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this paper shows that IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium
Low IL24 expression is associated with endometriosis.
IL-20 (show IL20 Proteins) and IL-24 increased the production of monocyte chemoattractant protein-1 (show CCL2 Proteins) by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 (show DKK1 Proteins) by SpA (show FASL Proteins) fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 (show IL20 Proteins) and IL-24 in spondyloarthritis
we aimed to investigate the associations between the 7383A/G and 7488A/G polymorphisms of the interleukin (IL)-17F (show IL17F Proteins) gene with disease activity and clinical outcomes in Turkish patients with ankylosing spondylitis
Using an in-vitro migration assay, B cells were shown to migrate towards both IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins). These observations indicate a direct chemotactic effect of IL-17 (show IL17A Proteins) cytokines on primary peripheral blood B cells with higher effect being on asthmatic B cells.
IL-17 (show IL17A Proteins)-related cytokines expression was amplified in bronchial/nasal mucosa of neutrophilic asthma prone to exacerbation, suggesting a pathogenic role of IL-17F (show IL17F Proteins) in frequent exacerbators.
a novel pathway for mda-7/IL-24-induced caspase (show CASP3 Proteins)-independent apoptosis in neuroblastoma (show ARHGEF16 Proteins) cells mediated through modulation of AIF (show AIFM1 Proteins), ATM (show ATM Proteins), and gamma-H2AX (show H2AFX Proteins).
mda-7/IL-24 directly regulates miRNA expression in cancer cells and highlights the novelty of the mda-7/IL-24-miR (show MLXIP Proteins)-221-beclin-1 (show BECN1 Proteins) loop in mediating cancer cell-specific death.
IL-17A (-197G/A) and IL-17F (7488T/C) SNPs were not associated with susceptibility to rheumatoid arthritis or secondary Sjogrens syndrome (sSS, p > 0.05 for both SNPs). In addition, they did not influence RA activity or clinical markers of SS.
It can be stated that the IL17A (show IL17A Proteins) and IL17F (show IL17F Proteins) polymorphisms are not markers of susceptibility to psoriasis. However, the IL17F (show IL17F Proteins) polymorphism may affect the response to NB-UVB therapy.
our data suggest that IL-20 (show IL20 Proteins) subfamily cytokines, particularly IL-20 (show IL20 Proteins), IL-22 (show IL22 Proteins), and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
this study shows that IL-24 promotes Pseudomonas aeruginosa keratitis through the suppression of early protective mucosal immunity
Loss of IL-24 expression is associated with breast cancer.
A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB (show NFKB1 Proteins) was triggered by TNFR1 (show TNFRSF1A Proteins)-dependent upregulation of interleukin-24 & activation of STAT3 (show STAT3 Proteins) signaling in keratinocytes.
IL-24 suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS (show ROS1 Proteins)) production through the regulation of mitochondrial ROS (show ROS1 Proteins) production and expression of antioxidant enzymes
Secretory mIL-24 did not induce the expression of the IL-6 (show IL6 Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) gene in spleen cells
T cell receptor stimulation induces IL-24 expression in T helper type (Th)2 cells by the coordinate action of Stat6 (show STAT6 Proteins) and c-Jun (show JUN Proteins) transcription factors at the transcriptional level.
induction of Il24 by oncogenes may support tumor growth at the early stages of cancer
Grp170 (show HYOU1 Proteins) enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, cytokine ML-1
, mutant IL-17F
, IL-4-induced secreted protein
, melanocyte-associated Mda-7
, melanoma differentiation-associated gene 7 protein
, suppression of tumorigenicity 16 (melanoma differentiation)
, cytokine-like protein Mob-5
, th2-specific cytokine FISP