Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A) Peptide
RIC8A
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939929
$398.38
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A) Peptide (ABIN939929)
Target
RIC8A
(Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- KLTERVGLYR ERSFPHDVQF FDLRLLFLLT ALRTDVRQQL FQELKGVRLL
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of RIC8 A antibody,
Alternative Names: RIC8A control peptide, RIC8A antibody Blocking Peptide, Anti-RIC8A Blocking Peptide, Resistance To Inhibitors Of Cholinesterase 8 Homolog A Blocking Peptide, MGC104517 Blocking Peptide, MGC131931 Blocking Peptide, MGC148073 Blocking Peptide, MGC148074 Blocking Peptide, RIC8 Blocking Peptide, synembryn Blocking Peptide, RIC8A, RICA-8, RICA 8, RICA-8 Blocking Peptide, RICA 8 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))
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Background
- RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8A also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
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Molecular Weight
- 60 kDa
Target
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