Browse our IL2 Proteins (IL2)

Full name:
Interleukin 2 Proteins (IL2)
On are 188 Interleukin 2 (IL2) Proteins from 26 different suppliers available. Additionally we are shipping IL2 Antibodies (844) and IL2 Kits (294) and many more products for this protein. A total of 1346 IL2 products are currently listed.
Il-2, il2, lymphokine, POIL2, TCGF
list all proteins Gene Name GeneID UniProt
IL2 3558 P60568
IL2 16183 P04351
Rat IL2 IL2 116562 P17108

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IL2 Proteins (IL2) by Origin

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Top referenced IL2 Proteins

  1. Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120 : Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988 (PubMed)
    Show all 7 references for 1305120

  2. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121 : Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978 (PubMed)
    Show all 5 references for 1305121

  3. Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2666705 : Lowenthal, Zubler, Nabholz, MacDonald: Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. in Nature 1985 (PubMed)
    Show all 5 references for 2666705

  4. Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117 : Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985 (PubMed)
    Show all 4 references for 1305117

  5. Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2667500 : Alcaide, Maganto-Garcia, Newton, Travers, Croce, Bu, Luscinskas, Lichtman: Difference in Th1 and Th17 lymphocyte adhesion to endothelium. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)
    Show all 4 references for 2667500

  6. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN413488 : Du, Lopez-Verges, Pitcher, Johnson, Jung, Zhou, Hsu, Czuczman, Cheson, Kaplan, Lanier, Venstrom: CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. in Cancer immunology research 2014 (PubMed)
    Show all 2 references for 413488

  7. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645 : Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014 (PubMed)

More Proteins for IL2 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Interleukin 2 (IL2) interaction partners

  1. IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s

Cow (Bovine) Interleukin 2 (IL2) interaction partners

  1. Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.

Human Interleukin 2 (IL2) interaction partners

  1. upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (show CXCR4 Proteins) via phosphorylation of S339-CXCR4 (show CXCR4 Proteins) in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2), IL-4 (show IL4 Proteins), and IL-10 (show IL10 Proteins) messenger RNA (mRNA) transcripts.

  2. IL2 induces disruption of adherens junctions, concomitant with cytoskeletal reorganization, ultimately leading to increased endothelial cell permeability.

  3. findings extend understanding of the differential modes of action between IL-2 and IL-15 (show IL15 Proteins), and highlight how, although sharing the CD122 (show IL2RB Proteins)/CD132 (show IL2RG Proteins) receptor, they elicit such different immune actions

  4. DNA-PKcs (show PRKDC Proteins) is a potent regulator of IL-2 production in T lymphocytes.

  5. Yeast-expressed human IL-2 fusion toxin effectively targetedCD25(+) cutaneous T cell lymphoma.

  6. study provides evidence that membrane-coated microvesicles released by apoptotic neutrophils suppress a subset of resting Th cells by downregulating IL-2 and IL-2R expression

  7. In T1D, low IL-2 responsiveness was most pronounced in memory T effector cells. Reduced IL-2 responses in memory T effector cells were not rescued by resting, remained lower after activation and proliferation, and were absent in type 2 diabetes.

  8. the elevated level of IL-2+ and IL-21 (show IL17C Proteins)+ T cells and a positive correlation between IL-21 (show IL17C Proteins)+ cells with clinical activity index in ulcerative colitis patients may contribute to the pathogenesis of disease.

  9. analysis of the contribution of IL2Rgamma to the dynamic formation of IL2-IL2R (show IL2RA Proteins) complexes

  10. lack of local IL-2 enhances regulatory T-cell susceptibility to Fas (show FAS Proteins)-mediated apoptosis induced by epithelial cells

Mouse (Murine) Interleukin 2 (IL2) interaction partners

  1. findings extend understanding of the differential modes of action between IL-2 and IL-15 (show IL15 Proteins), and highlight how, although sharing the CD122 (show IL2RB Proteins)/CD132 (show IL2RG Proteins) receptor, they elicit such different immune actions

  2. studies revealed a new epigenetic pathway in the control of IL-2 production in systemic lupus erythematosus whereby low levels of miR (show MLXIP Proteins)-200a-3p accumulate the binding of the ZEB1-CtBP2 (show CTBP2 Proteins) complex to the IL-2 promoter and suppress IL-2 production

  3. data suggest that the use of Golgi transport inhibitors results in an underestimation of the presence of type 2 cytokine-secreting cells and highlight IL-2 as a critical component in optimal cytokine production by Th2 and Th9 cells in vitro and in vivo

  4. These results suggested that TSC-22 (show TSC22D1 Proteins) could counteract the protective effect of GILZ (show TSC22D3 Proteins) on IL-2-deprivation-induced apoptosis.

  5. this study shows that IL-2 modulates the TCR signaling threshold for CD8 (show CD8A Proteins) but not CD4 (show CD4 Proteins) T cell Proliferation on a single-cell level

  6. These data demonstrate an important synergetic role of TGF-beta (show TGFB1 Proteins) and IL-2 in the generation, activation and stability of Treg cells, as well as their subsequent development into follicular regulatory T cells.

  7. Mecamylamine, a nAChR (show CHRNA4 Proteins) inhibitor, suppressed not only these [Ca(2 (show CA2 Proteins)+)]i transients, but also IL-2 release and T cell proliferation

  8. Flavonoid glycosides of Alchornea floribunda did not result in detectable Il2 secretion by treated splenic T-lymphocytes.

  9. We also discuss the role of interleukin 2 (IL-2), which is decisive for the function of Treg and has been used therapeutically in preliminary trials in human SLE. The identification of novel Treg markers and the development of novel therapeutic approaches, which restore the balance between Treg and autoreactive Tcells are future goals for research in SLE.

  10. Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2 (show TNFAIP8L2 Proteins)) gene was down-regulated, the expression of the CD69 antigen (show CD69 Proteins) was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 and IFN-gamma (show IFNG Proteins) were enhanced.

Pig (Porcine) Interleukin 2 (IL2) interaction partners

  1. We observed that besides TCR stimulation Tregs require IL-2 for activation.

  2. The isolation and characterization of interleukin 2 from Tibetan swine are reported.

Rabbit Interleukin 2 (IL2) interaction partners

  1. IL-2 activates the STAT3 (show STAT3 Proteins) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.

IL2 Protein Profile

Protein Summary

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Alternative names and synonyms associated with IL2

  • interleukin 2 (IL2)
  • interleukin 2 (il2)
  • interleukin 2 (Il2)
  • Il-2 protein
  • il2 protein
  • lymphokine protein
  • POIL2 protein
  • TCGF protein

Protein level used designations for Interleukin 2 Proteins (IL2)

interleukin 2 , interleukin-2 , T-cell growth factor , T cell growth factor , aldesleukin , involved in regulation of T-cell clonal expansion , TCGF , IL-2 , interleukin-2 precursor protein

461472 Pan troglodytes
100126754 Papio anubis
100302642 Oncorhynchus mykiss
100303688 Meleagris gallopavo
280822 Bos taurus
3558 Homo sapiens
16183 Mus musculus
751114 Felis catus
443401 Ovis aries
396868 Sus scrofa
116562 Rattus norvegicus
403989 Canis lupus familiaris
100379540 Cavia porcellus
100302458 Oryctolagus cuniculus
100034204 Equus caballus
708017 Macaca mulatta
101413757 Dasypus novemcinctus
100480862 Ailuropoda melanoleuca
101274648 Orcinus orca
373958 Gallus gallus
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