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SOCS3 antibody (Suppressor of Cytokine Signaling 3) Primary Antibody

SOCS3 Reactivity: Human WB Host: Mouse Monoclonal SO1 unconjugated
Pubmed (1)
Catalog No. ABIN94467
$455.40
Plus shipping costs $45.00
0.1 mg
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Delivery in 5 to 7 Business Days
  • Target
    SOCS3
    Reactivity
    Human
    • 67
    • 38
    • 28
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Host
    Mouse
    • 60
    • 21
    • 7
    Clonality
    Monoclonal
    Conjugate
    This SOCS3 antibody is un-conjugated
    • 49
    • 14
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Application
    Western Blotting (WB)
    • 65
    • 39
    • 25
    • 10
    • 10
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Specificity
    The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.
    Cross-Reactivity (Details)
    Human
    Purification
    Purified by protein-A affinity chromatography
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Full-length SOCS3 protein.
    Clone
    SO1
    Isotype
    IgG2b
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: "Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion." in: Endocrine-related cancer, Vol. 14, Issue 4, pp. 1007-19, 2007 (PubMed).

  • Target
    SOCS3
    Alternative Name
    SOCS3 (SOCS3 Antibody Abstract)
    Synonyms
    socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, atod4, cis3, cish3, socs-3, ssi-3, ssi3, SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, Cis3, EF-10, Ef10, Ssi3, Socs-3, Ssi-3, suppressor of cytokine signaling 3a, suppressor of cytokine signaling 3 S homeolog, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3 L homeolog, socs3a, socs3.S, socs3, socs3.L, SOCS3, Socs3
    Background
    SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.
    Pathways
    JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
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