IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN413464
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
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study found that IL-18 and IL-1beta (show IL1B Proteins) are differentially regulated. Despite being constitutively expressed, IL-18 expression was increased and sustained after stimulation of TLRs. In contrast, IL-1beta (show IL1B Proteins) was induced but not sustained after chronic treatment.
the GLA (show GLA Proteins)-SE adjuvant operates through interaction with IL-18-producing SCMsmall ef, Cyrillic for the rapid induction of B cell expansion and differentiation, Ab secretion, and Th1 (show HAND1 Proteins) responses
IL-18 is essentially involved in mediating C. jejuni infection in the gnotobiotic mouse model.
These results demonstrate a central role for the AIM2 (show AIM2 Proteins) inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18/IL-22BP (show IL22RA2 Proteins)/IL-22 (show IL22 Proteins) and STAT3 (show STAT3 Proteins) pathway
Aldosterone induced IL-18 gene expression in renal tubular epithelial cells in a concentration- and time-dependent manner.
this study demonstrated the critical function of IL-18 in lipid metabolism and these findings might contribute to the progress of novel treatments for nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.
Results indicated that IL-18 has roles apart from those as a proinflammatory cytokine in cardiac myocytes and suggested that IL-18 contributes to the homeostatic maintenance of mitochondrial function and gap-junction turnover in cardiac myocytes, possibly by upregulating autophagy.
IL-18-elicited NK cell perforin (show PRF1 Proteins) responses seem to be critical for coordinating mucosal inflammation during early infection
Data indicate that NLRC4 (show NLRC4 Proteins) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 release, and implicate Caspase-8 (show CASP8 Proteins) in NLRC4 (show NLRC4 Proteins) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (show CASP1 Proteins) and Caspase-8 (show CASP8 Proteins).
this study shows that IL-18, cooperatively with IL-23 (show IL23A Proteins), induced prominent inflammation and enhanced psoriasis-like epidermal hyperplasia
Study reports that the monocyte-derived cytokines IL-12 (show IL12A Proteins) and IL-18 act synergistically on porcine gammadelta T cells to induce IFN-gamma (show IFNG Proteins) production. Additional stimuli such as the mitogen ConA and IL-2 (show IL2 Proteins) are necessary to activate the cells for enhanced proliferation.
IL-18 concentration in saliva (show RAG1AP1 Proteins) was significantly increased during a 60-min acute immobilization stress in thirteen 5-month-old pigs. These results are the first evidence of a stress-related change of IL-18 in pig saliva (show RAG1AP1 Proteins).
endometrial expression of CASP1 (show CASP1 Proteins) and IL18 associated with pregnancy establishment; alteration of CASP1 (show CASP1 Proteins) and IL18 following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
Porcine IL-18 regulates anti-pig cellular rejection in C57BL/6 mice.
We conclude that IL-18 protein and messenger RNA levels are increased in the endometrium of patients with PCOS, and this effect is correlated with body mass index.
Serum IL-18 levels are significantly elevated in depressive patients.
IL-18 cooperates with IL-15 (show IL15 Proteins) to promote group 3 innate lymphoid cell (ILC3) proliferation and IL-22 (show IL22 Proteins) production; describe an IL-18-induced, NF-kappaB (show NFKB1 Proteins)-mediated mechanism that regulates IL-22 (show IL22 Proteins) in ILC3s; at steady-state, IL-18 produced by dendritic cells mediates IL-22 (show IL22 Proteins) production by ILC3s to help maintain normal tissue integrity
The low expression of HDAC3 (show HDAC3 Proteins) and overexpession of inflammatory cytokines (IL-18, IL-12 (show IL12A Proteins) and TNF-alpha (show TNF Proteins)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
IL-18 alleles, -656T (rs1946519) and -607A (rs1946518), are associated with dust mite-sensitive allergic rhinitis in Thai population.
IL-18 SNPs were associated with pulmonary tuberculosis with co-morbid diabetes in patients and their household contacts.
this study shows il-18 restores the phosphoantigen response of Vgamma9Vdelta2+ T cells from HIV-positive individuals on antiretroviral therapy
IL-18, IL-18R and IL-18BP (show IL18BP Proteins) expression in eosinophil are involved in the inflammatory reaction of asthma.
Patients with NLRP1-associated autoinflammation with arthritis and dyskeratosis syndrome had increased systemic IL18.
Genetic polymorphisms within the FUCA2 (show FUCA2 Proteins) and IL18 gene regions are also associated with diastolic function in SCD (show SCD Proteins), likely by affecting expression levels of the genes
These results suggest that BAPC-1 is a stem/progenitor cell line and modulates the immuno-endocrine function of the anterior pituitary cells through its production of interleukin-18 and the IL-18 receptor.
Pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP (show IL18BP Proteins).
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, IL-1 gamma
, interferon gamma-inducing factor
, interferon-gamma-inducing factor
, interleukin-1 gamma
, interferon gamma inducing factor
, Interferon gamma-inducing factor
, interleukin 18
, uncharacterized protein LOC100734451