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Browse our SOCS1 Proteins (SOCS1)

Full name:
Suppressor of Cytokine Signaling 1 Proteins (SOCS1)
On www.antibodies-online.com are 7 Suppressor of Cytokine Signaling 1 (SOCS1) Proteins from 5 different suppliers available. Additionally we are shipping SOCS1 Antibodies (168) and SOCS1 Kits (14) and many more products for this protein. A total of 204 SOCS1 products are currently listed.
Synonyms:
CIS1, Cish1, Cish7, JAB, LOC100228306, Socs-1, SOCS1, socs1b, SSI-1, SSI1, TIP3, zgc:91868
list all proteins Gene Name GeneID UniProt
SOCS1 8651 O15524
SOCS1 12703 O35716
SOCS1 252971 Q9QX78

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SOCS1 Proteins (SOCS1) by Origin

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More Proteins for SOCS1 Interaction Partners

Zebrafish Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. Socs1a transgenic zebrafish have liver steatosis and insulin (show INS Proteins) resistance.

  2. Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (show JAK2 Proteins)-Stat5 (show STAT5B Proteins) pathway.

  3. in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 (show SOCS3 Proteins) proteins.

Rhesus Monkey Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. SOCS1 alleviates RhTRIM5alpha-mediated regulation in the late phase of HIV-1 life cycle probably due to the destabilization of RhTRIM5alpha.

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. The upregulation of SOCS-1 and SOCS-2 (show SOCS2 Proteins) by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.

Human Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. miR (show MLXIP Proteins)-203 and miR (show MLXIP Proteins)-221 regulate SOCS1 and SOCS3 (show SOCS3 Proteins) in essential thrombocythemia

  2. The HBVX gene upregulated the mRNA and protein expression levels of DNMT3A (show DNMT3A Proteins)/3B, downregulated the expression of SOCS1 and increased SOCS1 gene promoter CpG island methylation.

  3. The present study confirmed that both Fas (show FAS Proteins)/FasL (show FASL Proteins) signaling and SOCS1 promoted the high glucose induced mitochondrial dysfunction and apoptosis; results implies the key regulatory role of Fas (show FAS Proteins) signaling and SOCS (show CISH Proteins) in diabetic retinopathy

  4. miR (show MLXIP Proteins)-155 levels were inversely correlated with SOCS1 mRNA expression in oral lichen planus CD4 (show CD4 Proteins)+ T cells.

  5. SOCS1 pro-oncogenic activity correlated with the down-modulation of STAT1 (show STAT1 Proteins) expression. Collectively, these results suggest that SOCS1 may work as an oncogene (show RAB1A Proteins) in CRC (show CALR Proteins).

  6. SOCS1 mutation type qualifies as a single-gene prognostic biomarker in classical Hodgkin lymphoma.

  7. rs423674, or its genetic proxies, may influence MS risk by modulating SOCS1 expression in a cell-specific manner and by influencing dendritic cell function.

  8. SOCS1 promoter methylation is associated with the risk of hepatocellular carcinoma.

  9. Monocytes of juvenile idiopathic arthritis patients expressed higher transcript levels of SOCS1.

  10. SOCS1 is a target of miR (show MLXIP Proteins)-155 in oxidized low density lipoprotein-stimulated macrophages.

Mouse (Murine) Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. The miR (show MLXIP Proteins)-155 inhibitor relieves liver injury by enhancing the expression of SOCS1 and inactivating JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling.

  2. NOS1 (show NOS1 Proteins)-derived nitric oxide promotes NF-kappaB (show NFKB1 Proteins) transcriptional activity through inhibition of Socs1.Cys147 and Cys179 are essential for SOCS1 nitrosation and proteasomal degradation.

  3. mir (show MLXIP Proteins)-155 deficiency attenuates liver ischemia-reperfusion injury through upregulation of SOCS1, which is associated with promotion of M2 macrophage and inhibition of Th17 differentiation

  4. Findings indicate that SOCS1 mediates its tumor suppressor functions, at least partly, by binding to MET and interfering with downstream signaling pathways as well as by promoting the turnover of the activated MET receptor.

  5. increased expression of SOCS-1 in the lungs of mice significantly protects against hyperoxic lung injury.

  6. Overexpression of SOCS1 in transgenic rat eyes attenuated ocular HSV-1 infection

  7. Axl (show AXL Proteins) promotes STAT1 (show STAT1 Proteins) signaling via inhibition of SOCS1 in activated smooth muscle cells in vein graft remodeling.

  8. targeting SOCS (show CISH Proteins) proteins, predominantly SOCS1, to suppress pathological mechanisms involved in atheroma plaque progression and destabilization could be an interesting anti-atherosclerotic strategy

  9. SOCS1/SOCS3 (show SOCS3 Proteins) expression ratios can be used to characterize HSV-1-infected and uninfected macrophages.

  10. alveolar macrophages can secrete SOCS1 and -3 in exosomes and microparticles, respectively, for uptake by alveolar epithelial cells and subsequent inhibition of STAT (show STAT1 Proteins) activation.

SOCS1 Protein Profile

Protein Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Alternative names and synonyms associated with SOCS1

  • suppressor of cytokine signaling 1a (socs1a)
  • suppressor of cytokine signaling 1 (socs1)
  • suppressor of cytokine signaling 1 (SOCS1)
  • suppressor of cytokine signaling 1 (LOC100228306)
  • suppressor of cytokine signaling 1 (socs1-b)
  • suppressor of cytokine signaling 1-like protein (socs1)
  • suppressor of cytokine signaling 1 (Socs1)
  • CIS1 protein
  • Cish1 protein
  • Cish7 protein
  • JAB protein
  • LOC100228306 protein
  • Socs-1 protein
  • SOCS1 protein
  • socs1b protein
  • SSI-1 protein
  • SSI1 protein
  • TIP3 protein
  • zgc:91868 protein

Protein level used designations for SOCS1

suppressor of cytokine signaling 1 , suppressor of cytokine signalling , suppressor of cytokine signaling 1b , suppressor of cytokine signaling 1-like protein , JAK binding protein , JAK-binding protein , STAT induced SH3 protein 1 , STAT-induced STAT inhibitor 1 , TIP-3 , Tec-interacting protein 3 , cytokine-inducible SH2 protein 1 , JAK2-binding protein , cytokine inducible SH2-containing protein 1 , cytokine inducible SH2-containing protein 7

GENE ID SPECIES
445073 Danio rerio
496789 Xenopus (Silurana) tropicalis
711180 Macaca mulatta
737070 Pan troglodytes
100144374 Oryzias latipes
100228306 Taeniopygia guttata
100272210 Oncorhynchus mykiss
100294520 Xenopus laevis
100049621 Takifugu rubripes
8651 Homo sapiens
12703 Mus musculus
416630 Gallus gallus
490006 Canis lupus familiaris
252971 Rattus norvegicus
518795 Bos taurus
100307052 Sus scrofa
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