Browse our Lymphocyte-Activation Gene 3 Proteins (LAG3)

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Lymphocyte-Activation Gene 3 Proteins (LAG3)
On are 45 Lymphocyte-Activation Gene 3 (LAG3) Proteins from 12 different suppliers available. Additionally we are shipping Lymphocyte-Activation Gene 3 Antibodies (223) and Lymphocyte-Activation Gene 3 Kits (18) and many more products for this protein. A total of 292 Lymphocyte-Activation Gene 3 products are currently listed.
CD223, LAG-3, Ly66
list all proteins Gene Name GeneID UniProt
LAG3 16768 Q61790
LAG3 3902 P18627
LAG3 297596 Q5BK54

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Lymphocyte-Activation Gene 3 Proteins (LAG3) by Origin

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Top referenced Lymphocyte-Activation Gene 3 Proteins

  1. Rat (Rattus) LAG3 Protein expressed in Human Cells - ABIN2009550 : Baixeras, Huard, Miossec, Jitsukawa, Martin, Hercend, Auffray, Triebel, Piatier-Tonneau: Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. in The Journal of experimental medicine 1992 (PubMed)
    Show all 3 references for 2009550

  2. Human LAG3 Protein expressed in HEK-293 Cells - ABIN2181447 : Triebel, Jitsukawa, Baixeras, Roman-Roman, Genevee, Viegas-Pequignot, Hercend: LAG-3, a novel lymphocyte activation gene closely related to CD4. in The Journal of experimental medicine 1990 (PubMed)
    Show all 2 references for 2181447

More Proteins for Lymphocyte-Activation Gene 3 Interaction Partners

Cow (Bovine) Lymphocyte-Activation Gene 3 (LAG3) interaction partners

Rhesus Monkey Lymphocyte-Activation Gene 3 (LAG3) interaction partners

  1. We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with mycobacterium tuberculosis.

Mouse (Murine) Lymphocyte-Activation Gene 3 (LAG3) interaction partners

  1. thi study shows that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8 (show CD8A Proteins)+ T cell responses

  2. Study suggests that expression of the inhibitory receptors PD-1 (show PDCD1 Proteins) and LAG-3 on CD4 (show CD4 Proteins)(+) T cells and their reduced IL-2 (show IL2 Proteins) production are common characteristic features of Plasmodium infection.

  3. An IL-27 (show IL27 Proteins)/Lag3 axis enhances Foxp3 (show FOXP3 Proteins)+ regulatory T cell-suppressive function and therapeutic efficacy.

  4. LAG3 and PD1 (show PDCD1 Proteins) co-inhibitory molecules have roles in collaborating to limit CD8 (show CD8A Proteins)+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

  5. Poxvirus-Based Active Immunotherapy with PD-1 (show PDCD1 Proteins) and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.

  6. Lymphatic endothelial cells (LECs) serve as an antigen reservoir for CD4 (show CD4 Proteins) T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 (show CD8A Proteins) T-cell tolerance via LAG-3.

  7. LAG-3 expression on Tconv cells makes them more susceptible to Treg based suppression, and also regulates the development of a TH1 (show HAND1 Proteins) T-cell response.

  8. LAG-3 exerts an important regulatory effect on autoimmunity.

  9. Lag-3 is an important regulatory molecule involved in alloreactive T cell proliferation and activation after bone marrow transplantation.

  10. these results define a strong synergy between the PD-1 (show PDCD1 Proteins) and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens.

Human Lymphocyte-Activation Gene 3 (LAG3) interaction partners

  1. Egr2 (show EGR2 Proteins)-driven cell surface proteins LAG-3 and 4-1BB (show TNFRSF9 Proteins) can identify dysfunctional tumor antigen-specific CD8 (show CD8A Proteins)(+) TIL (show TLR1 Proteins).

  2. our data indicate that the evaluation of stromal TILs remains the most reliable immune prognostic marker in TNBC, and support the clinical evaluation of anti-PD-1 (show PDCD1 Proteins)/PD-L1 (show CD274 Proteins) and anti-LAG-3 in a subset of patients with TNBC who have concurrent expression of both checkpoint receptors.

  3. this review provides the translational rationale for targeting LAG3, as well as historical and current state of clinical trials utilizing LAG3 cancer immunomodulators

  4. this study shows that LAG3 expressed on myeloid leukaemia cells possess the capacity to facilitate functional exhaustion in T helper cells

  5. epigenetic modification on LAG-3 increased LAG-3(+) T cells and its immune regulatory roles in chronic osteomyelitis progression

  6. Immune checkpoint proteins are co-inhibitory factors that can diminish the antigen-specific immune responses by attenuating the regulatory role of cytotoxic T-lymphocyte-associated protein 4 (show CTLA4 Proteins), programmed cell death-1 (show PDCD1 Proteins), lymphocyte-activation gene 3, and T-cell immunoglobulin mucin-3 (show HAVCR2 Proteins).

  7. LAG3 binds alpha-synuclein preformed fibrils (PFF) with high affinity (dissociation constant = 77 nanomolar), whereas the alpha-syn monomer exhibited minimal binding. alpha-Syn-biotin PFF binding to LAG3 initiated alpha-syn PFF endocytosis, transmission, and toxicity.

  8. An IL-27 (show IL27 Proteins)/Lag3 axis enhances Foxp3 (show FOXP3 Proteins)+ regulatory T cell-suppressive function and therapeutic efficacy.

  9. LAG-3 is highly expressed in peripheral blood CD8 (show CD8A Proteins)+ T cells in chronic HBV-infected patients.

  10. Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b (show ITGA2 Proteins) and LAG-3 (CD223) on CD14 (show NDUFA2 Proteins)(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females.

Lymphocyte-Activation Gene 3 (LAG3) Protein Profile

Protein Summary

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Alternative names and synonyms associated with Lymphocyte-Activation Gene 3 (LAG3)

  • lymphocyte-activation gene 3 (LAG3)
  • lymphocyte-activation gene 3 (Lag3)
  • CD223 protein
  • LAG-3 protein
  • Ly66 protein

Protein level used designations for LAG3

lymphocyte-activation gene 3 , lymphocyte-activation protein 3 , lymphocyte-activation protein 3-like , lymphocyte activation gene 3 protein-like , lymphocyte activation gene 3 protein , LAG-3 , lymphocyte activation gene 3

418287 Gallus gallus
451794 Pan troglodytes
515155 Bos taurus
713737 Macaca mulatta
100059998 Equus caballus
100415501 Callithrix jacchus
100452007 Pongo abelii
16768 Mus musculus
3902 Homo sapiens
297596 Rattus norvegicus
100125962 Sus scrofa
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