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anti-Human SOCS3 Antibodies:
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Human Polyclonal SOCS3 Primary Antibody for WB - ABIN493472
Alexander, Hilton: The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. in Annual review of immunology 2004
Show all 5 references for ABIN493472
Human Polyclonal SOCS3 Primary Antibody for IF (p), IHC (p) - ABIN670416
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
Show all 4 references for ABIN670416
Human Monoclonal SOCS3 Primary Antibody for WB - ABIN153119
Xiang, Dong, Liu, Wang, Shi, Wei, Hu, Gong: Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-?-induced vascular smooth muscle cells. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013
Human Polyclonal SOCS3 Primary Antibody for IHC, ELISA - ABIN1585262
van de Loo, Veenbergen, van den Brand, Bennink, Blaney-Davidson, Arntz, van Beuningen, van der Kraan, van den Berg: Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function. in Arthritis and rheumatism 2012
Cow (Bovine) Polyclonal SOCS3 Primary Antibody for WB - ABIN374066
Roberts, Robb, Rakar, Hartley, Cluse, Nicola, Metcalf, Hilton, Alexander: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. in Proceedings of the National Academy of Sciences of the United States of America 2001
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (show SFPQ Antibodies) and Socs3a
stat3 (show STAT3 Antibodies)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (show TRPM7 Antibodies) regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Antibodies)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (show MAPK1 Antibodies) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (show SOCS1 Antibodies) and SOCS3 proteins.
None of the clinicopathological parameters were associated with the expressions of FIH-1 (show HIF1AN Antibodies) and SOCS3 at mRNA level.
Micronome revealed miR (show MLXIP Antibodies)-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma.
IGFBP2 (show IGFBP2 Antibodies) and SOCS3 were up-regulated in Kashin-Beck disease chondrocytes and decreased with increasing selenium concentrations. IGFBP2 (show IGFBP2 Antibodies) expressed highest in the middle zone of KBD cartilage, SOCS3 expressed higher in the middle and deep zone. IGFBP2 (show IGFBP2 Antibodies) and SOCS3 may be the biomarkers for KBD diagnosis and evaluating the effect of selenium supplement.
Results show that IFN-alpha (show IFNA Antibodies) antagonizes STAT3 (show STAT3 Antibodies) and SOCS3 signaling triggered by hepatitis C virus (HCV )and that STAT3 (show STAT3 Antibodies) regulation correlates inversely with SOCS3 induction by IFN-alpha (show IFNA Antibodies), which may be important in better understanding the complex interplay between IFN-alpha (show IFNA Antibodies) and signal molecules during HCV infection.
data show that HBV-induced mitochondrial ROS (show ROS1 Antibodies) production represses SOCS3 expression through Snail (show SNAI1 Antibodies)-mediated epigenetic silencing, leading to the sustained activation of IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) pathway and ultimately contributing to hepatocarcinogenesis.
These data thus suggest that overexpression of SOCS1 (show SOCS1 Antibodies) and SOCS3 induced by denguevirus infection leads to impairment of antiviral response through the inhibition of STAT (show STAT1 Antibodies) functionality.
demonstrate an epigenetic mechanism of SOCS3 up-regulation in steroid resistant children with the nephrotic syndrome. The assessment of methylation/unmethylation of SOCS3 promoter might be an early marker for steroid responsiveness in NS patients
Treatment of isolinderalactone increased the protein level of SCOS3, decreased phosphorylation of the STAT3 (show STAT3 Antibodies) and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein (show XIAP Antibodies)
miR (show MLXIP Antibodies)-203 and miR (show MLXIP Antibodies)-221 regulate SOCS1 (show SOCS1 Antibodies) and SOCS3 in essential thrombocythemia
Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer. (Review)
SOCS3 is an important negative regulator of insulin (show INS Antibodies) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (show IL10 Antibodies) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Results identify unrecognized functions of Yes-associated protein (YAP (show YAP1 Antibodies)) in preventing reactive astrogliosis and reveal a pathway of YAP (show YAP1 Antibodies)- suppressor of cytokine signaling 3 (SOCS (show CISH Antibodies)) for the negatively control of neuroinflammation.
SOCS3 serves as an immune modulator interfering with T cells and B cells, and SOCS3 may act as a predictive marker for immune modulation of mesenchymal stromal cells.
Signal transducer and activator of transcription 3 (show STAT3 Antibodies) and suppressor of cytokine signaling 3 play important, yet unexpected, roles in NG2 (show Vcan Antibodies) cell proliferation and differentiation after spinal cord injury.
The results of this study showed that the role of SOCS3 in mediating pregnancy-induced metabolic adaptations.
Concentration of SOCS-3 protein and coimmunoprecipitation of SOCS-3 protein with both the IR-beta subunit (show POLG Antibodies) as well as IRS-1 (show IRS1 Antibodies) was found to be decreased by 4-HIL
CCR5 (show CCR5 Antibodies) blockade suppresses B16 melanoma growth by inhibiting of IL-6 (show IL6 Antibodies)-Stat3 (show STAT3 Antibodies) signaling pathway via upregulation of SOCS3.
AHR (show AHR Antibodies) plays protective roles against high-fat diet-induced hepatic steatosis and the subsequent lipotoxicity via direct transcriptional regulation of Socs3 gene expression.
The liver regenerative effects of HCM appear to be mediated by persistent and uninhibited expression of STAT3 (show STAT3 Antibodies) in the liver, which results from decreased expression of SOCS3
SOCS3 gene expression attenuates contact hypersensitivity by suppressing MMP12 (show MMP12 Antibodies) production.
These results suggest that neuronal and glial cell SOCS3 limits pathological retinal angiogenesis by suppressing VEGF signaling.
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3