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Browse our TNFRSF11A Proteins (TNFRSF11A)

Full name:
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator Proteins (TNFRSF11A)
On are 23 Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) Proteins from 9 different suppliers available. Additionally we are shipping TNFRSF11A Antibodies (126) and TNFRSF11A Kits (29) and many more products for this protein. A total of 185 TNFRSF11A products are currently listed.
list all proteins Gene Name GeneID UniProt
TNFRSF11A 498206  
TNFRSF11A 21934 O35305
TNFRSF11A 8792 Q9Y6Q6

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TNFRSF11A Proteins (TNFRSF11A) by Origin

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Top referenced TNFRSF11A Proteins

  1. Human TNFRSF11A Protein expressed in Human Cells - ABIN2006717 : Galibert, Tometsko, Anderson, Cosman, Dougall: The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. in The Journal of biological chemistry 1999 (PubMed)

More Proteins for TNFRSF11A Interaction Partners

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) interaction partners

  1. present study shows that ginsenoside Rg3 protects against LPS (show TLR4 Proteins)-induced acute lung injury through inactivating the NF-kappaB (show NFKB1 Proteins) signaling

  2. In palmatine-treated mice, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) levels were significantly reduced by palmatine addition.

  3. Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL (show TNFSF11 Proteins)/RANK affinity and osteoclastogenic capacity.

  4. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (show NFKB1 Proteins)/receptor activator NF-kappaB (show NFKB1 Proteins) ligand, and NF-kappaB (show NFKB1 Proteins) signaling pathways.

  5. We also show that R-spondin1 (show RSPO1 Proteins) is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 Proteins) response and mammary cell expansion

  6. findings have uncovered a tumorigenic role for RANKL (show TNFSF11 Proteins)/RANK in the salivary gland and suggest that targeting this pathway may represent a novel therapeutic intervention approach in the prevention and/or treatment of this understudied head and neck cancer

  7. results indicate that the RANK IVVY motif cooperates with the TRAF (show TRAF1 Proteins)-binding motifs to promote osteoclastogenesis, which provides novel insights into the molecular mechanism of RANK signaling in osteoclastogenesis.

  8. findings suggest CCN2 (show CTGF Proteins) as a candidate of the fourth factor in the RANK/RANKL/OPG (show TNFSF11 Proteins) system for osteoclastogenesis, which regulates OPG (show TNFSF11 Proteins) and RANK via direct interaction

  9. Recapitulating the W434X mutation by transcription activator-like effector nuclease (show DCLRE1C Proteins)-mediated targeted disruption of Tnfrsf11a within the region homologous to W434X in the macrophage-like cell line RAW264.7 impaired formation of osteoclast-like cells.

  10. silencing angiopoietin-like protein 4 (show ANGPTL4 Proteins) protects against LPS (show TLR4 Proteins)-induced acute lung injury via regulating SIRT1 (show SIRT1 Proteins)/NF-kB signaling pathway

Human Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) interaction partners

  1. Twenty-one single-nucleotide polymorphisms (SNPs) of TNFSF11, TNFRSF11A, and TNFRSF11B were genotyped. This study suggests that TNFRSF11B but not TNFSF11 and TNFRSF11A genetic polymorphisms are associated with Type 2 Diabetes Mellitus in Southern Han Chinese women.

  2. the OPG/RANKL (show TNFSF11 Proteins)/RANK system might be directly influenced by genetic variants of NOTCH1 (show NOTCH1 Proteins) in aortic valve calcification.

  3. Postmenopausal women with Rheumatoid Arthritis, carrying either the RANKL (show TNFSF11 Proteins)-290T allele or possessing the RANK 575CC genotype were more likely to develop osteoporosis.

  4. The RANK/RANKL (show TNFSF11 Proteins) system induces chemoresistance.

  5. RANK and CCR6 (show CCR6 Proteins) expressed on monocytes may be novel targets for the regulation of bone resorption in rheumatoid arthritis and osteoporosis.

  6. Results demonstrated that the type of inflammatory infiltrate present in periradicular cysts appears to influence the expression of RANK, RANKL (show TNFSF11 Proteins), and osteoprotegerin (show TNFRSF11B Proteins)

  7. Study showed that endogenous RANK expression changes might influence prostate cancer cell behavior since reduced RANK expression resulted in significantly increased PC-3 (show PCSK1 Proteins) cell proliferation and adhesion.

  8. expression of OPG (show TNFRSF11B Proteins), RANK and RANKL (show TNFSF11 Proteins) genes exert a crucial role in the progression of avascular necrosis

  9. Src (show SRC Proteins) expression showed a significantly positive linear relationship with RANK, suggesting a potential mechanism of the RANKL (show TNFSF11 Proteins)-RANK axis in regulating breast cancer cell differentiation and antiapoptosis.

  10. high level of mRANKL/RANK expression in cervical cancer lesions plays an important role in the rapid growth of cervical cancer cells possibly through strengthening the dialogue between cervical cancer cells and regulation of IL-8 (show IL8 Proteins) secretion

TNFRSF11A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Alternative names and synonyms associated with TNFRSF11A

  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (Tnfrsf11a)
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A)
  • tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a)
  • CD265 protein
  • FEO protein
  • LOH18CR1 protein
  • Ly109 protein
  • mRANK protein
  • ODFR protein
  • OFE protein
  • OPTB7 protein
  • OSTS protein
  • PDB2 protein
  • Rank protein
  • RGD1563614 protein
  • TNFRSF11A protein
  • TRANCE-R protein
  • TRANCER protein

Protein level used designations for TNFRSF11A

tumor necrosis factor receptor superfamily member 11A , tumor necrosis factor receptor superfamily, member 11a, NFKB activator , receptor activator of nuclear factor-kappa B , tumor necrosis factor receptor superfamily member 11A-like , osteoclast differentiation factor receptor , receptor activator of NF-KB , receptor activator of NF-kappaB , loss of heterozygosity, 18, chromosomal region 1

498206 Rattus norvegicus
468560 Pan troglodytes
483957 Canis lupus familiaris
530884 Bos taurus
769909 Gallus gallus
100358260 Oryctolagus cuniculus
100433235 Pongo abelii
21934 Mus musculus
8792 Homo sapiens
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