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Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120
Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121
Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978
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Pig (Porcine) IL2 Protein expressed in - ABIN2965535
Stěpánová, Sinkora: The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs. in Developmental and comparative immunology 2011
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117
Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985
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Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN988052
Brewin, Mancao, Straathof, Karlsson, Samarasinghe, Amrolia, Pule: Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease. in Blood 2009
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Human IL2 Protein expressed in - ABIN988056
Yu, Chen, Horton, Bansal, McElrath, Reichman, Goepfert, Jin: Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection. in Journal of medical virology 2006
Show all 5 Pubmed References
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN413488
Du, Lopez-Verges, Pitcher, Johnson, Jung, Zhou, Hsu, Czuczman, Cheson, Kaplan, Lanier, Venstrom: CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. in Cancer immunology research 2014
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Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645
Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014
Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN804324
Mendoza-Naranjo, Saéz, Johansson, Ramírez, Mandakovic, Pereda, López, Kiessling, Sáez, Salazar-Onfray: Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2007
Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN803864
Gakamsky, Luescher, Pramanik, Kopito, Lemonnier, Vogel, Rigler, Pecht: CD8 kinetically promotes ligand binding to the T-cell antigen receptor. in Biophysical journal 2005
IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s
Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.
F42K can circumvent the expansion and negative immunoregulatory effects of highly suppressive ICOS (show CTLA4 Proteins)+ Tregs, while promoting NK cell expansion and function. F42K also induces a unique gene expression profile and does not activate many IL2-induced genes, although it has the capacity to activate NK cells and NK cell-associated activation genes, costimulatory molecules, and NK-mediated cytolytic function
Chimeric fusion protein of interleukin 2 (IL2) and its receptor interleukin 2 receptor, beta protein (IL2Rbeta) enhances antitumor activity of natural killer NK92 cells.
Il2 was not a useful discriminative markers for active tuberculosis among pulmonary tuberculosis suspects.
IL-2 and IL-10 (show IL10 Proteins) could work synergistically to improve the survival, proliferation, and cytotoxicity of activated CD8 (show CD8A Proteins)(+) T cells, an effect suppressible by CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(+) Treg cells
results show that IL-23 (show IL23A Proteins) accounts for the main aspects of human and murine lupus including the expansion of double negative T cells, decreased IL-2, and increased IL-17 (show IL17A Proteins) production
Report efficient retroviral vector transduction of primary human natural killer cells that were stimulated by a combination of IL-2 and engineered K562 cells expressing membrane-bound IL-21 (show IL17C Proteins) for cancer immunotherapy.
upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (show CXCR4 Proteins) via phosphorylation of S339-CXCR4 (show CXCR4 Proteins) in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2), IL-4 (show IL4 Proteins), and IL-10 (show IL10 Proteins) messenger RNA (mRNA) transcripts.
IL2 induces disruption of adherens junctions, concomitant with cytoskeletal reorganization, ultimately leading to increased endothelial cell permeability.
findings extend understanding of the differential modes of action between IL-2 and IL-15 (show IL15 Proteins), and highlight how, although sharing the CD122 (show IL2RB Proteins)/CD132 (show IL2RG Proteins) receptor, they elicit such different immune actions
DNA-PKcs (show PRKDC Proteins) is a potent regulator of IL-2 production in T lymphocytes.
Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice.
At single cell level, IL-2 is binary (digital) and CD25 (show IL2RA Proteins) is graded expressed, whereas at population level both parameters show graded expression correlating with the antigen amount.
IL-2/anti-IL-2 complexes protected lupus-prone mice against lupus nephritis by expanding Tregs.
Data indicate that IL-2 can augment the gammadeltaT-17 response in favor of short-lived effectors with limited plasticity, particularly in the presence of IL-1beta (show IL1B Proteins) and IL-23 (show IL23A Proteins). In this way, IL-2 may act to curtail the innate-like response of gammadeltaT-17 cells upon arrival of IL-2-producing adaptive immune cells at the site of inflammation.
studies revealed a new epigenetic pathway in the control of IL-2 production in systemic lupus erythematosus whereby low levels of miR (show MLXIP Proteins)-200a-3p accumulate the binding of the ZEB1-CtBP2 (show CTBP2 Proteins) complex to the IL-2 promoter and suppress IL-2 production
data suggest that the use of Golgi transport inhibitors results in an underestimation of the presence of type 2 cytokine-secreting cells and highlight IL-2 as a critical component in optimal cytokine production by Th2 and Th9 cells in vitro and in vivo
These results suggested that TSC-22 (show TSC22D1 Proteins) could counteract the protective effect of GILZ (show TSC22D3 Proteins) on IL-2-deprivation-induced apoptosis.
this study shows that IL-2 modulates the TCR signaling threshold for CD8 (show CD8A Proteins) but not CD4 (show CD4 Proteins) T cell Proliferation on a single-cell level
We observed that besides TCR stimulation Tregs require IL-2 for activation.
The isolation and characterization of interleukin 2 from Tibetan swine are reported.
IL-2 activates the STAT3 (show STAT3 Proteins) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
, T-cell growth factor
, T cell growth factor
, involved in regulation of T-cell clonal expansion
, interleukin-2 precursor protein