E2F Transcription Factor 7 (E2F7) (N-Term) Peptide
E2F7
Reactivity: Human
Host: Synthetic
BP, WB
Quick Overview for E2F Transcription Factor 7 (E2F7) (N-Term) Peptide (ABIN976085)
Target
E2F7
(E2F Transcription Factor 7 (E2F7))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- MEVNCLTLKD LISPRQTRLD FAIEDAENAQ KENIFVDRSR MTPKTPMKNE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-E2F7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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E2F Transcription Factor 7 (E2F7) peptide
E2F7 Reactivity: Human, Dog, Pig Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- E2F7 (E2F Transcription Factor 7 (E2F7))
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Background
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E2F7 is a atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. E2F7 mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. It directly represses transcription of classical E2F transcription factors such as E2F1. It acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. It plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). It is required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter.
Alias Symbols: E2f7,
Protein Size: 904 -
Molecular Weight
- 99 kDa
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Gene ID
- 52679
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NCBI Accession
- XP_006513945
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UniProt
- Q6S7F2
Target
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