LAG3 Protein (AA 18-449) (Fc Tag)
(1 reference)Quick Overview for LAG3 Protein (AA 18-449) (Fc Tag) (ABIN5674617)
Target
See all LAG3 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 18-449
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Purification tag / Conjugate
- This LAG3 protein is labelled with Fc Tag.
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Sequence
- AA 18-449
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Characteristics
- This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 73.7 kDa. The protein migrates as 78-92 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (hFc Tag)
LAG3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-434) (Active) protein (Biotin,His-Avi Tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) protein (His tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (His tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) (Active) protein (His tag)LAG3 Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) protein (Fc Tag)LAG3 Origin: Cynomolgus Host: Human Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Lymphocyte-Activation Gene 3 (LAG3) (Active) protein (His tag)LAG3 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-222) protein (His-IF2DI Tag)LAG3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) protein (Fc Tag)LAG3 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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: "Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy." in: mAbs, Vol. 11, Issue 6, pp. 1139-1148, (2019) (PubMed).
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: "Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy." in: mAbs, Vol. 11, Issue 6, pp. 1139-1148, (2019) (PubMed).
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- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
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Alternative Name
- LAG-3
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Background
- Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.
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Molecular Weight
- 73.5 kDa
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NCBI Accession
- XP_005570011
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Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
Target
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