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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2667498
DCruz, Klein: Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. in Nature immunology 2005
Show all 7 references for ABIN2667498
Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120
Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988
Show all 7 references for ABIN1305120
Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2666705
Lowenthal, Zubler, Nabholz, MacDonald: Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. in Nature 1985
Show all 5 references for ABIN2666705
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121
Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978
Show all 5 references for ABIN1305121
Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117
Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985
Show all 4 references for ABIN1305117
Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2667500
Alcaide, Maganto-Garcia, Newton, Travers, Croce, Bu, Luscinskas, Lichtman: Difference in Th1 and Th17 lymphocyte adhesion to endothelium. in Journal of immunology (Baltimore, Md. : 1950) 2012
Show all 4 references for ABIN2667500
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645
Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014
IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s
Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
The IL-2 rs2069762 G allele appeared to be a protective mutation against aplastic anemia, but no significant differences were found in other four IL-2 and Il-8 (show IL8 Proteins) SNPs studied.
Pristimerin inhibits IL-2 induced T cell activation and generation of lymphokine-activated killer cells by disrupting multiple cell signaling pathways induced by IL-2.
IL-2 or induced killer cells combination therapy was efficacious in treating NSCLC and improved overall survival. Further analysis of trials having adequate information and data need to be done to confirm these findings.
Treatment of memory CD4 (show CD4 Proteins) T cells with the concentration of kynurenine found in plasma inhibited IL-2 signaling through the production of reactive oxygen species.
Ochratoxin A mediates MAPK (show MAPK1 Proteins) activation, modulates IL-2 and TNF-alpha (show TNF Proteins) mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human CD4 (show CD4 Proteins) positive T-cell lymphoma cell line.
Study identified IFNG (show IFNG Proteins) and IL-2 as putative inflammatory agents associated with depressive symptoms in COPD (show ARCN1 Proteins) patients.
The results of the current study suggest that certain SNPs of IL-2 gene have association with individuals' susceptibility to juvenile idiopathic arthritis.
this study shows that IL-2 cytokine gene polymorphisms could affect individual susceptibility to Juvenile systemic lupus erythematosus in Iranian children
The mRNA expression levels of IL-1beta (show IL1B Proteins), IL-2, IL-6 (show IL6 Proteins), and TNF-a (show TNF Proteins) were downregulated at 50 mg/L F for 48 h. Therefore, F inhibited HeLa cell growth; as such, F could be used to alleviate the inhibition of pro-inflammatory cytokine expression.
IL-2 therapy should be used as a first- or second-line therapy following IFN-a (show IFNA6 Proteins) therapy. IL-2 may have a lower response if it is used after molecular-targeted therapy or other treatments
Mecamylamine, a nAChR (show CHRNA4 Proteins) inhibitor, suppressed not only these [Ca(2 (show CA2 Proteins)+)]i transients, but also IL-2 release and T cell proliferation
Flavonoid glycosides of Alchornea floribunda did not result in detectable Il2 secretion by treated splenic T-lymphocytes.
We also discuss the role of interleukin 2 (IL-2), which is decisive for the function of Treg and has been used therapeutically in preliminary trials in human SLE. The identification of novel Treg markers and the development of novel therapeutic approaches, which restore the balance between Treg and autoreactive Tcells are future goals for research in SLE.
Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2 (show TNFAIP8L2 Proteins)) gene was down-regulated, the expression of the CD69 antigen (show CD69 Proteins) was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 and IFN-gamma (show IFNG Proteins) were enhanced.
This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 (show JAK3 Proteins) kinase activity in IL-2-driven T cell proliferation.
There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
Dominance of regulatory T cells in carcinogen-induced fibrosarcomas is not T-bet or Il-2 dependent.
TCF1 (show HNF1A Proteins) is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 and Blimp1 (show PRDM1 Proteins).
These results may provide an additional understanding of the characteristics of the various fractions of isolated Tregs based on phenotype and function and the role of varying levels of exogenous IL-2 on the suppressive activity of these cells.
findings demonstrate that distinct niches within the lymphoid organ T zone support distinct cell fate decisions, and they establish a function for dendritic-cell-derived CD25 (show IL2RA Proteins) in controlling IL-2 availability and T-cell differentiation
We observed that besides TCR stimulation Tregs require IL-2 for activation.
The isolation and characterization of interleukin 2 from Tibetan swine are reported.
IL-2 activates the STAT3 (show STAT3 Proteins) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
, T-cell growth factor
, T cell growth factor
, involved in regulation of T-cell clonal expansion
, interleukin-2 precursor protein