Browse our anti-Insulin Receptor Substrate 1 (IRS1) Antibodies

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anti-Insulin Receptor Substrate 1 Antibodies (IRS1)
On are 564 Insulin Receptor Substrate 1 (IRS1) Antibodies from 30 different suppliers available. Additionally we are shipping Insulin Receptor Substrate 1 Kits (49) and Insulin Receptor Substrate 1 Proteins (6) and many more products for this protein. A total of 643 Insulin Receptor Substrate 1 products are currently listed.
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu

All available anti-Insulin Receptor Substrate 1 Antibodies

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Top referenced anti-Insulin Receptor Substrate 1 Antibodies

  1. Human Polyclonal IRS1 Primary Antibody for IF, IHC (p) - ABIN197466 : Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 4 references for 197466

  2. Human Polyclonal IRS1 Primary Antibody for WB - ABIN196858 : Tzatsos, Kandror: Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. in Molecular and cellular biology 2005 (PubMed)
    Show all 3 references for 196858

  3. Human Polyclonal IRS1 Primary Antibody for IF, IHC - ABIN1531876 : Simon-Szabó, Kokas, Mandl, Kéri, Csala: Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. in PLoS ONE 2014 (PubMed)
    Show all 2 references for 1531876

  4. Human Polyclonal IRS1 Primary Antibody for EIA - ABIN118052 : Cho, Nam, An, Lim: Replicable and shape-controllable fabrication of electrospun fibrous scaffolds for tissue engineering. in Journal of nanoscience and nanotechnology 2013 (PubMed)
    Show all 2 references for 118052

  5. Human Polyclonal IRS1 Primary Antibody for ELISA, WB - ABIN129580 : Shah, Hunter: Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. in Molecular and cellular biology 2006 (PubMed)

  6. Human Polyclonal IRS1 Primary Antibody for ELISA, WB - ABIN1532095 : Araki, Sun, Haag, Chuang, Zhang, Yang-Feng, White, Kahn: Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. in Diabetes 1993 (PubMed)

More Antibodies against Insulin Receptor Substrate 1 Interaction Partners

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. TBC1D4 (show TBC1D4 Antibodies), insulin receptor (show INSR Antibodies) and GLUT4 (show SLC2A4 Antibodies) showed altered expression in some tissues in pre-diabetic pigs.

  2. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.

  2. G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.

  3. The results suggest that high glucose compromises the insulin (show INS Antibodies) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.

  4. The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.

  5. IRS-1 and IRS-2 (show IRS2 Antibodies) signaling interaction with the microtubule cytoskeleton and its response to AKT (show AKT1 Antibodies) determines the response to microtubule disruption in breast carcinoma cells

  6. Findings suggest that the induction of microRNA miR (show MLXIP Antibodies)-1271 by saturated fatty acid palmitate promotes the development of insulin (show INS Antibodies) resistance by targeting insulin receptor (INSR (show INSR Antibodies)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.

  7. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (show INS Antibodies), IRS2 (show IRS2 Antibodies), PPAR-G (show ARF6 Antibodies) and CAPN10 (show CAPN10 Antibodies) failed to show any association with PCOS in our studied population.

  8. Consistent with these observations, LPIN1 (show LPIN1 Antibodies) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (show LPIN1 Antibodies) may be a promising drug target for anticancer therapy

  9. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (show IRS2 Antibodies) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (show INSR Antibodies) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

  10. IRS1 Gene Polymorphism is associated with Autism Spectrum Disorder.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (show PDPK1 Antibodies)/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1 (show PDPK1 Antibodies). This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati

  2. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (show INS Antibodies) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation

  3. Decreased miR (show MLXIP Antibodies)-33 levels can up-regulate IRS-2 (show IRS2 Antibodies) expression, which appears to compensate for the defects of the insulin (show INS Antibodies) signaling pathway in Irs-1 deficient mice.

  4. Acute knockdown of Insr (show INSR Antibodies) or both Irs1 and Irs2 (show IRS2 Antibodies) in adipocytes increased Adipoq (show ADIPOQ Antibodies) mRNA expression but reduced adiponectin (show ADIPOQ Antibodies) secretion.

  5. Concentration of SOCS-3 (show SOCS3 Antibodies) protein and coimmunoprecipitation of SOCS-3 (show SOCS3 Antibodies) protein with both the IR-beta subunit (show POLG Antibodies) as well as IRS-1 was found to be decreased by 4-HIL

  6. Authors propose that insulin (show INS Antibodies)/IGF-1 (show IGF1 Antibodies) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (show PROP1 Antibodies) longevity phenotype.

  7. within the hepatic compartment, mTORC1 --> S6K (show RPS6KB1 Antibodies) signaling regulates Akt (show AKT1 Antibodies) largely through IRS (show IARS Antibodies)-independent means with little effect upon physiologic insulin (show INS Antibodies) sensitivity.

  8. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (show FAM126A Antibodies) development and progression.

  9. Insulin receptor substrate-1-mediated insulin (show INS Antibodies) signal transduction may be an important factor in the treatment of cognitive decline induced by insulin (show INS Antibodies) resistance.

  10. Full Length Irs-1 transcript functions as a bifunctional RNA during myogenic differentiation.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO Antibodies) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 Antibodies) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) Antigen Profile

Antigen Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2) antibody
  • insulin receptor substrate 1 (IRS1) antibody
  • insulin receptor substrate 1 (Irs1) antibody
  • insulin receptor substrate 1 (irs1) antibody
  • G972R antibody
  • HIRS-1 antibody
  • irs-1 antibody
  • IRS1 antibody
  • irs1-a antibody
  • IRS1IRM antibody
  • irsu antibody

Protein level used designations for IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
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