CCL3 Protein
Quick Overview for CCL3 Protein (ABIN935631)
Target
See all CCL3 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA
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Characteristics
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Purified recombinant Human MIP1 alpha protein
Expression System: E.coli
Bioactivity: Determined by its ability to chemoattract rat peritoneal macrophages using a concentration of 50.0-100.0 ng/mL. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))
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Alternative Name
- MIP1 alpha
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Background
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Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ, with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and Mouse MIP-1 alpha and MIP-1 beta are active on human and Mouse hematopoietic cells.
Alternative Names: MIP-1 alpha protein, LD78 beta protein, MIP 1 alpha, CCL3 protein, MIP 1 alpha protein, MIP-1 alpha protein, MIP-1 alpha, Macrophage Inflammatory Protein-1 alpha protein, MIP1 alpha -
Molecular Weight
- 7.8 kDa
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Autophagy
Target
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