SOCS3 antibody (Suppressor of Cytokine Signaling 3)

Details for Product anti-SOCS3 Antibody No. ABIN94467
Antigen
Reactivity
Human
134
61
45
4
4
4
4
3
1
1
1
1
Host
Mouse
88
68
7
Clonality (Clone)
Monoclonal ()
Conjugate
This SOCS3 antibody is un-conjugated
14
7
3
2
2
2
2
2
2
1
1
1
Application
Western Blotting (WB)
135
64
54
33
25
20
7
6
4
3
2
1
1
1
Options
Immunogen Full-length SOCS3 protein.
Clone SO1
Isotype IgG2b
Specificity The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.
Cross-Reactivity (Details) Human
Purification Purified by protein-A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Antigen
Alternative Name SOCS3 (SOCS3 Antibody Abstract)
Background SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.
Pathways JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Supplier Images
Image no. 1 for anti-Suppressor of Cytokine Signaling 3 (SOCS3) antibody (ABIN94467) Western Blotting analysis (reducing conditions) of whole cell lysate of HeLa human ce...
Product cited in: Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: "Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion." in: Endocrine-related cancer, Vol. 14, Issue 4, pp. 1007-19, 2007 (PubMed).