Optimal working dilution should be determined by the investigator.
For Research Use only
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Do not freeze.
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: "Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion." in: Endocrine-related cancer, Vol. 14, Issue 4, pp. 1007-19, 2007 (PubMed).
socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, atod4, cis3, cish3, socs-3, ssi-3, ssi3, SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, Cis3, EF-10, Ef10, Ssi3, Socs-3, Ssi-3, suppressor of cytokine signaling 3a, suppressor of cytokine signaling 3 S homeolog, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3 L homeolog, socs3a, socs3.S, socs3, socs3.L, SOCS3, Socs3
SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.