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Investigated is the role that electrostatic field differences caused by the charge reversal mutation Rap1A K31E play in determining the binding specificity of RalGDS to Rap1A versus Ras.
Studies provide models for Ras in association with Raf (show RAF1 Proteins) kinase, RalGDS and PI3Kalpha (show PIK3CA Proteins) and PI3Kgamma (show PIK3CG Proteins).
involved in regulation of choline kinase activity by Ras proteins
identified Ral-GDS as a beta-arrestin-binding protein by yeast two-hybrid screening and co-immunoprecipitation from human polymorphonuclear neutrophilic leukocytes
RALGDS has a role in attenuating p53 (show TP53 Proteins)-independent DNA damage G2 checkpoint
Merlin (show NF2 Proteins) can function as a tumor suppressor by inhibiting the RalGDS-mediated oncogenic signals.
These data extend understanding of the functional roles of the Ral (show rala Proteins) pathway and begin to identify signaling pathways relevant for organ-specific metastasis.
results of screening suggest that RALGDS is not mutationally altered in cutaneous melanoma
overexpression of RalGDS promotes exocytosis of Weibel-Palade bodies from endothelial cells
RalGDS and RalA (show rala Proteins) act downstream of Rheb (show RHEB Proteins) and that RalA (show rala Proteins) activation is a crucial step in nutrient-induced mTORC1 activation
Data implicate RalGDS-mediated induction of autophagy and exocyst function as a critical feature of load-induced cardiac hypertrophy.
constitutive RalGEF activation had a major impact on several malignant phenotypes, particularly anchorage-independent growth, indicating that this often overlooked pathway should be more carefully evaluated as a possible therapeutic target.
we investigated the activation of RalGDS, one of the Ras effector proteins with guanine-nucleotide exchange factor (show ARHGEF12 Proteins) activity for Ral (show rala Proteins).
Results identify RalGDS as a key component in Ras-dependent carcinogenesis in vivo.
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.
ral guanine nucleotide dissociation stimulator
, ral guanine nucleotide exchange factor