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Socs1a transgenic zebrafish have liver steatosis and insulin (show INS Proteins) resistance.
Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (show JAK2 Proteins)-Stat5 (show STAT5B Proteins) pathway.
in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 (show SOCS3 Proteins) proteins.
SOCS1 alleviates RhTRIM5alpha-mediated regulation in the late phase of HIV-1 life cycle probably due to the destabilization of RhTRIM5alpha.
The upregulation of SOCS-1 and SOCS-2 (show SOCS2 Proteins) by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
These results suggest that miR146a may regulate SOCS1/STAT3 (show STAT3 Proteins) and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection.
IFN-lambda signaling is regulated by SOCS1 but not by SOCS3 (show SOCS3 Proteins) or USP18 (show USP18 Proteins).
This study evaluation the roles of SOCS1, the regulator of TLR9 (show TLR9 Proteins), RIG-I (show DDX58 Proteins), and CD152 (show CTLA4 Proteins) in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported.
SOCS1 rs33932899 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Studies indicate that suppressors of cytokine signaling (SOCS (show CISH Proteins)) proteins CIS (show CISH Proteins), SOCS1, and SOCS3 (show SOCS3 Proteins) can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4 (show CD4 Proteins)(+) T cells and the maturation of CD8 (show CD8A Proteins)(+) T cells.
Results provide evidence that repression of SHP-1 (show PTPN6 Proteins), SHP-2 (show PTPN11 Proteins) and SOCS-1 gene expression in patient plasma cells supports the constitutive activation of the JAK (show JAK3 Proteins)/STAT3 (show STAT3 Proteins) pathway and probably leads to higher degrees of bone marrow invasion.
Suppressor of cytokine signaling 1 (SOCS1) expression was upregulated in sustained virological responses (SVR) patients compared with non-SVR patients based on a multiplex reverse transcription-polymerase chain reaction analysis. Peripheral blood SOCS1 expression before treatment was not associated with SVR in hepatitis C virus (HCV) genotype 1 patients treated with pegylated IFN-alpha (show IFNA Proteins) and ribavirin.
tumor-suppressor functions of SOCS1 in the liver could be mediated, at least partly, via regulation of the expression, stability and subcellular distribution of p21 (show CDKN1A Proteins) and its paradoxical oncogenic functions, namely, resistance to apoptosis and increased proliferation
Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium cells inhibits some IFNgamma-mediated responses that lead to uveitis development. This notion raises the possibility that SOCS1 overexpression could be a novel target for treating non-infectious uveitis.
nectin-4 (show PVRL4 Proteins) serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Proteins) by regulating the feedback inhibition of SOCS1 in the JAK2 (show JAK2 Proteins)-STAT5a (show STAT5A Proteins) signaling pathway
Study conclude that under pro-proliferative cytokine stimulation at the onset of myeloproliferative diseases SOCS1 acts as a tumor suppressor, while under anti-proliferative conditions it exerts oncogenic function.
results indicate that SOCS1 is one of the essential molecules that maintain regulatory T cell stability, particularly under the inflammatory conditions in which APCs (show APCS Proteins) are highly activated
The Stat3 (show STAT3 Proteins) exerts its activity through the induction of miR (show MLXIP Proteins)- 155, which suppresses suppressor of cytokine signaling (SOCS (show CISH Proteins))1.
Cell type-specific, different roles for viral immediate early (show JUN Proteins) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 and SOCS3 (show SOCS3 Proteins) during murine cytomegalovirus infection.
Loss of SOCS3 (show SOCS3 Proteins) significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 deficiency. We propose a model in which SOCS1 and SOCS3 (show SOCS3 Proteins) operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease
miR (show MLXIP Proteins)-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT (show STAT1 Proteins) and PDCD4 (show PDCD4 Proteins), as well as the production of proinflammation mediators IL-6 (show IL6 Proteins) and TNF-alpha (show TNF Proteins) in atherogenesis.
TLR8 (show TLR8 Proteins) coupling with SOCS-1 inhibits TLR7 (show TLR7 Proteins)-mediated antiviral immunity during WNV infection in mice.
this study shows that genetic modification of dendritic cells with SOCS1 affects their activation and maturation, inhibits T-cell proliferation and induces hypo-responsiveness, and prolongs islet allograft survival
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
suppressor of cytokine signaling 1
, suppressor of cytokine signalling
, suppressor of cytokine signaling 1b
, suppressor of cytokine signaling 1-like protein
, JAK binding protein
, JAK-binding protein
, STAT induced SH3 protein 1
, STAT-induced STAT inhibitor 1
, Tec-interacting protein 3
, cytokine-inducible SH2 protein 1
, JAK2-binding protein
, cytokine inducible SH2-containing protein 1
, cytokine inducible SH2-containing protein 7