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Browse our TNFRSF11A Proteins (TNFRSF11A)

Full name:
Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator Proteins (TNFRSF11A)
On www.antibodies-online.com are 21 Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) Proteins from 8 different suppliers available. Additionally we are shipping TNFRSF11A Antibodies (115) and TNFRSF11A Kits (26) and many more products for this protein. A total of 169 TNFRSF11A products are currently listed.
Synonyms:
CD265, FEO, LOH18CR1, Ly109, mRANK, ODFR, OFE, OPTB7, OSTS, PDB2, Rank, RGD1563614, TNFRSF11A, TRANCE-R, TRANCER
list all proteins Gene Name GeneID UniProt
TNFRSF11A 498206  
TNFRSF11A 21934 O35305
TNFRSF11A 8792 Q9Y6Q6

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TNFRSF11A Proteins (TNFRSF11A) by Origin

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Top referenced TNFRSF11A Proteins

  1. Human TNFRSF11A Protein expressed in Human Cells - ABIN2006717 : Galibert, Tometsko, Anderson, Cosman, Dougall: The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. in The Journal of biological chemistry 1999 (PubMed)

More Proteins for TNFRSF11A Interaction Partners

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) interaction partners

  1. In palmatine-treated mice, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL (show TNFSF11 Proteins) and OPG (show TNFSF11 Proteins) levels were significantly reduced by palmatine addition.

  2. Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL (show TNFSF11 Proteins)/RANK affinity and osteoclastogenic capacity.

  3. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (show NFKB1 Proteins)/receptor activator NF-kappaB (show NFKB1 Proteins) ligand, and NF-kappaB (show NFKB1 Proteins) signaling pathways.

  4. We also show that R-spondin1 (show RSPO1 Proteins) is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 Proteins) response and mammary cell expansion

  5. findings have uncovered a tumorigenic role for RANKL (show TNFSF11 Proteins)/RANK in the salivary gland and suggest that targeting this pathway may represent a novel therapeutic intervention approach in the prevention and/or treatment of this understudied head and neck cancer

  6. results indicate that the RANK IVVY motif cooperates with the TRAF (show TRAF1 Proteins)-binding motifs to promote osteoclastogenesis, which provides novel insights into the molecular mechanism of RANK signaling in osteoclastogenesis.

  7. findings suggest CCN2 (show CTGF Proteins) as a candidate of the fourth factor in the RANK/RANKL/OPG (show TNFSF11 Proteins) system for osteoclastogenesis, which regulates OPG (show TNFSF11 Proteins) and RANK via direct interaction

  8. Recapitulating the W434X mutation by transcription activator-like effector nuclease (show DCLRE1C Proteins)-mediated targeted disruption of Tnfrsf11a within the region homologous to W434X in the macrophage-like cell line RAW264.7 impaired formation of osteoclast-like cells.

  9. silencing angiopoietin-like protein 4 (show ANGPTL4 Proteins) protects against LPS (show TLR4 Proteins)-induced acute lung injury via regulating SIRT1 (show SIRT1 Proteins)/NF-kB signaling pathway

  10. silencing of miR (show MLXIP Proteins)-503 using a specific antagomir in ovariectomy (OVX) mice increased RANK protein expression, promoted bone resorption

Human Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) interaction partners

  1. expression of OPG (show TNFRSF11B Proteins), RANK and RANKL (show TNFSF11 Proteins) genes exert a crucial role in the progression of avascular necrosis

  2. Src (show SRC Proteins) expression showed a significantly positive linear relationship with RANK, suggesting a potential mechanism of the RANKL (show TNFSF11 Proteins)-RANK axis in regulating breast cancer cell differentiation and antiapoptosis.

  3. high level of mRANKL/RANK expression in cervical cancer lesions plays an important role in the rapid growth of cervical cancer cells possibly through strengthening the dialogue between cervical cancer cells and regulation of IL-8 (show IL8 Proteins) secretion

  4. we could not identify any association between external apical root resorption and two SNPs, rs1805034 from TNFRSF11A (encoding RANK) and rs3102735 from TNFRSF11B (show TNFRSF11B Proteins) (encoding OPG (show TNFRSF11B Proteins)).

  5. Results suggest that Cbl-b improves the prognosis of RANK-expressing breast cancer patients by inhibiting RANKL (show TNFSF11 Proteins)-induced breast cancer cell migration and metastasis.

  6. Based on our findings, the functional SNP RANK rs1805034 T>C may be an indicator for individual susceptibility to GCA (show NPR1 Proteins).

  7. this study is the first to identify RANK overexpression as a novel esophageal cancer marker in both Kazakh and Han ethnic esophageal squamous cell carcinoma patients.

  8. RANK/OPG (show TNFRSF11B Proteins) ratio of expression in primary ccRCC is associated with BM.

  9. Three single nucleotide polymorphisms of TNFRSF11A (rs4500848, rs6567270 and rs1805034) are associated with Age at menarche and Age at natural menopause in Chinese women.

  10. results indicate that the RANK IVVY motif cooperates with the TRAF (show TRAF1 Proteins)-binding motifs to promote osteoclastogenesis, which provides novel insights into the molecular mechanism of RANK signaling in osteoclastogenesis.

TNFRSF11A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Alternative names and synonyms associated with TNFRSF11A

  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (Tnfrsf11a)
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A)
  • tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a)
  • CD265 protein
  • FEO protein
  • LOH18CR1 protein
  • Ly109 protein
  • mRANK protein
  • ODFR protein
  • OFE protein
  • OPTB7 protein
  • OSTS protein
  • PDB2 protein
  • Rank protein
  • RGD1563614 protein
  • TNFRSF11A protein
  • TRANCE-R protein
  • TRANCER protein

Protein level used designations for TNFRSF11A

tumor necrosis factor receptor superfamily member 11A , tumor necrosis factor receptor superfamily, member 11a, NFKB activator , receptor activator of nuclear factor-kappa B , tumor necrosis factor receptor superfamily member 11A-like , osteoclast differentiation factor receptor , receptor activator of NF-KB , receptor activator of NF-kappaB , loss of heterozygosity, 18, chromosomal region 1

GENE ID SPECIES
498206 Rattus norvegicus
468560 Pan troglodytes
483957 Canis lupus familiaris
530884 Bos taurus
769909 Gallus gallus
100358260 Oryctolagus cuniculus
100433235 Pongo abelii
21934 Mus musculus
8792 Homo sapiens
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