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Browse our RALGDS Proteins (RALGDS)

Full name:
Ral Guanine Nucleotide Dissociation Stimulator Proteins (RALGDS)
On are 5 Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Proteins from 3 different suppliers available. Additionally we are shipping RALGDS Antibodies (36) and RALGDS Kits (3) and many more products for this protein. A total of 53 RALGDS products are currently listed.
Gnds, mKIAA1308, RALGDS, RalGEF, Rgds, RGF
list all proteins Gene Name GeneID UniProt
RALGDS 5900 Q12967
RALGDS 19730 Q03385
Rat RALGDS RALGDS 29622 Q03386

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RALGDS Proteins (RALGDS) by Origin

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More Proteins for RALGDS Interaction Partners

Human Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) interaction partners

  1. Investigated is the role that electrostatic field differences caused by the charge reversal mutation Rap1A K31E play in determining the binding specificity of RalGDS to Rap1A versus Ras.

  2. Studies provide models for Ras in association with Raf (show RAF1 Proteins) kinase, RalGDS and PI3Kalpha (show PIK3CA Proteins) and PI3Kgamma (show PIK3CG Proteins).

  3. involved in regulation of choline kinase activity by Ras proteins

  4. identified Ral-GDS as a beta-arrestin-binding protein by yeast two-hybrid screening and co-immunoprecipitation from human polymorphonuclear neutrophilic leukocytes

  5. RALGDS has a role in attenuating p53 (show TP53 Proteins)-independent DNA damage G2 checkpoint

  6. Merlin (show NF2 Proteins) can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals.

  7. These data extend understanding of the functional roles of the Ral (show rala Proteins) pathway and begin to identify signaling pathways relevant for organ-specific metastasis.

  8. results of screening suggest that RALGDS is not mutationally altered in cutaneous melanoma

  9. overexpression of RalGDS promotes exocytosis of Weibel-Palade bodies from endothelial cells

  10. RalGDS and RalA (show rala Proteins) act downstream of Rheb (show RHEB Proteins) and that RalA (show rala Proteins) activation is a crucial step in nutrient-induced mTORC1 activation

Mouse (Murine) Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) interaction partners

  1. Data implicate RalGDS-mediated induction of autophagy and exocyst function as a critical feature of load-induced cardiac hypertrophy.

  2. constitutive RalGEF activation had a major impact on several malignant phenotypes, particularly anchorage-independent growth, indicating that this often overlooked pathway should be more carefully evaluated as a possible therapeutic target.

  3. we investigated the activation of RalGDS, one of the Ras effector proteins with guanine-nucleotide exchange factor (show ARHGEF12 Proteins) activity for Ral (show rala Proteins).

  4. Results identify RalGDS as a key component in Ras-dependent carcinogenesis in vivo.

RALGDS Protein Profile

Protein Summary

Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.

Alternative names and synonyms associated with RALGDS

  • ral guanine nucleotide dissociation stimulator (RALGDS)
  • ral guanine nucleotide dissociation stimulator (ralgds)
  • ral guanine nucleotide dissociation stimulator (Ralgds)
  • Gnds protein
  • mKIAA1308 protein
  • RALGDS protein
  • RalGEF protein
  • Rgds protein
  • RGF protein

Protein level used designations for RALGDS

ral guanine nucleotide dissociation stimulator , ral guanine nucleotide exchange factor , ralGEF

427758 Gallus gallus
464824 Pan troglodytes
714436 Macaca mulatta
783943 Bos taurus
100017777 Monodelphis domestica
100135084 Xenopus (Silurana) tropicalis
100543539 Meleagris gallopavo
100589231 Nomascus leucogenys
5900 Homo sapiens
19730 Mus musculus
29622 Rattus norvegicus
480686 Canis lupus familiaris
513723 Bos taurus
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