SOCS1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2732329

Product Details

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This SOCS1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human SOCS1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Alternative Name: Socs1 (SOCS1 Products)

Synonyms: socs1 Protein, zgc:91868 Protein, jab Protein, cis1 Protein, ssi1 Protein, tip3 Protein, cish1 Protein, ssi-1 Protein, socs-1 Protein, SOCS1 Protein, LOC100228306 Protein, socs1b Protein, CIS1 Protein, CISH1 Protein, JAB Protein, SOCS-1 Protein, SSI-1 Protein, SSI1 Protein, TIP3 Protein, Cish1 Protein, Cish7 Protein, Socs-1 Protein, suppressor of cytokine signaling 1a Protein, suppressor of cytokine signaling 1 Protein, suppressor of cytokine signaling 1 L homeolog Protein, socs1a Protein, socs1 Protein, SOCS1 Protein, socs1.L Protein, Socs1 Protein

Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Molecular Weight: 23.4 kDa

NCBI Accession: NP_003736

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus