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Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120
Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121
Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978
Show all 5 references for ABIN1305121
Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2666705
Lowenthal, Zubler, Nabholz, MacDonald: Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. in Nature 1985
Show all 5 references for ABIN2666705
Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117
Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985
Show all 4 references for ABIN1305117
Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2667500
Alcaide, Maganto-Garcia, Newton, Travers, Croce, Bu, Luscinskas, Lichtman: Difference in Th1 and Th17 lymphocyte adhesion to endothelium. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 4 references for ABIN2667500
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN413488
Du, Lopez-Verges, Pitcher, Johnson, Jung, Zhou, Hsu, Czuczman, Cheson, Kaplan, Lanier, Venstrom: CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. in Cancer immunology research 2014
Show all 2 references for ABIN413488
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645
Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014
IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s
Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
IL-2 may be involved in the pathogenesis of recurrent oral ulcer.
After 4 weeks of star fruit juice consumption, a significant reduction in NO, TNF-alpha (show TNF Proteins) and IL-23 (show IL23A Proteins) was found; however, there was no change in IL-2.
There was a significant association of IL2 rs6534349 polymorphism with increased asthma risk and high load M. pneumoniae infectionin the GG genotype. IL-2 serum expression levels were significantly higher in M. pneumoniae negative subjects.
Triple costimulation via CD80 (show CD80 Proteins), 4-1BB (show TNFRSF9 Proteins), and CD83 (show CD83 Proteins) ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2.
Single Nucleotide Polymorphisms in interleukin 2 gene involved in the immune response are generally not associated with intraprostatic inflammation in men without a Prostate cancer diagnosis.
TIM-3 (show HAVCR2 Proteins) is a negative regulator of TCR-function by attenuating activation signals mediated by CD3 (show CD3 Proteins)/CD28 (show CD28 Proteins) co-stimulation.
IL-2-330 T/G polymorphism may not be associated with acute rejection risk in renal transplant recipients (Meta-Analysis)
Age and CMV serostatus influence the expression of NKp30 (show NCR3 Proteins), NKp46 (show NCR1 Proteins) and DNAM-1 (show CD226 Proteins) activating receptors on resting and IL-2 activated natural killer cells.
Moxifloxacin restored IL-2 expression and T-cell proliferation in the presence of LPS (show IRF6 Proteins) by blocking p38 MAPK (show MAPK14 Proteins)
The results suggested that the IL-2 +114T/G polymorphism may contribute to increased HBV-related HCC (show FAM126A Proteins) risk through regulating the serum IL-2 levels.
This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 (show JAK3 Proteins) kinase activity in IL-2-driven T cell proliferation.
There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
Dominance of regulatory T cells in carcinogen-induced fibrosarcomas is not T-bet or Il-2 dependent.
TCF1 (show HNF1A Proteins) is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 and Blimp1 (show PRDM1 Proteins).
These results may provide an additional understanding of the characteristics of the various fractions of isolated Tregs based on phenotype and function and the role of varying levels of exogenous IL-2 on the suppressive activity of these cells.
findings demonstrate that distinct niches within the lymphoid organ T zone support distinct cell fate decisions, and they establish a function for dendritic-cell-derived CD25 (show IL2RA Proteins) in controlling IL-2 availability and T-cell differentiation
IL-2 signaling modulates TH1 (show HAND1 Proteins) cell, follicular helper T cell and central memory T cell gene expression.
Ndrg1 (show NDRG1 Proteins) is a T-cell clonal anergy factor negatively regulated by IL-2.
Innate cell-derived IL-2 is a critical cofactor in regulating innate lymphoid cell function in pulmonary type 2 pathology
glucosamine interferes with N-glycosylation of CD25 (show IL2RA Proteins), and thereby attenuates IL-2 downstream signaling
We observed that besides TCR stimulation Tregs require IL-2 for activation.
The isolation and characterization of interleukin 2 from Tibetan swine are reported.
IL-2 activates the STAT3 (show STAT3 Proteins) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
, T-cell growth factor
, T cell growth factor
, involved in regulation of T-cell clonal expansion
, interleukin-2 precursor protein