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IL-2 Protein

IL2 Origin: Mouse Host: Escherichia coli (E. coli) > 95 % by SDS-PAGE and HPLC analyses. Active
Catalog No. ABIN988052
  • Target See all IL-2 (IL2) Proteins
    IL-2 (IL2) (Interleukin 2 (IL2))
    Biological Activity
    Active
    Origin
    • 32
    • 16
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Source
    • 40
    • 25
    • 22
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Sequence
    APTSSSTSSS TAEAQQQQQQ QQQQQQHLEQ LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSP
    Characteristics
    The ED50 as determined by the dose dependent stimulation of murine CTLL-2 cells is < 0.2 ng/ml, corresponding to a specific activity of > 5.0 x 106 units/mg.
    Purity
    > 95 % by SDS-PAGE and HPLC analyses.
    Endotoxin Level
    Level Less than 1EU/µg of rMuIL-2 as determined by LAL method
    Top Product
    Discover our top product IL2 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at
    Storage
    4 °C
  • Phuan, Ratelade, Rossi, Tradtrantip, Verkman: "Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays." in: The Journal of biological chemistry, Vol. 287, Issue 17, pp. 13829-39, (2012) (PubMed).

    Brewin, Mancao, Straathof, Karlsson, Samarasinghe, Amrolia, Pule: "Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease." in: Blood, Vol. 114, Issue 23, pp. 4792-803, (2009) (PubMed).

  • Target
    IL-2 (IL2) (Interleukin 2 (IL2))
    Alternative Name
    Interleukin-2 (IL-2 ) (IL2 Products)
    Synonyms
    IL2 Protein, IL-2 Protein, il2 Protein, TCGF Protein, lymphokine Protein, Il-2 Protein, POIL2 Protein, interleukin 2 Protein, interleukin-15 Protein, IL2 Protein, il2 Protein, LOC100303688 Protein, Il2 Protein
    Background
    Mature mouse IL-2 shares 56% and 73% aa sequence identity with human and rat IL-2, respectively. It shows strain-specific heterogeneity in an N-terminal region that contains a poly-glutamine stretch. Mouse and human IL-2 exhibit cross-species activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes . The 55 kDa IL-2 Rªis specific for IL-2 and binds with low affinity. The 75 kDa IL-2 Rbeta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. The 64 kDa common gamma chainγc/IL-2 Rγ, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. Upon ligand binding, signal transduction is performed by both IL-2 Rbetaandγc. It drives resting T cells to proliferate and induces IL-2 and IL-2 Rªsynthesis. It contributes to T cell homeostasis by promoting the Fas-induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes . IL-2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Synonym: Interleukin-2 ( IL-2 ), Mouse. Formulation: Lyophilized from a 0.2µm filtered solution in PBS, pH 7.4.
    Molecular Weight
    Approximately 17.2 kDa, a single non-glycosylated polypeptide chain containing 149 amino acids.
    Pathways
    JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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