SOCS1 Protein (AA 1-211, full length) (His tag)

Catalog No. ABIN5710396

Product Details

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Protein Type: Recombinant

Protein Characteristics: full length, AA 1-211

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SOCS1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ RIVATVGREN LARIPLNPVL RDYLSSFPFQ I

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Alternative Name: SOCS1 (SOCS1 Products)

Synonyms: socs1 Protein, zgc:91868 Protein, jab Protein, cis1 Protein, ssi1 Protein, tip3 Protein, cish1 Protein, ssi-1 Protein, socs-1 Protein, SOCS1 Protein, LOC100228306 Protein, socs1b Protein, CIS1 Protein, CISH1 Protein, JAB Protein, SOCS-1 Protein, SSI-1 Protein, SSI1 Protein, TIP3 Protein, Cish1 Protein, Cish7 Protein, Socs-1 Protein, suppressor of cytokine signaling 1a Protein, suppressor of cytokine signaling 1 Protein, suppressor of cytokine signaling 1 L homeolog Protein, socs1a Protein, socs1 Protein, SOCS1 Protein, socs1.L Protein, Socs1 Protein

Background: SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival . Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Molecular Weight: 27.6 kDa

UniProt: O15524

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus