Quick Overview for LAG3 Protein (Fc Tag) (ABIN7320947)
Target
See all LAG3 ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This LAG3 protein is labelled with Fc Tag.
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Purpose
- Recombinant Cynomolgus LAG-3/CD223 Protein (Fc Tag)
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Sequence
- Ala18-His449(Pro74)
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Characteristics
- Recombinant Cynomolgus LAG-3 Protein is produced by our Mammalian expression system and the target gene encoding Ala18-His449(Pro74) is expressed with a Fc tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (hFc Tag)
LAG3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-434) (Active) protein (Biotin,His-Avi Tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) protein (His tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (His tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 18-449) (Active) protein (Fc Tag)LAG3 Origin: Cynomolgus Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) (Active) protein (His tag)LAG3 Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) (Active) protein (His tag)LAG3 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-222) protein (His-IF2DI Tag)LAG3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) protein (Fc Tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution ofPBS, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
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Alternative Name
- LAG-3/CD223
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Background
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Background: Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Synonym: Lymphocyte activation gene 3 protein,LAG3,LAG-3,Protein FDC,CD223
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Molecular Weight
- 73.6 kDa
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NCBI Accession
- XP_005570011
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Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
Target
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