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anti-Human LAT2 Antibodies:
anti-Rat (Rattus) LAT2 Antibodies:
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Human Monoclonal LAT2 Primary Antibody for ICC, FACS - ABIN94439
Duque-Afonso, Yalcin, Berg, Abdelkarim, Heidenreich, Lübbert: The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO. in Oncogene 2011
Show all 6 Pubmed References
Mouse (Murine) Polyclonal LAT2 Primary Antibody for ICC, WB - ABIN125755
Horejsí, Zhang, Schraven: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. in Nature reviews. Immunology 2004
Show all 5 Pubmed References
Human Monoclonal LAT2 Primary Antibody for FACS, ICC - ABIN94440
Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. in Molecular and cellular biology 2007
Show all 4 Pubmed References
Human Monoclonal LAT2 Primary Antibody for FACS, IF - ABIN120727
Brdicka, Imrich, Angelisová, Brdicková, Horváth, Spicka, Hilgert, Lusková, Dráber, Novák, Engels, Wienands, Simeoni, Osterreicher, Aguado, Malissen, Schraven, Horejsí: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. in The Journal of experimental medicine 2002
Show all 3 Pubmed References
Human Polyclonal LAT2 Primary Antibody for IHC (p), WB - ABIN302075
Tkaczyk, Horejsi, Iwaki, Draber, Samelson, Satterthwaite, Nahm, Metcalfe, Gilfillan: NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. in Blood 2004
Show all 3 Pubmed References
Mouse (Murine) Polyclonal LAT2 Primary Antibody for WB - ABIN125754
Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. in The Journal of experimental medicine 2004
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LAT1 (show LAT Antibodies) and LAT2 were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.
The detergent-induced stabilization of the purified human 4F2hc (show SLC3A2 Antibodies)-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution
The AML1 (show RUNX1 Antibodies)/ETO (show RUNX1T1 Antibodies) target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy.
NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK (show EPHB2 Antibodies).
LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2 (show GRB2 Antibodies)-ERK (show EPHB2 Antibodies)-cPLA2 (show PLA2G4A Antibodies) signalling cascade at early stages of H. pylori infection.
data show that NTAL (non-T cell activation linker) appears to be a structural and possibly also functional homologue of LAT (linker for activation of T cells (show LAT Antibodies))in non-T cells [non-T cell activation linker]
LAB links BCR (show BCR Antibodies) engagement to downstream signaling pathways.
LAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr (show TYR Antibodies)(136), Tyr (show TYR Antibodies)(193), and Tyr (show TYR Antibodies)(233). Mutation of these three tyrosines abolished Grb2 (show GRB2 Antibodies) binding and LAB function
LAB resembled a LAT (show ORC3 Antibodies) molecule unable to bind phospholipase C (show PLC Antibodies)-gamma1.
NTAL is a negative regulator of FcepsilonRI (show FCER1A Antibodies) activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations.
Cerebral cortex hyperthyroidism of newborn mct8 (show MCT8 Antibodies)-deficient mice transiently suppressed by lat2 (show SLC7A8 Antibodies) inactivation.
Our data define a novel link between LAB and beta-catenin (show CTNNB1 Antibodies) nuclear accumulation in dendritic cells that facilitates IFN-gamma (show IFNG Antibodies) responses during anti-fungal immunity
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI (show FCER1A Antibodies), tetraspanin CD9 (show CD9 Antibodies), transmembrane adaptor proteins NTAL and LAT (show LAT Antibodies), and cytoskeleton-regulatory proteins of the ERM (show ETV5 Antibodies) family
Dihydrotestosterone treatment increased the expression of LAT2 (show SLC7A8 Antibodies).
The expression of Mct8 (show MCT8 Antibodies) and L-type amino acid transporters Lat2 (show SLC7A8 Antibodies) and Lat1 (show SLC7A5 Antibodies) are determined in brain neurons during development.
a crucial role of NTAL in signaling, via RhoA (show RHOA Antibodies), to mast cell cytoskeleton.
While SLP-76 (show LCP2 Antibodies) and LAT1 (show SLC7A5 Antibodies) depend on each other for many of their functions, LAT2 (show SLC7A8 Antibodies)/SLP-76 (show LCP2 Antibodies) interactions and SLP-76 (show LCP2 Antibodies)-independent LAT1 (show SLC7A5 Antibodies) functions also mediate a positive signaling pathway downstream of FcepsilonRI (show FCER1A Antibodies) in mast cells.
LAB is a critical, LAT (show LAT Antibodies)-independent regulator of TREM-2 (show TREM2 Antibodies) signaling and macrophage development capable of controlling subsequent inflammatory responses
NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells.
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.
Williams-Beuren syndrome chromosomal region 15 protein
, Williams-Beuren syndrome chromosomal region 5 protein
, linker for activation of B-cells
, linker for activation of T cells, transmembrane adaptor 2
, linker for activation of T-cells family member 2
, membrane-associated adapter molecule
, non-T-cell activation linker
, Williams-Beuren syndrome chromosome region 5 homolog
, non-T cell activation linker
, linker for activation of T cells family, member 2
, L-type amino acid transporter subunit
, Williams-Beuren syndrome chromosome region 5-like protein
, Williams-Beuren syndrome chromosome region 15 homolog
, williams-Beuren syndrome chromosomal region 15 protein homolog