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anti-Mouse (Murine) PIAS1 Antibodies:
anti-Human PIAS1 Antibodies:
anti-Rat (Rattus) PIAS1 Antibodies:
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Human Polyclonal PIAS1 Primary Antibody for IHC (p), WB - ABIN388054
Miyauchi, Yogosawa, Honda, Nishida, Yasuda: Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. in The Journal of biological chemistry 2002
Show all 7 Pubmed References
these results indicate that PIAS1 is a positive regulator of MYC (show MYC Antibodies).
PIAS1 overexpression exacerbated mutant Huntingtin-associated (show KALRN Antibodies) phenotypes and aberrant protein accumulation
Pias1 expression in primary myoblasts enhances the induction of cardiac muscle genes MyoD (show MYOD1 Antibodies), Myogenin (show MYOG Antibodies) and Myomaker. Endothelial cell specific inactivation of Pias1 in vivo impairs yolk sac (show ADCY10 Antibodies) erythrogenesis, angiogenesis and recapitulates loss of myocardium muscle mass. Pias1 is an essential gene for YS erythropoiesis and vasculogenesis in vivo.
Data suggest overexpression of Pias1 in white adipose tissue (WAT) of obesity/prediabetes improves insulin (show INS Antibodies) resistance; knockdown of Pias1 in normal WAT leads to insulin (show INS Antibodies) resistance; Pias1 expression in WAT is down-regulated by c-Jun N-terminal kinase.
Between the E3 SUMO ligase PIAS1 and STAT-3 (show STAT3 Antibodies).
Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 (show STIP1 Antibodies) in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 (show STIP1 Antibodies) binding site is unable to increase STI1 (show STIP1 Antibodies) nuclear retention.
A novel role of PIAS1 in maintaining the quiescence of dormant hematopoietic stem cells and in the epigenetic repression of the myeloerythroid program.
The present study showed that PIAS1 functions as a SUMO E3 ligase of C/EBPbeta (show CEBPB Antibodies) to regulate adipogenesis.
Piasy (show PIAS4 Antibodies) represses the synergistic activation of PITX2 (show PITX2 Antibodies) with interacting co-factors and Piasy (show PIAS4 Antibodies) represses Pias1 activation of PITX2 (show PITX2 Antibodies) transcriptional activity.
MAPK-activated protein kinase-2 limits endothelial inflammation via the PIAS1 S522 phosphorylation-mediated increase in PIAS1 transrepression and SUMO ligase activity.
PIAS1 is a prognostic biomarker in breast cancer
PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer
HBs protein-induced hPIAS1 transcription requires TAL1 (show TAL1 Antibodies), E47 (show TCF3 Antibodies), MYOG (show MYOG Antibodies), NFI (show NFIC Antibodies), and MAPK (show MAPK1 Antibodies) signal pathways
identified the SUMO ligase PIAS1 as a constituent PML (show PML Antibodies)-NB antiviral protein. This finding distinguishes a SUMO ligase that may mediate signaling events important in promyelocytic leukemia (show PML Antibodies) nuclear body mediated intrinsic immunity.
PIAS1 enhances p300 (show EP300 Antibodies) recruitment to c-Myb (show MYB Antibodies)-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 enhances further its coactivation
Results show that apocrine breast cancer and prostate cancer cells share a core AR cistrome and target gene signature linked to cancer cell growth, and PIAS1 plays a similar coregulatory role for AR in both cancer cell types.
c-Myc (show MYC Antibodies) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 (show SENP7 Antibodies) and RNF4 (show RNF4 Antibodies)
Data demonstrate that PIAS1 interacts with TRF2 (show TERF2 Antibodies) and mediates its sumoylation serving as a molecular switch that controls the level of TRF2 (show TERF2 Antibodies) at telomeres.
This gene encodes a member of the mammalian PIAS
protein inhibitor of activated STAT, 1
, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
, DEAD/H box-binding protein 1
, E3 SUMO-protein ligase PIAS1
, protein inhibitor of activated STAT protein 1
, AR interacting protein
, RNA helicase II-binding protein
, gu-binding protein
, protein inhibitor of activated STAT-1
, zinc finger, MIZ-type containing 3
, SUMO E3 ligase