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anti-Human MAP3K12 Antibodies:
anti-Rat (Rattus) MAP3K12 Antibodies:
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Human Polyclonal MAP3K12 Primary Antibody for ELISA, WB - ABIN4332642
Douziech, Laberge, Grondin, Daigle, Blouin: Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999
Show all 6 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody for IHC (p), WB - ABIN391319
Itoh, Wang, Ito, Reddy, Itoh: SP3 acts as a positive regulator on the core promoter of human ZPK gene. in Biochemical and biophysical research communications 2003
Show all 7 Pubmed References
Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (fro) - ABIN4332644
Welsbie, Mitchell, Jaskula-Ranga, Sluch, Yang, Kim, Buehler, Patel, Martin, Zhang, Ge, Duan, Fuller, Kim, Hamed, Chamling, Lei, Fraser, Ronai, Berlinicke, Zack: Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. in Neuron 2017
Human Polyclonal MAP3K12 Primary Antibody for IHC, IHC (p) - ABIN4332643
Itoh, Horiuchi, Ikeda, Xu, Bannerman, Pleasure, Penninger, Tournier, Itoh: ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
LZK (show MAP3K13 Antibodies) cooperates with DLK (show DAPK3 Antibodies) to promote retinal ganglion cell death in response to axon injury.
REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase
miR (show MLXIP Antibodies)-130a inhibited the JNK (show MAPK8 Antibodies) pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function.
Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration.
these findings indicate that DLK (show DAPK3 Antibodies) participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins.
The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK (show DAPK3 Antibodies) expression and the clinical course of the disease.
the DLK (show DAPK3 Antibodies)-ERK (show EPHB2 Antibodies) signaling pathway may act as a regulator of the interaction that occurs between Hsp27 (show HSPB1 Antibodies) and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function
for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity
ZIPK (show DAPK3 Antibodies) is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity.
DLK (show DAPK3 Antibodies) is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification
These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration.
Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function.
the prevention of the nuclear localization of DLK (show DAPK3 Antibodies) as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus
Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (show DAPK3 Antibodies) does not appear to have a critical function in axonal degeneration; function appears restricted to soma
This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (show MAP2K4 Antibodies)-dependent mechanism in axotomy-induced motoneuron death in neonates
DLK (show DAPK3 Antibodies)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.
Abundance of DLK (show DAPK3 Antibodies) in turn controlled the levels of downstream JNK (show MAPK8 Antibodies) signaling and apoptosis.
DLK (show DAPK3 Antibodies) is required for RGC JNK (show MAPK8 Antibodies) activation and cell death in a rodent model of optic neuropathy
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK (show DAPK3 Antibodies) is an essential upstream mediator of both of these divergent outcomes in the same cell type.
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
, dual leucine zipper bearing kinase
, dual leucine zipper kinase DLK
, leucine zipper protein kinase
, mixed lineage kinase
, protein kinase MUK
, Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase)
, Zipper (leucine) protein kinase
, dual leucine zipper kinase
, leucine-zipper protein kinase
, mitogen-activated protein kinase kinase kinase 12
, mitogen activated protein kinase kinase kinase 12
, zipper (leucine) protein kinase
, mitogen activated protein kinase kinase kinase 12 type A
, mitogen activated protein kinase kinase kinase 12 type B
, mitogen-activated protein kinase kinase kinase 12 L homeolog