14-3-3 sigma/SFN Protein (AA 1-248)
Quick Overview for 14-3-3 sigma/SFN Protein (AA 1-248) (ABIN935074)
Target
See all 14-3-3 sigma/SFN (SFN) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-248
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Sequence
- MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
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Characteristics
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Purified recombinant Human 14.3.3 sigma protein
Expression System: E.coli
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Stratifin (SFN) (AA 1-248) protein (His tag)
custom-made SFN Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Stratifin (SFN) (AA 1-248) protein (His tag)custom-made SFN Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Stratifin (SFN) (AA 1-248) protein (GST tag)SFN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- 14.3.3 Sigma protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 50 mM NaCl and 10 % glycerol.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
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Alternative Name
- 14.3.3 sigma
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Background
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14-3-3 sigma, also known as Stratifin (SFN), belongs to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: HME1 protein, SFN protein, 14.3.3 sigma, Epithelial cell marker protein 1 protein, stratifin protein, 14-3-3 sigma protein, 14/3/3 sigma protein, YWHAS protein, 14-3-3 sigma, 14/3/3 sigma, 14-3-3 sigma -
Molecular Weight
- 27.7 kDa (248 AA)
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Pathways
- p53 Signaling, Myometrial Relaxation and Contraction
Target
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