TNFRSF1A Protein
Quick Overview for TNFRSF1A Protein (ABIN935851)
Target
See all TNFRSF1A ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN
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Characteristics
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Purified recombinant Human TNF Receptor Type I protein
Expression System: E.coli
Bioactivity: Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in Mouse L-929 cells. The ED50 for this effect in the presence of 0.25 ng/mL of recombinant human TNF-alpha, is 0.05 µg/mL. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) (Active) protein (His tag)
TNFRSF1A Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) (Active) protein (His tag)TNFRSF1A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 22-211) protein (His-DYKDDDDK-Strep II Tag)TNFRSF1A Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 31-130) protein (GST tag)TNFRSF1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 1-455) protein (GST tag)TNFRSF1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (Active) protein (Fc Tag)TNFRSF1A Origin: Rat Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) proteinTNFRSF1A Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (Active) protein (His tag)TNFRSF1A Origin: Rat Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (Active) protein (His tag)TNFRSF1A Origin: Mouse Host: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) (AA 30-211) protein (Fc Tag)TNFRSF1A Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
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Alternative Name
- TNF Receptor Type I
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Background
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TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NF kb, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands.
Alternative Names: TNFR60 protein, TNF-R55 protein, TNF Receptor 1 protein, TNF Receptor I protein, CD120a protein, TNFRSF1A protein, p55 protein, TNFAR protein, Soluble Tumor Necrosis Factor type I protein -
Molecular Weight
- 18.3 kDa
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Pathways
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C, Ubiquitin Proteasome Pathway
Target
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