Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Mouse (Murine) IL-13 Protein expressed in Escherichia coli (E. coli) - ABIN1305069
Doherty, Kastelein, Menon, Andrade, Coffman: Modulation of murine macrophage function by IL-13. in Journal of immunology (Baltimore, Md. : 1950) 1994
Show all 3 Pubmed References
These results suggested that IL-13 +1923C/T polymorphism contributed to the development of asthma.
IL13 AA of rs20541 and STAT4 (show STAT4 Proteins) TT of rs925847 are potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling. The genetic variants of STAT4 (show STAT4 Proteins) TT did not respond to high-dose ICSs.
The diagnostic performance of sputum IL-13 was superior to both sputum eosinophils and FeNO levels for the identification of well-controlled asthma. Sputum IL-13 levels could serve as a useful biomarker for asthma control assessment.
15LO1 inhibition (by short interfering RNA and chemical inhibitor) decreased IL-13-induced forkhead box protein A3 (FOXA3 (show FOXA3 Proteins)) expression and enhanced FOXA2 (show FOXA2 Proteins) expression. These changes were associated with reductions in both mucin 5AC and periostin (show POSTN Proteins).
Clarithromycin suppressed IL-13-induced periostin (show POSTN Proteins) production in human lung fibroblasts, in part by inhibiting STAT6 (show STAT6 Proteins) phosphorylation. This suggests a novel mechanism of the immunomodulatory effect of clarithromycin in asthmatic airway inflammation and fibrosis.
Simvastatin reversed IL-13-suppressed adenosine deaminase (show ADA Proteins) activity, leading to the down-regulation of adenosine signaling and inhibition osteopontin (show SPP1 Proteins) expression through the direct inhibition of IL-13-activated STAT6 (show STAT6 Proteins) pathway in COPD (show ARCN1 Proteins).
Serum IL-5 (show IL5 Proteins) and IL-13 are reliable biomarkers for the blood eosinophilia asthma phenotype.
IL-13 suppressed cyp27b1 (show CYP27B1 Proteins) expression in CD14 (show NDUFA2 Proteins)(+) cells. IL-13 increased expression of miR (show MLXIP Proteins)-19a in CD14 (show NDUFA2 Proteins)(+) cells. IL-13 suppresses cyp27b1 (show CYP27B1 Proteins) expression in peripheral CD14 (show NDUFA2 Proteins)(+) cells via up regulating miR (show MLXIP Proteins)-19a expression.
Leptin (show LEP Proteins) knockdown suppressed MUC5AC production and secretion induced by IL-13 in human bronchial epithelial cells.
demonstrate a strong association between the ratio of Acinetobacter to Proteobacteria and IL-13 production and the probability of IL-13 production after allergen exposure. IL-13 concentrations in serum were also significantly correlated with the diversity of bacterial DNA. Together, these results underscore the relationship between immune responses to allergens and bacterial exposure during perinatal development.
Data indicate that interleukin-33 (IL-33 (show IL33 Proteins))-induced Interleukin-13 (IL-13) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR (show EGFR Proteins)) expression.
this study shows that environmental IL-13 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 (show IL4 Proteins) and IL-13 are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
this study shows that ST2 (show SULT2A1 Proteins) regulates early IL-13 production in fungus-induced allergic airway inflammation
These observations suggest that IL-4 (show IL4 Proteins) and IL-13 likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (show HAND1 Proteins) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
MIF (show MIF Proteins)-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (show GATA3 Proteins) expression and IL-13 production in the mesenteric lymph nodes
findings suggest that a leukotriene B4 receptor-2-linked cascade plays a pivotal role in LPS/TLR4 (show TLR4 Proteins) signaling for IL-13 synthesis in mast cells, thereby potentially exacerbating allergic response.
Study found IL-13 to be critically involved in the development of chemical-induced asthma, as shown by using IL-13 KO mice, and more specifically in the effector phase as confirmed by anti- IL-13 antibody treatment.
these studies show that fibrosis, steatosis, cholestasis, and ductular reaction are simultaneously controlled but distinctly regulated by interleukin-13 signaling
Our data support that impaired clearance of inhaled allergens triggering IL-13 production by multiple cell types in the airways plays an important role in the pathogenesis of type 2 airway inflammation and suggests therapeutic improvement of mucociliary clearance as a novel treatment strategy for children with allergen-induced asthma.
T helper (Th) type 2 cell cytokine IL-13 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 Proteins) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
, T-cell activation protein P600