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Browse our IL2 Proteins (IL2)

Full name:
Interleukin 2 Proteins (IL2)
On are 177 Interleukin 2 (IL2) Proteins from 25 different suppliers available. Additionally we are shipping IL2 Antibodies (800) and IL2 Kits (288) and many more products for this protein. A total of 1285 IL2 products are currently listed.
Il-2, il2, lymphokine, POIL2, TCGF
list all proteins Gene Name GeneID UniProt
IL2 3558 P60568
IL2 16183 P04351
Rat IL2 IL2 116562 P17108

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IL2 Proteins (IL2) by Origin

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Top referenced IL2 Proteins

  1. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2667498 : DCruz, Klein: Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. in Nature immunology 2005 (PubMed)
    Show all 7 references for ABIN2667498

  2. Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305120 : Thompson, Di Sabato: Purification and characterization of two forms of rat interleukin-2. in Cellular immunology 1988 (PubMed)
    Show all 7 references for ABIN1305120

  3. Rat (Rattus) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2666705 : Lowenthal, Zubler, Nabholz, MacDonald: Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. in Nature 1985 (PubMed)
    Show all 5 references for ABIN2666705

  4. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305121 : Gillis, Ferm, Ou, Smith: T cell growth factor: parameters of production and a quantitative microassay for activity. in Journal of immunology (Baltimore, Md. : 1950) 1978 (PubMed)
    Show all 5 references for ABIN1305121

  5. Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1305117 : Kashima, Nishi-Takaoka, Fujita, Taki, Yamada, Hamuro, Taniguchi: Unique structure of murine interleukin-2 as deduced from cloned cDNAs. in Nature 1985 (PubMed)
    Show all 4 references for ABIN1305117

  6. Mouse (Murine) IL2 Protein expressed in Escherichia coli (E. coli) - ABIN2667500 : Alcaide, Maganto-Garcia, Newton, Travers, Croce, Bu, Luscinskas, Lichtman: Difference in Th1 and Th17 lymphocyte adhesion to endothelium. in Journal of immunology (Baltimore, Md. : 1950) 2012 (PubMed)
    Show all 4 references for ABIN2667500

  7. Human IL2 Protein expressed in Escherichia coli (E. coli) - ABIN1589645 : Haustein, Ramer, Linnebacher, Manda, Hinz: Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. in Biochemical pharmacology 2014 (PubMed)

More Proteins for IL2 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) Interleukin 2 (IL2) interaction partners

  1. IL-2 had moderate protein homology (30.9% identity/48.3% similarity) with Fugu IL-2, the only IL-2 homologue identified in fish to date, with lower homology to avian (17.8% identity/23.2% similarity) and mammalian (34.2 identity/46.5% similarity) IL-2s

Cow (Bovine) Interleukin 2 (IL2) interaction partners

  1. Pretreatment of neonatal PBMC with IL-1beta (show IL1B Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor.

Human Interleukin 2 (IL2) interaction partners

  1. The IL-2 rs2069762 G allele appeared to be a protective mutation against aplastic anemia, but no significant differences were found in other four IL-2 and Il-8 (show IL8 Proteins) SNPs studied.

  2. Pristimerin inhibits IL-2 induced T cell activation and generation of lymphokine-activated killer cells by disrupting multiple cell signaling pathways induced by IL-2.

  3. IL-2 or induced killer cells combination therapy was efficacious in treating NSCLC and improved overall survival. Further analysis of trials having adequate information and data need to be done to confirm these findings.

  4. Treatment of memory CD4 (show CD4 Proteins) T cells with the concentration of kynurenine found in plasma inhibited IL-2 signaling through the production of reactive oxygen species.

  5. Ochratoxin A mediates MAPK (show MAPK1 Proteins) activation, modulates IL-2 and TNF-alpha (show TNF Proteins) mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human CD4 (show CD4 Proteins) positive T-cell lymphoma cell line.

  6. Study identified IFNG (show IFNG Proteins) and IL-2 as putative inflammatory agents associated with depressive symptoms in COPD (show ARCN1 Proteins) patients.

  7. The results of the current study suggest that certain SNPs of IL-2 gene have association with individuals' susceptibility to juvenile idiopathic arthritis.

  8. this study shows that IL-2 cytokine gene polymorphisms could affect individual susceptibility to Juvenile systemic lupus erythematosus in Iranian children

  9. The mRNA expression levels of IL-1beta (show IL1B Proteins), IL-2, IL-6 (show IL6 Proteins), and TNF-a (show TNF Proteins) were downregulated at 50 mg/L F for 48 h. Therefore, F inhibited HeLa cell growth; as such, F could be used to alleviate the inhibition of pro-inflammatory cytokine expression.

  10. IL-2 therapy should be used as a first- or second-line therapy following IFN-a (show IFNA6 Proteins) therapy. IL-2 may have a lower response if it is used after molecular-targeted therapy or other treatments

Mouse (Murine) Interleukin 2 (IL2) interaction partners

  1. Mecamylamine, a nAChR (show CHRNA4 Proteins) inhibitor, suppressed not only these [Ca(2 (show CA2 Proteins)+)]i transients, but also IL-2 release and T cell proliferation

  2. Flavonoid glycosides of Alchornea floribunda did not result in detectable Il2 secretion by treated splenic T-lymphocytes.

  3. We also discuss the role of interleukin 2 (IL-2), which is decisive for the function of Treg and has been used therapeutically in preliminary trials in human SLE. The identification of novel Treg markers and the development of novel therapeutic approaches, which restore the balance between Treg and autoreactive Tcells are future goals for research in SLE.

  4. Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2 (show TNFAIP8L2 Proteins)) gene was down-regulated, the expression of the CD69 antigen (show CD69 Proteins) was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 and IFN-gamma (show IFNG Proteins) were enhanced.

  5. This study evaluated a chemical genetic toolkit that evaluated a biphasic requirement for JAK3 (show JAK3 Proteins) kinase activity in IL-2-driven T cell proliferation.

  6. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  7. Dominance of regulatory T cells in carcinogen-induced fibrosarcomas is not T-bet or Il-2 dependent.

  8. TCF1 (show HNF1A Proteins) is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 and Blimp1 (show PRDM1 Proteins).

  9. These results may provide an additional understanding of the characteristics of the various fractions of isolated Tregs based on phenotype and function and the role of varying levels of exogenous IL-2 on the suppressive activity of these cells.

  10. findings demonstrate that distinct niches within the lymphoid organ T zone support distinct cell fate decisions, and they establish a function for dendritic-cell-derived CD25 (show IL2RA Proteins) in controlling IL-2 availability and T-cell differentiation

Pig (Porcine) Interleukin 2 (IL2) interaction partners

  1. We observed that besides TCR stimulation Tregs require IL-2 for activation.

  2. The isolation and characterization of interleukin 2 from Tibetan swine are reported.

Rabbit Interleukin 2 (IL2) interaction partners

  1. IL-2 activates the STAT3 (show STAT3 Proteins) pathway, protects the lens epithelium cells and reduce the damage caused by inflammation reactions.

IL2 Protein Profile

Protein Summary

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Alternative names and synonyms associated with IL2

  • interleukin 2 (IL2)
  • interleukin 2 (il2)
  • interleukin 2 (Il2)
  • Il-2 protein
  • il2 protein
  • lymphokine protein
  • POIL2 protein
  • TCGF protein

Protein level used designations for Interleukin 2 Proteins (IL2)

interleukin 2 , interleukin-2 , T-cell growth factor , T cell growth factor , aldesleukin , involved in regulation of T-cell clonal expansion , TCGF , IL-2 , interleukin-2 precursor protein

461472 Pan troglodytes
100126754 Papio anubis
100302642 Oncorhynchus mykiss
100303688 Meleagris gallopavo
280822 Bos taurus
3558 Homo sapiens
16183 Mus musculus
751114 Felis catus
443401 Ovis aries
396868 Sus scrofa
116562 Rattus norvegicus
403989 Canis lupus familiaris
100379540 Cavia porcellus
100302458 Oryctolagus cuniculus
100034204 Equus caballus
708017 Macaca mulatta
101413757 Dasypus novemcinctus
100480862 Ailuropoda melanoleuca
101274648 Orcinus orca
373958 Gallus gallus
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