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IRS1 antibody (pSer307)

IRS1 Reactivity: Human, Mouse, Rat, Goat ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN749873
  • Target See all IRS1 Antibodies
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Binding Specificity
    • 31
    • 27
    • 23
    • 21
    • 21
    • 19
    • 18
    • 17
    • 16
    • 16
    • 16
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer307
    Reactivity
    • 291
    • 232
    • 208
    • 23
    • 19
    • 18
    • 17
    • 16
    • 15
    • 15
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Goat
    Host
    • 291
    • 12
    Rabbit
    Clonality
    • 284
    • 19
    Polyclonal
    Conjugate
    • 137
    • 14
    • 12
    • 12
    • 12
    • 12
    • 12
    • 12
    • 11
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 9
    This IRS1 antibody is un-conjugated
    Application
    • 172
    • 125
    • 103
    • 92
    • 91
    • 67
    • 57
    • 51
    • 23
    • 20
    • 13
    • 7
    • 4
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This phosphorylation site is homologous to Ser302 in Mouse and Rat.
    Cross-Reactivity
    Goat, Human, Mouse, Rat
    Predicted Reactivity
    Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser307 [TE(p-S)IT]
    Isotype
    IgG
    Top Product
    Discover our top product IRS1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Zhang, Qin, Zhang, Li, Zhang, Zhao: "Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes." in: Molecules (Basel, Switzerland), Vol. 23, Issue 10, (2018) (PubMed).

    Luo, Yang, Tang, Yao, Kong, He, Zhou: "Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats." in: International immunopharmacology, Vol. 28, Issue 1, pp. 744-50, (2015) (PubMed).

  • Target
    IRS1 (Insulin Receptor Substrate 1 (IRS1))
    Alternative Name
    IRS-1 (IRS1 Products)
    Synonyms
    HIRS-1 antibody, G972R antibody, IRS-1 antibody, IRS1IRM antibody, irs1 antibody, irsu antibody, IRS1 antibody, irs-1 antibody, irs1-a antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 1 S homeolog antibody, IRS1 antibody, Irs1 antibody, irs2 antibody, irs1.S antibody
    Background

    Synonyms: HIRS-1, Insulin receptor substrate 1, IRS-1, IRS1

    Background: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

    Gene ID
    3667
    UniProt
    P35568
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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