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Browse our anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antibodies

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anti-Adrenergic, Beta, Receptor Kinase 1 Antibodies (ADRBK1)
On are 130 Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antibodies from 22 different suppliers available. Additionally we are shipping Adrenergic, Beta, Receptor Kinase 1 Kits (15) and Adrenergic, Beta, Receptor Kinase 1 Proteins (9) and many more products for this protein. A total of 169 Adrenergic, Beta, Receptor Kinase 1 products are currently listed.
Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, Grk2
list all antibodies Gene Name GeneID UniProt
ADRBK1 110355  
ADRBK1 156 P25098
ADRBK1 25238 P26817

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Most Popular Reactivities for anti-Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antibodies

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All available anti-Adrenergic, Beta, Receptor Kinase 1 Antibodies

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Top referenced anti-Adrenergic, Beta, Receptor Kinase 1 Antibodies

  1. Human Polyclonal ADRBK1 Primary Antibody for IHC (p), WB - ABIN1882061 : Eichmann, Lorenz, Hoffmann, Brockmann, Krasel, Lohse, Quitterer: The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site. in The Journal of biological chemistry 2003 (PubMed)
    Show all 6 references for ABIN1882061

  2. Human Monoclonal ADRBK1 Primary Antibody for ICC, IHC - ABIN969178 : Chen, Long, Wu, Jiang, Ma: EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation. in Molecular biology of the cell 2008 (PubMed)
    Show all 2 references for ABIN969178

  3. Dog (Canine) Polyclonal ADRBK1 Primary Antibody for WB - ABIN374657 : Iaccarino, Barbato, Cipolletta, De Amicis, Margulies, Leosco, Trimarco, Koch: Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. in European heart journal 2005 (PubMed)

More Antibodies against Adrenergic, Beta, Receptor Kinase 1 Interaction Partners

Mouse (Murine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. GRK2 down-regulation is cardioprotective during diet-induced obesity, reinforcing the protective effect of maintaining low levels of GRK2 under nutritional stress, and showing a role for this kinase in obesity-induced cardiac remodeling and steatosis.

  2. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q (show GNAQ Antibodies)) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure.

  3. GRK2 is localized in the mitochondria and its kinase activity negatively impacts the function of this organelle by increasing superoxide levels and altering substrate utilization for energy production.

  4. Erythropoietin (show EPO Antibodies) seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.

  5. In vitro, GRK2 inhibits Epac1 (show RAPGEF3 Antibodies)-to-Rap1 (show TERF2IP Antibodies) signaling by phosphorylation of Epac1 (show RAPGEF3 Antibodies) at Ser (show SIGLEC1 Antibodies)-108 in the Disheveled/Egl-10/pleckstrin (show PLEK Antibodies) domain. GRK2 inhibits Epac1 (show RAPGEF3 Antibodies)-mediated sensitization of Piezo2 (show FAM38B Antibodies) which contributes to inflammatory mechanical hyperalgesia.

  6. GRK2 ablation increases circadian amplitude and decreases circadian period. GRK2 suppresses mPeriod1 transcription,PERIOD1/2 nuclear trafficking and promotes PERIOD2 phosphorylation.

  7. These results suggest GRK2 contributes to melanopsin (show OPN4 Antibodies) deactivation, but that other mechanisms account for most of modulation of melanopsin (show OPN4 Antibodies) activity in ipRGCs.

  8. data suggest that inhibiting GRK2 could reverse an established insulin (show INS Antibodies)-resistant and obese phenotype

  9. Post-MI AdipoR1 (show ADIPOR1 Antibodies) phosphorylation positively correlated with the expression level of GRK2. AdipoR1 (show ADIPOR1 Antibodies) is phosphorylatively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeling and HF progression.

  10. findings indicate that the balance between mechanisms regulating vascular tone are shifted to favor vasoconstriction in the absence of GRK2 expression and that this leads to the age-dependent development of hypertension

Cow (Bovine) Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK (show GRK4 Antibodies).

  2. Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.

  3. G alpha q/11 interacts with this protein. A novel surface on a regulator of G protein signals a homology domain for binding G alpha subunits (GRK2 kinase}

  4. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits.

  5. intramolecular interactions could play a role in regulating G protein-coupled receptor kinase 2 (GRK2).

  6. epithelial Na-channels are maintained in the active state by Grk2; Grk2 phosphorylates the C terminus of the channel beta subunit (show POLG Antibodies) and renders the channels insensitive to inhibition by Nedd4-2 (show NEDD4L Antibodies).

  7. Crystallographic and biochemical studies provide evidence that the major domain interfaces of G protein-coupled beta adrenergic receptor kinase 1 (GRK2) remain associated during Gbetagamma binding and activation of GRK2.

  8. Resultrs suggest that activated platelet-derived growth factor receptor-beta (show PDGFRB Antibodies) (PDGFRbeta) phosphorylates GRK2 tyrosyl residues and thereby activates GRK2, which then serine-phosphorylates and desensitizes the PDGFRbeta.

  9. GRK2-as5 has a role in membrane trafficking of the mu-opioid receptor (show OPRM1 Antibodies)

  10. atomic structure of GRK2 in complex with Galphaq (show GNAQ Antibodies) and Gbetagamma, in which activated Galpha (show SUCLG1 Antibodies) subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq (show GNAQ Antibodies), Gbetagamma

Human Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) interaction partners

  1. Our data suggest that GRK2 acts as an important onco-modulator by strengthening the functionality of key players in breast tumorigenesis such as HDAC6 (show HDAC6 Antibodies) and Pin1 (show PIN1 Antibodies).

  2. GRK2 may inhibit IGF1 (show IGF1 Antibodies)-induced human hepatocellular carcinoma cell growth and migration through downregulation of EGR1 (show EGR1 Antibodies).

  3. It is a critical factor in diabetic endothelial dysfunction and plays a role in many physiological functions including regulation of G-protein-coupled receptors (GPCRs). (review)

  4. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology.

  5. Suggest role for GRK2 in the regulating cardiac hypertrophy.

  6. the dual-specific GRK2 and ERK (show EPHB2 Antibodies) cascade inhibitor, RKIP (Raf kinase inhibitor protein (show PEBP1 Antibodies)), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg (show PPARG Antibodies)-regulated genes.

  7. Acute mental stress significantly increased GRK2 density in in peripheral blood mononuclear cells of young adult males.

  8. It plays a role in progression of Vasculature which is affected by insulin (show INS Antibodies) resistance and type 2 diabetes expresses high levels of GRK2

  9. Data suggest that, by targeting/repressing GRK2, microRNA-K3 of Kaposi sarcoma-associated herpesvirus (KSHV) facilitates migration and invasion of vascular endothelial cells via activation of CXCR2 (show CXCR2 Antibodies)/AKT (show AKT1 Antibodies) signaling.

  10. Acute aerobic exercise induces a greater GRK2 expression in women than men, while increased cardiorespiratory fitness is associated with exercise-induced GRK2 expression in PBMCs

Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antigen Profile

Antigen Summary

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Alternative names and synonyms associated with Adrenergic, Beta, Receptor Kinase 1 (ADRBK1)

  • beta-adrenergic receptor kinase 1 (Tsp_00497) antibody
  • adrenergic, beta, receptor kinase 1 (adrbk1) antibody
  • adrenergic receptor kinase, beta 1 (Adrbk1) antibody
  • adrenergic, beta, receptor kinase 1 (ADRBK1) antibody
  • adrenergic, beta, receptor kinase 1 (Adrbk1) antibody
  • Adrbk-1 antibody
  • Bark-1 antibody
  • BARK1 antibody
  • BETA-ARK1 antibody
  • betaARK1 antibody
  • GRK-2 antibody
  • Grk2 antibody

Protein level used designations for ADRBK1

beta-adrenergic receptor kinase 1 , adrenergic, beta, receptor kinase 1 , G-protein-coupled receptor kinase 2 , beta ARK , beta ARK1 , beta-AR kinase-1 , beta-ARK-1 , beta-adrenergic receptor kinase-1 , G-protein coupled receptor kinase 2 , adrenergic receptor kinase, beta 1 , beta-adrenergic receptor kinase 1 beta ARK1

10901826 Trichinella spiralis
100555775 Anolis carolinensis
110355 Mus musculus
282682 Bos taurus
156 Homo sapiens
25238 Rattus norvegicus
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