Browse our anti-Polymerase (DNA Directed) iota (POLI) Antibodies

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anti-Polymerase (DNA Directed) iota Antibodies (POLI)
On are 95 Polymerase (DNA Directed) iota (POLI) Antibodies from 16 different suppliers available. Additionally we are shipping Polymerase (DNA Directed) iota Proteins (5) and many more products for this protein. A total of 103 Polymerase (DNA Directed) iota products are currently listed.
GB12093, NV16187, poli, RAD3OB, Rad30b, wu:fc27h11, zgc:110185
list all antibodies Gene Name GeneID UniProt
POLI 11201 Q9UNA4
POLI 26447 Q6R3M4
POLI 291526  

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Most Popular Reactivities for anti-Polymerase (DNA Directed) iota (POLI) Antibodies

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Top referenced anti-Polymerase (DNA Directed) iota Antibodies

  1. Human Polyclonal POLI Primary Antibody for ICC, IF - ABIN151275 : Choi, Besaratinia, Lee, Lee, Pfeifer: The role of DNA polymerase iota in UV mutational spectra. in Mutation research 2006 (PubMed)
    Show all 3 references for 151275

  2. Human Monoclonal POLI Primary Antibody for ELISA, WB - ABIN564869 : Wang, Woodgate, McManus, Mead, McCormick, Maher: Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations. in Cancer research 2007 (PubMed)
    Show all 3 references for 564869

  3. Human Polyclonal POLI Primary Antibody for ELISA, WB - ABIN1534839 : McDonald, Rapić-Otrin, Epstein, Broughton, Wang, Lehmann, Wolgemuth, Woodgate: Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta. in Genomics 1999 (PubMed)

  4. Human Polyclonal POLI Primary Antibody for IP, WB - ABIN253139 : Ziv, Zeisel, Mirlas-Neisberg, Swain, Nevo, Ben-Chetrit, Martelli, Rossi, Schiesser, Canman, Carell, Geacintov, Falini, Domany, Livneh: Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin. in Nature communications 2014 (PubMed)

More Antibodies against Polymerase (DNA Directed) iota Interaction Partners

Human Polymerase (DNA Directed) iota (POLI) interaction partners

  1. Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.

  2. Germline genetic variations in human POLI gene may either hinder or promote the translesion synthesis (TLS (show FUS Antibodies)) capability of pol iota (show POLM Antibodies) with various DNA lesions in vitro, emphasizing the potential translational importance of these pol iota (show POLM Antibodies) genetic variations, e.g., individual differences in TLS (show FUS Antibodies), mutation, and cancer susceptibility to genotoxic carcinogens.

  3. a single residue in pol iota (show POLM Antibodies) is able to discriminate between NTPs and dNTPs during DNA synthesis.

  4. Dysregulation of pol iota (show POLM Antibodies) by JNK/c-Jun is involved in carcinogenesis and offer a novel understanding of the role of pol iota (show POLM Antibodies) or c-Jun (show JUN Antibodies) in mutagenesis.

  5. Human Pol iota and yeast Pol zeta complex could function efficiently in the insertion and extension steps, respectively, of ranslesion synthesis and human Pol kappa and Pol eta could also extend past these lesions, albeit much less efficiently.

  6. POLI and MC4R (show MC4R Antibodies) nearby single nucleotide polymorphisms in human chromosome 18 are associated with a moderate risk of type 2 diabetes.

  7. Results show that the physical and functional interaction between pols eta and iota occurs between ubiquitinated forms of either polymerase via their respective ubiquitin-binding domains.

  8. this review briefly discusses the main structural features and possible functional mechanisms of the active center of Pol iota (show POLM Antibodies). [review]

  9. structural mechanism of high-fidelity 8-oxo-G replication by a human DNA polymerase (show POLB Antibodies)

  10. Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.

Mouse (Murine) Polymerase (DNA Directed) iota (POLI) interaction partners

  1. Pol iota occasionally accesses the replication fork to generate a first mutation, and Pol zeta extends the mismatch with a second mutation.

  2. Mouse DNA polymerase iota lacking exon 2 (42 amino acids) is catalytically inactive in vitro.

  3. Exon 2 deletion abrogates both the DNA polymerase (show POLB Antibodies) and dRP (show UTRN Antibodies) lyase activities of Pol iota in the presence of either Mg(2 (show MCOLN1 Antibodies)+) or Mn(2+) ions. Thus, 129-derived strains of mice express catalytically inactive alternatively spliced Pol iota variant.

  4. PolH (show POLH Antibodies) contributes to accurate translesion synthesis (TLS (show FUS Antibodies)) past both T- & C-containing dimers. PolI is involved in error-prone TLS (show FUS Antibodies) past cytosine-containing dimers when Poleta is inactivated.

  5. Poliota causes the Par2 (show F2RL1 Antibodies) effect and inhibits tumorigenesis and mutagenesis

  6. Upon DNA damage, the UBDs (UBM domains) of polymerase iota (Pol iota) interact with ubiquitinated proliferating cell nuclear antigen (show PCNA Antibodies) to regulate the interchange between processive DNA polymerases and translesional synthesis

  7. In the presence of Mg2 (show MCOLN1 Antibodies)+, the enzyme was active only in testicles and brain, whereas in the presence of Mn2+ the activity was found in all organs.

  8. Data suggest that either DNA polymerase iota does not participate in hypermutation, or its role is nonessential and can be readily assumed by another low-fidelity polymerase.

  9. Nucleotide polymorphisms in DNA polymerase iota is associated with lung tumorigenesis in mouse and humans

  10. Pol kappa (show POLL Antibodies) and Pol iota double-deficient mice had the normal somatic hypermutation frequency

Polymerase (DNA Directed) iota (POLI) Antigen Profile

Antigen Summary

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).

Alternative names and synonyms associated with Polymerase (DNA Directed) iota (POLI)

  • polymerase (DNA directed) iota (POLI) antibody
  • polymerase (DNA directed) iota (poli) antibody
  • DNA polymerase iota (poli) antibody
  • DNA polymerase iota (DNApol-iota) antibody
  • DNA polymerase iota (AFUA_4G11140) antibody
  • DNA polymerase iota (AaeL_AAEL006715) antibody
  • polymerase (DNA directed) iota (Pol-iota) antibody
  • polymerase (DNA directed), iota (Poli) antibody
  • GB12093 antibody
  • NV16187 antibody
  • poli antibody
  • RAD3OB antibody
  • Rad30b antibody
  • wu:fc27h11 antibody
  • zgc:110185 antibody

Protein level used designations for POLI

DNA polymerase iota , polymerase (DNA directed) iota , DNA polymerase iota-like , RAD30 homolog B , eta2 , polymerase (DNA-directed), iota

455429 Pan troglodytes
515909 Bos taurus
613070 Xenopus (Silurana) tropicalis
100195208 Salmo salar
550532 Danio rerio
551219 Apis mellifera
3509040 Aspergillus fumigatus Af293
5568276 Aedes aegypti
100116820 Nasonia vitripennis
100411468 Callithrix jacchus
100466548 Ailuropoda melanoleuca
100525374 Sus scrofa
100600494 Nomascus leucogenys
11201 Homo sapiens
100683243 Canis lupus familiaris
26447 Mus musculus
291526 Rattus norvegicus
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