POLI Products
(Polymerase (DNA Directed) iota (POLI))
Categories
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
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Featured POLI Categories
POLI Antibodies
High quality antibodies with extensive validation data.
POLI Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended POLI Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
- (5)
Cat. No.
ABIN564869
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6264338
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7150251
Quantity
100 μg
Datasheet
Datasheet
Recommended POLI ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6203766
Quantity
96 tests
Datasheet
Datasheet
Recommended POLI Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124512
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315648
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315650
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our POLI products
: "DNA polymerase ι is acetylated in response to SN2 alkylating agents." in: Scientific reports, Vol. 9, Issue 1, pp. 4789, (2019) (PubMed).: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).
: "Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication." in: Molecular and cellular biology, Vol. 35, Issue 4, pp. 699-715, (2015) (PubMed).
: "Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin." in: Nature communications, Vol. 5, pp. 5437, (2014) (PubMed).
: "DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity." in: Nucleic acids research, Vol. 40, Issue 1, pp. 170-80, (2011) (PubMed).
: "Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation." in: Journal of nucleic acids, Vol. 2010, pp. 750296, (2010) (PubMed).
: "DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11552-7, (2009) (PubMed).
: "Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations." in: Cancer research, Vol. 67, Issue 7, pp. 3018-26, (2007) (PubMed).
: "The role of DNA polymerase iota in UV mutational spectra." in: Mutation research, Vol. 599, Issue 1-2, pp. 58-65, (2006) (PubMed).
: "Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template." in: The EMBO journal, Vol. 20, Issue 11, pp. 2914-22, (2001) (PubMed).
Synonyms and alternative names related to POLI
DNA polymerase iota (POLI), polymerase (DNA directed) iota (poli), DNA polymerase iota (LOC551219), DNA polymerase iota (AFUA_4G11140), DNA polymerase iota (LOC5568276), polymerase (DNA directed) iota (Pol-iota), polymerase (DNA directed), iota (Poli), DNA polymerase iota (Poli), GB12093, NV16187, poli, RAD3OB, RAD30B, Rad30b, wu:fc27h11, zgc:110185Protein level used designations for POLI
- DNA polymerase iota
- polymerase (DNA directed) iota
- DNA polymerase iota-like
- RAD30 homolog B
- eta2
- polymerase (DNA-directed), iota
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