APH1A Products
(Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
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This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011].
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Featured APH1A Categories
APH1A Antibodies
High quality antibodies with extensive validation data.
APH1A ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended APH1A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN706016
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN190762
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN390272
Quantity
400 μL
Datasheet
Datasheet
Recommended APH1A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964897
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964898
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN455171
Quantity
96 tests
Datasheet
Datasheet
Recommended APH1A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121856
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3104883
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3125308
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our APH1A products
: "Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria." in: The American journal of pathology, Vol. 175, Issue 5, pp. 1810-6, (2009) (PubMed).: "Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway." in: The Journal of cell biology, Vol. 176, Issue 5, pp. 629-40, (2007) (PubMed).
: "APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 1, pp. 192-8, (2005) (PubMed).
: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "The role of presenilin cofactors in the gamma-secretase complex." in: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
: "APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7374-80, (2003) (PubMed).
: "APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 775-9, (2002) (PubMed).
Synonyms and alternative names related to APH1A
aph-1 homolog A, gamma-secretase subunit (APH1A), aph-1 homolog A, gamma secretase subunit L homeolog (aph1a.L), aph-1 homolog A, gamma secretase subunit (Aph1a), anterior pharynx defective 1 homolog A (C. elegans) (APH1A), aph1 homolog A, gamma secretase subunit (Aph1a), acylamino-acid-releasing enzyme-like (LOC100219182), 6530402N02Rik, APH-1, APH-1A, APH-1a, CGI-78, RGD1311546Protein level used designations for APH1A
- anterior pharynx defective 1 homolog A
- aph-1alpha
- gamma-secretase subunit APH-1A
- presenilin-stabilization factor
- anterior pharynx defective 1a homolog
- N-acylaminoacyl-peptide hydrolase
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