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IL-18 Protein (His tag)

IL18 Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7318654
  • Target See all IL-18 (IL18) Proteins
    IL-18 (IL18) (Interleukin 18 (IL18))
    Protein Type
    Recombinant
    Origin
    • 19
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 30
    • 9
    • 3
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This IL-18 protein is labelled with His tag.
    Purpose
    Recombinant Human Interleukin-18/IL-18 Protein (His Tag)
    Sequence
    Tyr37-Asp193
    Characteristics
    Recombinant Human Interleukin-18 is produced by our Mammalian expression system and the target gene encoding Tyr37-Asp193 is expressed with a 6His tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin Level
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product IL18 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    IL-18 (IL18) (Interleukin 18 (IL18))
    Alternative Name
    Interleukin-18/IL-18 (IL18 Products)
    Synonyms
    Igif Protein, Il-18 Protein, IL-18 Protein, IGIF Protein, ChIL-18 Protein, IL-1g Protein, IL1F4 Protein, IL18 Protein, interleukin 18 Protein, Il18 Protein, IL18 Protein
    Background

    Background: Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.

    Synonym: Interleukin-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma,GIF, IL-18, IL-1g, IL1F4, MGC12320

    Molecular Weight
    23.3 kDa
    UniProt
    Q14116
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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