Browse our anti-SOCS3 (SOCS3) Antibodies

Full name:
anti-Suppressor of Cytokine Signaling 3 Antibodies (SOCS3)
On are 223 Suppressor of Cytokine Signaling 3 (SOCS3) Antibodies from 28 different suppliers available. Additionally we are shipping SOCS3 Kits (51) and SOCS3 Proteins (24) and many more products for this protein. A total of 305 SOCS3 products are currently listed.
ATOD4, Cis3, Cish3, EF-10, Ef10, fj09e12, MGC64393, MGC75749, MGC81248, Socs-3, SOCS3, Ssi-3, Ssi3, wu:fj09e12, xsocs3, zgc:56537
list all antibodies Gene Name GeneID UniProt
SOCS3 9021 O14543
SOCS3 12702 O35718
SOCS3 89829 O88583

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Top referenced anti-SOCS3 Antibodies

  1. Human Polyclonal SOCS3 Primary Antibody for WB - ABIN493472 : Alexander, Hilton: The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. in Annual review of immunology 2004 (PubMed)
    Show all 5 references for 493472

  2. Human Polyclonal SOCS3 Primary Antibody for ELISA, IF (p) - ABIN670416 : Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 4 references for 670416

  3. Human Polyclonal SOCS3 Primary Antibody for IHC, IHC (p) - ABIN4355049 : Harris, Apolzan: Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. in Physiology & behavior 2014 (PubMed)
    Show all 2 references for 4355049

  4. Human Polyclonal SOCS3 Primary Antibody for ELISA, WB - ABIN184566 : Roberts, Robb, Rakar, Hartley, Cluse, Nicola, Metcalf, Hilton, Alexander: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)

  5. Human Monoclonal SOCS3 Primary Antibody for WB - ABIN153119 : Xiang, Dong, Liu, Wang, Shi, Wei, Hu, Gong: Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-?-induced vascular smooth muscle cells. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013 (PubMed)

  6. Human Polyclonal SOCS3 Primary Antibody for IHC, ELISA - ABIN1585262 : van de Loo, Veenbergen, van den Brand, Bennink, Blaney-Davidson, Arntz, van Beuningen, van der Kraan, van den Berg: Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function. in Arthritis and rheumatism 2012 (PubMed)

More Antibodies against SOCS3 Interaction Partners

Zebrafish Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (show SFPQ Antibodies) and Socs3a

  2. stat3 (show STAT3 Antibodies)/socs3 pathway is a key response in all tissue regeneration in zebrafish.

  3. Trpm7 (show TRPM7 Antibodies) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Antibodies)+)-sensitive Socs3a pathway.

  4. SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Antibodies) pathway by chemical inhibitors

  5. The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.

  6. in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Antibodies) and SOCS3 proteins.

Human Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. In M1-activated human monocyte-derived macrophages, SOCS3 silencing decreased expression of proinflammatory markers and increased M2 macrophage markers. SOCS3 knockdown radically affects the temporal dynamics of M1 macrophages' particle engulfment through increased PI3K and Ras-related C3 botulinum toxin substrate 1 (Rac1) activity. SOCS3 drives macrophage inflammatory responses and modulates key phagocytosis signaling.

  2. The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (show IFNA Antibodies) signaling via increased expression of SOCS3 and PP2A (show PPP2R4 Antibodies).

  3. Overexpression of SOCS3 inhibited proliferation, migration, invasion and tumorigenic ability of colorectal cancer cells while increased cell apoptosis. Reduced expression of SOCS3 promoted the growth and metastasis of colorectal cancer.

  4. SOCS3, which is a critical negative regulator of cytokine response to tuberculosis infection and its nearby lncRNA XLOC_012582, were highly expressed in active tuberculosis B cells.

  5. Data show that the suppressor of cytokine signaling-3 (SOCS3) promoter hypermethylation was associated with relatively low mRNA expression in tumor tissues.

  6. Data show that ELOVL7 (show ELOVL7 Antibodies), SOCS3, ACSL4 (show ACSL4 Antibodies) and CLU (show CLU Antibodies) were upregulated while PRKAR1A (show PRKAR1A Antibodies) and ABCG1 (show ABCG1 Antibodies) were downregulated in the phlegm-dampness group.

  7. There are pronounced changes in the expression of SOCS3 only in Non-allergic Asthma.

  8. epigenetic signatures at AQP3 (show AQP3 Antibodies) and SOCS3 engage in low-grade inflammation across different tissues, possible via JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) mediated pathways

  9. SHP2 (show PTPN11 Antibodies), SOCS3 and PIAS3 (show PIAS3 Antibodies) levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 (show PIAS3 Antibodies) downregulation is more reversely correlated with STAT3 (show STAT3 Antibodies) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Antibodies) downregulation and decreased incidence of STAT3 (show STAT3 Antibodies) nuclear translocation, PIAS3 (show PIAS3 Antibodies) is upregulated, the SHP2 (show PTPN11 Antibodies) level remains unchanged and SOCS3 is downregulated.

  10. SOCS3 methylation status was associated with multiple metabolic syndrome traits, including central obesity, fat depots, insulin (show INS Antibodies) responsiveness, and plasma lipids.

Pig (Porcine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. SOCS3 is an important negative regulator of insulin (show INS Antibodies) signaling in porcine adipocytes.

Cow (Bovine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.

  2. Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Antibodies) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.

Mouse (Murine) Suppressor of Cytokine Signaling 3 (SOCS3) interaction partners

  1. Cell type-specific, different roles for viral immediate early (show JUN Antibodies) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 (show SOCS1 Antibodies) and SOCS3 during murine cytomegalovirus infection.

  2. oncostatin M (show OSM Antibodies) mitigated the proliferation of Th17 cells and decreased the expression of IL-17 (show IL17A Antibodies) and IL-21 (show IL21 Antibodies); it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3 (show STAT3 Antibodies), and STAT5 (show STAT5A Antibodies); observations suggest that OSM (show OSM Antibodies) can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3 (show STAT3 Antibodies), and STAT5 (show STAT5A Antibodies)

  3. Results demonstrate a novel tunable form of cross-talk in which alveolar epithelial cells use Prostaglandin E2 (PGE2) as a signal to request SOCS3 from alveolar macrophages to dampen their endogenous inflammatory responses during infection.

  4. Loss of SOCS3 significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 (show SOCS1 Antibodies) deficiency. We propose a model in which SOCS1 (show SOCS1 Antibodies) and SOCS3 operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease

  5. This study showed that leptin (show LEP Antibodies) resistant infertility is caused in part by the leptin (show LEP Antibodies) signaling molecule SOCS3. Deletion of SOCS3 from brain neurons delays the onset of diet-induced infertility.

  6. SOCS3 plays a divergent role in relation to local vs. systemic effects of Ang II (show AGT Antibodies) on the vasculature.

  7. These results indicate that Platelet-activating Factor -mediated endotoxin tolerance is initiated via IDO (show IDO1 Antibodies)- and JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies)-dependent expression of SOCS3.

  8. expression in leptin receptor-positive cells contributes to fasting-induced hyperphagia and weight regain

  9. a novel negative feedback loop mediated by STAT3 (show STAT3 Antibodies)-SOCS3, which is tightly controlled by SENP1 (show SENP1 Antibodies) via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Antibodies)), in IFN-gamma (show IFNG Antibodies) signaling, is reported.

  10. Vasoproliferative retinopathies may benefit from a CNTF (show CNTF Antibodies)-dependent and SOCS3-mediated angiomodulatory effect.

SOCS3 Antigen Profile

Antigen Summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

Alternative names and synonyms associated with SOCS3

  • suppressor of cytokine signaling 3a (socs3a) antibody
  • suppressor of cytokine signaling 3 (socs3) antibody
  • suppressor of cytokine signaling 3 (SOCS3) antibody
  • suppressor of cytokine signaling 3a (socs3) antibody
  • suppressor of cytokine signaling 3 (LOC100227853) antibody
  • suppressor of cytokine signaling 3 (Socs3) antibody
  • ATOD4 antibody
  • Cis3 antibody
  • Cish3 antibody
  • EF-10 antibody
  • Ef10 antibody
  • fj09e12 antibody
  • MGC64393 antibody
  • MGC75749 antibody
  • MGC81248 antibody
  • Socs-3 antibody
  • SOCS3 antibody
  • Ssi-3 antibody
  • Ssi3 antibody
  • wu:fj09e12 antibody
  • xsocs3 antibody
  • zgc:56537 antibody

Protein level used designations for SOCS3

suppressor of cytokine signaling 3 , suppressor of cytokine signaling 3a , STAT-induced STAT inhibitor 3 , cytokine-inducible SH2 protein 3 , cytokine signaling suppressor , SOCS-3 , CIS-3 , E2a-Pbx1 target gene in fibroblasts 10 , cytokine inducible SH2-containing protein 3 , suppressors of cytokine signaling 3

335409 Danio rerio
380467 Xenopus laevis
394588 Xenopus (Silurana) tropicalis
414533 Xenopus laevis
448204 Xenopus (Silurana) tropicalis
454921 Pan troglodytes
100050730 Equus caballus
100192332 Gasterosteus aculeatus
100272212 Oncorhynchus mykiss
100294595 Ovis aries
100528984 Ictalurus punctatus
100227853 Taeniopygia guttata
9021 Homo sapiens
442949 Canis lupus familiaris
493186 Sus scrofa
282081 Bos taurus
12702 Mus musculus
89829 Rattus norvegicus
395299 Gallus gallus
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