Browse our anti-APH1A (APH1A) Antibodies

Full name:
anti-Anterior Pharynx Defective 1 Homolog A (C. Elegans) Antibodies (APH1A)
On are 110 Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) Antibodies from 22 different suppliers available. Additionally we are shipping APH1A Kits (11) and and many more products for this protein. A total of 130 APH1A products are currently listed.
6530402N02Rik, APH-1, APH-1A, Aph1, CGI-78, RGD1311546
list all antibodies Gene Name GeneID UniProt
APH1A 103979  
APH1A 51107 Q96BI3
APH1A 365872  

Show all species

Show all synonyms

Most Popular Reactivities for anti-APH1A (APH1A) Antibodies

Select your species and application

anti-Mouse (Murine) APH1A Antibodies:

anti-Human APH1A Antibodies:

anti-Rat (Rattus) APH1A Antibodies:

All available anti-APH1A Antibodies

Go to our pre-filtered search.

Top referenced anti-APH1A Antibodies

  1. Human Polyclonal APH1A Primary Antibody for EIA, IHC (p) - ABIN358830 : Kimberly, LaVoie, Ostaszewski, Ye, Wolfe, Selkoe: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 5 references for 358830

  2. Human Polyclonal APH1A Primary Antibody for IHC (p), WB - ABIN390272 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 5 references for 390272

  3. Human Polyclonal APH1A Primary Antibody for ChIP, ICC - ABIN261469 : Gu, Chen, Sanjo, Kawarai, Hasegawa, Duthie, Li, Ruan, Luthra, Mount, Tandon, Fraser, St George-Hyslop: APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 261469

  4. Human Polyclonal APH1A Primary Antibody for ELISA, WB - ABIN253299 : Spasic, Raemaekers, Dillen, Declerck, Baert, Serneels, Füllekrug, Annaert: Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway. in The Journal of cell biology 2007 (PubMed)

More Antibodies against APH1A Interaction Partners

Mouse (Murine) Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) interaction partners

  1. Prostaglandin I2 accumulation in neuronal cells activates PKA/CREB (show CREB1 Antibodies) and JNK/c-Jun signaling pathways by phosphorylation, which results in APH-1alpha/1beta expression.

  2. Thus, Leda-1/Pianp (show C12orf53 Antibodies) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (show ADAM10 Antibodies)/17 and intramembrane protease gamma-secretase.

  3. Abeta (show APP Antibodies) oligomers in the cerebrospinal fluid (CSF (show CSF2 Antibodies)) further promoted the expression of APH-1alpha/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP (show APP Antibodies) and Abeta (show APP Antibodies) deposition during AD progression

  4. Upregulation of PS1 (show PSEN1 Antibodies)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.

  5. ficiency of beta-arrestin1 (show ARRB1 Antibodies) or inhibition of binding of beta-arrestin1 (show ARRB1 Antibodies) with APH-1 by small peptides reduced Abeta (show APP Antibodies) production without affecting Notch (show NOTCH1 Antibodies) processing

  6. Pen-2 (show PSENEN Antibodies), as well as nicastrin (show NCSTN Antibodies) and Aph-1alpha, is dispensable for presenilin endoproteolysis

  7. We propose a model that identifies critical TMDs of Aph-1 for associations with Nct (show NCSTN Antibodies) and PS for the stepwise assembly of gamma-secretase components.

  8. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates

  9. presenilin 1 (PS1 (show PSEN1 Antibodies))-derived fragments, mature nicastrin (show NCSTN Antibodies), APH-1, and PEN-2 (show PSENEN Antibodies), associate with cholesterol-rich detergent insoluble membrane (DIM) domains of non-neuronal cells and neurons

  10. Our findings establish that APH-1a is the major mammalian APH-1 homolog present in presenilin-dependent gamma-secretase complexes during embryogenesis.

Human Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A) interaction partners

  1. Using purified PSEN1 (show PSEN1 Antibodies)/Aph1A gamma-secretase and the APPC99-3XFLAG substrate, authors show that substrate shortening progressively destabilizes the consecutive enzyme-substrate complexes that characterize the sequential gamma-secretase processing of APP (show APP Antibodies); present a unifying model for how PSEN (show PSEN1 Antibodies) or APP (show APP Antibodies) mutations enhance amyloidogenic Abeta (show APP Antibodies) production, suggests that environmental factors may increase Alzheimer's Disease risk.

  2. Data show that presenilin 1 (PS1 (show PSEN1 Antibodies))/anterior-pharynx-defective protein 1 (Aph1b (show aph1b Antibodies)), presenilin 2 (PS2 (show PSEN2 Antibodies))/Aph1aL, PS2 (show PSEN2 Antibodies)/Aph1aS and PS2 (show PSEN2 Antibodies)/anterior pharynx defective 1 homolog B (Aph1b (show aph1b Antibodies)) gamma-secretase produced amyloid beta peptide (Abeta (show APP Antibodies)) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  3. Data show that presenilin 1 (PS1 (show PSEN1 Antibodies))-containing gamma-secretase complexes were targeted to the plasma membrane, whereas presenilin 2 (PS2 (show PSEN2 Antibodies))-containing ones were addressed to the trans-Golgi network, to recycling endosomes.

  4. No statistically significant difference was detected either in APOE (show APOE Antibodies) or APH-1a polymorphisms, not suggesting a strong susceptibility to the development of Alzheimer disease.

  5. analysis of how the conformation of presenilin, Pen-2 (show PSENEN Antibodies), Aph-1, and nicastrin (show NCSTN Antibodies) affect the function and mechanism of gamma-secretase

  6. We demonstrate that extending the transmembrane domain of the amyloid precursor protein (show APP Antibodies)-derived C99 substrate in proximity to the cytosolic face strongly influences gamma-secretase cleavage specificity.

  7. The -980C/G polymorphism in APH-1A promoter confers risk of Alzheimer's disease

  8. Coexpression of wild-type or S-palmitoylation-deficient APH1aL and nicastrin (show NCSTN Antibodies) leads to marked stabilization of transgenic presenilin 1 (show PSEN1 Antibodies) in the brains of double-transgenic mice.

  9. Endogenous Aph-1a and its proteolytic fragment have unique properties for cleavage control that may have implications for gamma-secretase regulation and intracellular distribution.

  10. Co-overexpression of presenilin-1 (show PSEN1 Antibodies) or APH-1 abrogated gamma-secretase inhibition probably through prevention of the incorporation of CRB2 (show CRB2 Antibodies) into the gamma-secretase complex

APH1A Antigen Profile

Antigen Summary

This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

Alternative names and synonyms associated with APH1A

  • anterior pharynx defective 1 homolog A (C. elegans) (APH1A) antibody
  • APH1A gamma secretase subunit (aph1a) antibody
  • anterior pharynx defective 1 homolog A (LOC100342209) antibody
  • N-acylaminoacyl-peptide hydrolase (APEH) antibody
  • N-acylaminoacyl-peptide hydrolase (LOC100219182) antibody
  • alphaprotein 1 (Alph1) antibody
  • anterior pharynx defective 1a homolog (C. elegans) (Aph1a) antibody
  • APH1A gamma secretase subunit (APH1A) antibody
  • APH1A gamma secretase subunit (Aph1a) antibody
  • 6530402N02Rik antibody
  • APH-1 antibody
  • APH-1A antibody
  • Aph1 antibody
  • CGI-78 antibody
  • RGD1311546 antibody

Protein level used designations for APH1A

gamma-secretase subunit APH-1A , anterior pharynx defective 1 homolog A , anterior pharynx defective 1 homolog A (C. elegans) , N-acylaminoacyl-peptide hydrolase , acylamino-acid-releasing enzyme-like , aph-1alpha , presenilin-stabilization factor , anterior pharynx defective 1a homolog

457270 Pan troglodytes
595044 Xenopus laevis
706483 Macaca mulatta
769986 Gallus gallus
100342209 Oryctolagus cuniculus
460376 Pan troglodytes
705948 Macaca mulatta
100053100 Equus caballus
100219182 Taeniopygia guttata
100354109 Oryctolagus cuniculus
100396609 Callithrix jacchus
100435231 Pongo abelii
100475477 Ailuropoda melanoleuca
100582434 Nomascus leucogenys
103979 Mus musculus
100154978 Sus scrofa
539247 Bos taurus
226548 Mus musculus
51107 Homo sapiens
365872 Rattus norvegicus
483181 Canis lupus familiaris
Selected quality suppliers for anti-APH1A (APH1A) Antibodies
Did you look for something else?