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APH1A antibody (N-Term)
APH1A
Reactivity: Mouse
WB
Host: Rabbit
Polyclonal
RB39321
unconjugated
Product Details anti-APH1A Antibody
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Target
See all APH1A Antibodies
APH1A
(Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
Binding Specificity
All epitopes for APH1A antibodies
AA 41-70, N-Term
Reactivity
All reactivities for APH1A antibodies
Mouse
Host
All hosts for APH1A antibodies
Rabbit
Clonality
All clonalities for APH1A antibodies
Polyclonal
Conjugate
All conjugates for APH1A antibodies
This APH1A antibody is un-conjugated
Application
All applications for APH1A antibodies
Western Blotting (WB)
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This APH1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human APH1A.
Clone
RB39321
Isotype
Ig Fraction
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Discover our top product APH1A Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
APH1A Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
Expiry Date
6 months
Target Details for APH1A
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Target
APH1A
(Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
Alternative Name
APH1A (APH1A Products )
Synonyms
6530402N02Rik antibody, APH-1 antibody, APH-1A antibody, CGI-78 antibody, RGD1311546 antibody, APH-1a antibody, aph-1 homolog A, gamma-secretase subunit antibody, aph-1 homolog A, gamma secretase subunit L homeolog antibody, aph-1 homolog A, gamma secretase subunit antibody, anterior pharynx defective 1 homolog A (C. elegans) antibody, aph1 homolog A, gamma secretase subunit antibody, acylamino-acid-releasing enzyme-like antibody, APH1A antibody, aph1a.L antibody, Aph1a antibody, LOC100219182 antibody
Background
APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1, MIM 104311) and nicastrin (APH2, MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP, MIM 104760) and Notch (MIM 190198).
Molecular Weight
28996
Gene ID
51107
NCBI Accession
NP_001071096 , NP_001230700 , NP_001230701 , NP_057106
UniProt
Q96BI3
Pathways
Notch Signaling , Neurotrophin Signaling Pathway
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