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Browse our IL2 Proteins (IL2)

Full name:
Interleukin 2 Proteins (IL2)
On are 185 Interleukin 2 (IL2) Proteins from 27 different suppliers available. Additionally we are shipping IL2 Antibodies (688) and IL2 Kits (269) and many more products for this protein. A total of 1163 IL2 products are currently listed.
Il-2, il2, lymphokine, POIL2, TCGF
list all proteins Gene Name GeneID UniProt
IL2 3558 P60568
IL2 16183 P04351
Rat IL2 IL2 116562 P17108

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IL2 Proteins (IL2) by Origin

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Top referenced IL2 Proteins

  1. Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120 : Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988 (PubMed)
    Show all 7 references for ABIN1305120

  2. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121 : Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978 (PubMed)
    Show all 5 references for ABIN1305121

  3. Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2666705 : Lowenthal, Zubler, Nabholz, MacDonald: Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. in Nature 1985 (PubMed)
    Show all 5 references for ABIN2666705

  4. Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117 : Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985 (PubMed)
    Show all 4 references for ABIN1305117

  5. Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2667500 : Alcaide, Maganto-Garcia, Newton, Travers, Croce, Bu, Luscinskas, Lichtman: Difference in Th1 and Th17 lymphocyte adhesion to endothelium. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)
    Show all 4 references for ABIN2667500

  6. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN413488 : Du, Lopez-Verges, Pitcher, Johnson, Jung, Zhou, Hsu, Czuczman, Cheson, Kaplan, Lanier, Venstrom: CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. in Cancer immunology research 2014 (PubMed)
    Show all 2 references for ABIN413488

  7. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645 : Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014 (PubMed)

More Proteins for IL2 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Interleukin 2 (IL2) interaction partners

  1. IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s

Cow (Bovine) Interleukin 2 (IL2) interaction partners

  1. Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.

Human Interleukin 2 (IL2) interaction partners

  1. IL-2 may be involved in the pathogenesis of recurrent oral ulcer.

  2. After 4 weeks of star fruit juice consumption, a significant reduction in NO, TNF-alpha (show TNF Proteins) and IL-23 (show IL23A Proteins) was found; however, there was no change in IL-2.

  3. There was a significant association of IL2 rs6534349 polymorphism with increased asthma risk and high load M. pneumoniae infectionin the GG genotype. IL-2 serum expression levels were significantly higher in M. pneumoniae negative subjects.

  4. Triple costimulation via CD80 (show CD80 Proteins), 4-1BB (show TNFRSF9 Proteins), and CD83 (show CD83 Proteins) ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2.

  5. Single Nucleotide Polymorphisms in interleukin 2 gene involved in the immune response are generally not associated with intraprostatic inflammation in men without a Prostate cancer diagnosis.

  6. TIM-3 (show HAVCR2 Proteins) is a negative regulator of TCR-function by attenuating activation signals mediated by CD3 (show CD3 Proteins)/CD28 (show CD28 Proteins) co-stimulation.

  7. IL-2-330 T/G polymorphism may not be associated with acute rejection risk in renal transplant recipients (Meta-Analysis)

  8. Age and CMV serostatus influence the expression of NKp30 (show NCR3 Proteins), NKp46 (show NCR1 Proteins) and DNAM-1 (show CD226 Proteins) activating receptors on resting and IL-2 activated natural killer cells.

  9. Moxifloxacin restored IL-2 expression and T-cell proliferation in the presence of LPS (show IRF6 Proteins) by blocking p38 MAPK (show MAPK14 Proteins)

  10. The results suggested that the IL-2 +114T/G polymorphism may contribute to increased HBV-related HCC (show FAM126A Proteins) risk through regulating the serum IL-2 levels.

Mouse (Murine) Interleukin 2 (IL2) interaction partners

  1. This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 (show JAK3 Proteins) kinase activity in IL-2-driven T cell proliferation.

  2. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  3. Dominance of regulatory T cells in carcinogen-induced fibrosarcomas is not T-bet or Il-2 dependent.

  4. TCF1 (show HNF1A Proteins) is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 and Blimp1 (show PRDM1 Proteins).

  5. These results may provide an additional understanding of the characteristics of the various fractions of isolated Tregs based on phenotype and function and the role of varying levels of exogenous IL-2 on the suppressive activity of these cells.

  6. findings demonstrate that distinct niches within the lymphoid organ T zone support distinct cell fate decisions, and they establish a function for dendritic-cell-derived CD25 (show IL2RA Proteins) in controlling IL-2 availability and T-cell differentiation

  7. IL-2 signaling modulates TH1 (show HAND1 Proteins) cell, follicular helper T cell and central memory T cell gene expression.

  8. Ndrg1 (show NDRG1 Proteins) is a T-cell clonal anergy factor negatively regulated by IL-2.

  9. Innate cell-derived IL-2 is a critical cofactor in regulating innate lymphoid cell function in pulmonary type 2 pathology

  10. glucosamine interferes with N-glycosylation of CD25 (show IL2RA Proteins), and thereby attenuates IL-2 downstream signaling

Pig (Porcine) Interleukin 2 (IL2) interaction partners

  1. We observed that besides TCR stimulation Tregs require IL-2 for activation.

  2. The isolation and characterization of interleukin 2 from Tibetan swine are reported.

Rabbit Interleukin 2 (IL2) interaction partners

  1. IL-2 activates the STAT3 (show STAT3 Proteins) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.

IL2 Protein Profile

Protein Summary

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Alternative names and synonyms associated with IL2

  • interleukin 2 (IL2)
  • interleukin 2 (il2)
  • interleukin 2 (Il2)
  • Il-2 protein
  • il2 protein
  • lymphokine protein
  • POIL2 protein
  • TCGF protein

Protein level used designations for Interleukin 2 Proteins (IL2)

interleukin 2 , interleukin-2 , T-cell growth factor , T cell growth factor , aldesleukin , involved in regulation of T-cell clonal expansion , TCGF , IL-2 , interleukin-2 precursor protein

461472 Pan troglodytes
100126754 Papio anubis
100302642 Oncorhynchus mykiss
100303688 Meleagris gallopavo
280822 Bos taurus
3558 Homo sapiens
16183 Mus musculus
751114 Felis catus
443401 Ovis aries
396868 Sus scrofa
116562 Rattus norvegicus
403989 Canis lupus familiaris
100379540 Cavia porcellus
100302458 Oryctolagus cuniculus
100034204 Equus caballus
708017 Macaca mulatta
101413757 Dasypus novemcinctus
100480862 Ailuropoda melanoleuca
101274648 Orcinus orca
373958 Gallus gallus
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