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Browse our SOCS1 Proteins (SOCS1)

Full name:
Suppressor of Cytokine Signaling 1 Proteins (SOCS1)
On are 13 Suppressor of Cytokine Signaling 1 (SOCS1) Proteins from 5 different suppliers available. Additionally we are shipping SOCS1 Antibodies (172) and SOCS1 Kits (23) and many more products for this protein. A total of 222 SOCS1 products are currently listed.
CIS1, Cish1, Cish7, JAB, LOC100228306, Socs-1, SOCS1, socs1b, SSI-1, SSI1, TIP3, zgc:91868
list all proteins Gene Name GeneID UniProt
SOCS1 8651 O15524
SOCS1 12703 O35716
SOCS1 252971 Q9QX78

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SOCS1 Proteins (SOCS1) by Origin

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More Proteins for SOCS1 Interaction Partners

Zebrafish Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. Socs1a transgenic zebrafish have liver steatosis and insulin (show INS Proteins) resistance.

  2. Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (show JAK2 Proteins)-Stat5 (show STAT5B Proteins) pathway.

  3. in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 (show SOCS3 Proteins) proteins.

Rhesus Monkey Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. SOCS1 alleviates RhTRIM5alpha-mediated regulation in the late phase of HIV-1 life cycle probably due to the destabilization of RhTRIM5alpha.

Rainbow Trout (Oncorhynchus mykiss) Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. The upregulation of SOCS-1 and SOCS-2 (show SOCS2 Proteins) by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.

Human Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. This study showed that SOCS5 (show SOCS5 Proteins) expression was significantly down-regulated.

  2. this study shows that IL-7 (show IL7 Proteins) induces the expression of SOCS1 through the JAK (show JAK3 Proteins)/STAT-5 (show STAT5A Proteins) pathway

  3. SOCS1 silencing can inhibit proliferation and induce apoptosis of MV3 and A357 melanoma cells in vivo and in vitro by inhibiting extracellular signal-regulated kinase and janus kinase signal transduction and activators of transcription signaling pathways.

  4. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 (show TP53 Proteins) signaling.

  5. The results revealed that although the expression levels of SOCS1, SOCS3 (show SOCS3 Proteins) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 (show PIAS3 Proteins) downregulation is more negatively correlated with STAT3 (show STAT3 Proteins) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

  6. findings provide novel insight into how dysregulated expression of SOCS (show CISH Proteins) increases IL-4 (show IL4 Proteins) responses in allergic monocytes, and this may represent a new therapeutic avenue for managing allergic disease.

  7. Overexpression of SOCS1 has a potent antitumor effect against ESCC.

  8. IL-4 (show IL4 Proteins) signaling plays a crucial role in the regulatory functions of SOCS1 in apoptosis and inflammation in human osteoarthritic chondrocytes. These findings provide a potential therapeutic target for the clinical treatment of osteoarthritis (OA)

  9. We demonstrated that VDR (show CYP27B1 Proteins)/miRNA155-modulated SOCS1 expression is decreased in PBC (show DLAT Proteins) which may lead to insufficient negative regulation of cytokine signaling. These findings suggest that the decreased VDR (show CYP27B1 Proteins) signaling in PBC (show DLAT Proteins) could be of importance in the pathogenesis of PBC (show DLAT Proteins).

  10. Through promoter hypermethylation, the SOCS-1 gene was severely down-regulated in the colorectal cancer tissue samples.

Mouse (Murine) Suppressor of Cytokine Signaling 1 (SOCS1) interaction partners

  1. this study shows that genetic modification of dendritic cells with SOCS1 affects their activation and maturation, inhibits T-cell proliferation and induces hypo-responsiveness, and prolongs islet allograft survival

  2. SOCS1 may promote apoptosis of intestinal epithelial cells at least partly through mediating p53 (show TP53 Proteins) signaling.

  3. Kdm5a (show KDM5A Proteins) associates with p50 (show LSP1 Proteins) and binds to the Socs1 promoter region in resting natural killer cells.

  4. The miR (show MLXIP Proteins)-155 inhibitor relieves liver injury by enhancing the expression of SOCS1 and inactivating JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling.

  5. NOS1 (show NOS1 Proteins)-derived nitric oxide promotes NF-kappaB (show NFKB1 Proteins) transcriptional activity through inhibition of Socs1.Cys147 and Cys179 are essential for SOCS1 nitrosation and proteasomal degradation.

  6. mir (show MLXIP Proteins)-155 deficiency attenuates liver ischemia-reperfusion injury through upregulation of SOCS1, which is associated with promotion of M2 macrophage and inhibition of Th17 differentiation

  7. Findings indicate that SOCS1 mediates its tumor suppressor functions, at least partly, by binding to MET and interfering with downstream signaling pathways as well as by promoting the turnover of the activated MET receptor.

  8. increased expression of SOCS-1 in the lungs of mice significantly protects against hyperoxic lung injury.

  9. Overexpression of SOCS1 in transgenic rat eyes attenuated ocular HSV-1 infection

  10. Axl (show AXL Proteins) promotes STAT1 (show STAT1 Proteins) signaling via inhibition of SOCS1 in activated smooth muscle cells in vein graft remodeling.

SOCS1 Protein Profile

Protein Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Alternative names and synonyms associated with SOCS1

  • suppressor of cytokine signaling 1a (socs1a)
  • suppressor of cytokine signaling 1 (socs1)
  • suppressor of cytokine signaling 1 (SOCS1)
  • suppressor of cytokine signaling 1 (LOC100228306)
  • suppressor of cytokine signaling 1 (socs1-b)
  • suppressor of cytokine signaling 1-like protein (socs1)
  • suppressor of cytokine signaling 1 (Socs1)
  • CIS1 protein
  • Cish1 protein
  • Cish7 protein
  • JAB protein
  • LOC100228306 protein
  • Socs-1 protein
  • SOCS1 protein
  • socs1b protein
  • SSI-1 protein
  • SSI1 protein
  • TIP3 protein
  • zgc:91868 protein

Protein level used designations for SOCS1

suppressor of cytokine signaling 1 , suppressor of cytokine signalling , suppressor of cytokine signaling 1b , suppressor of cytokine signaling 1-like protein , JAK binding protein , JAK-binding protein , STAT induced SH3 protein 1 , STAT-induced STAT inhibitor 1 , TIP-3 , Tec-interacting protein 3 , cytokine-inducible SH2 protein 1 , JAK2-binding protein , cytokine inducible SH2-containing protein 1 , cytokine inducible SH2-containing protein 7

445073 Danio rerio
496789 Xenopus (Silurana) tropicalis
711180 Macaca mulatta
737070 Pan troglodytes
100144374 Oryzias latipes
100228306 Taeniopygia guttata
100272210 Oncorhynchus mykiss
100294520 Xenopus laevis
100049621 Takifugu rubripes
8651 Homo sapiens
12703 Mus musculus
416630 Gallus gallus
490006 Canis lupus familiaris
252971 Rattus norvegicus
518795 Bos taurus
100307052 Sus scrofa
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