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Browse our NCR1 Proteins (NCR1)

Full name:
Natural Cytotoxicity Triggering Receptor 1 Proteins (NCR1)
On are 20 Natural Cytotoxicity Triggering Receptor 1 (NCR1) Proteins from 10 different suppliers available. Additionally we are shipping NCR1 Antibodies (227) and NCR1 Kits (9) and many more products for this protein. A total of 266 NCR1 products are currently listed.
CD335, KILR-1, Ly94, Nk-p46, Nkp46
list all proteins Gene Name GeneID UniProt
NCR1 9437 O76036
NCR1 17086 Q8C567
NCR1 117547 Q9Z0H5

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NCR1 Proteins (NCR1) by Origin

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Top referenced NCR1 Proteins

  1. Human NCR1 Protein expressed in HEK-293 Cells - ABIN2181529 : Pessino, Sivori, Bottino, Malaspina, Morelli, Moretta, Biassoni, Moretta: Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. in The Journal of experimental medicine 1998 (PubMed)

More Proteins for NCR1 Interaction Partners

Human Natural Cytotoxicity Triggering Receptor 1 (NCR1) interaction partners

  1. Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals.

  2. Taken together, these results demonstrate that endogenous levels of IFN-alpha (show IFNA Proteins) secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4 (show CD4 Proteins)+ primary T cells via the engagement of NKp46 and NKG2D (show KLRK1 Proteins).

  3. NKp46 was thus involved in the production of serine proteases and interleukin-22 (show IL22 Proteins) in human mast cells.

  4. Age and CMV serostatus influence the expression of NKp30 (show NCR3 Proteins), NKp46 and DNAM-1 (show CD226 Proteins) activating receptors on resting and IL-2 (show IL2 Proteins) activated natural killer cells.

  5. Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios (show ZNFN1A2 Proteins) expression

  6. Data show that regulatory dendritic cells (regDC) restrain IFN-gamma (show IFNG Proteins) secretion by NK cells through secretion of interleukin-10 (IL-10 (show IL10 Proteins)), engagement of MHC class I-specific inhibitory receptors, and the activating receptor NKp46.

  7. Expression of NKp46/NCR1 in NK cells was significantly higher in untreated severe aplastic anemia patients than those in remission SAA (show SAA1 Proteins) and controls. This may be the reason for the hyperfunction of the immune system in SAA (show SAA1 Proteins) patients.

  8. On CD56 (show NCAM1 Proteins)(+) CD3 (show CD3 Proteins)(-) cells, NKp44 (show NCR2 Proteins) and NKp46 expressions were high in the acute hepatitis E patients, whereas NKp30 (show NCR3 Proteins), NKp44 (show NCR2 Proteins), NKp46 and NKG2D (show KLRK1 Proteins) were high in the recovered individuals.

  9. Downregulated NKG2D (show KLRK1 Proteins), NKp46, and DNAM-1 (show CD226 Proteins) receptors associated with impaired NK cell effector function are important biomarkers of advanced disease with a poor prognosis in melanoma patients.

  10. Women, w/ or w/o endometriosis, having larger populations of cytotoxic CD16 (show CD16 Proteins)(+) uterine NK cells and/or higher populations of NKp46(+)CD56 (show NCAM1 Proteins)(+) cells may be at greater risk of infertility resulting from inflammatory environment during implantation or later

Mouse (Murine) Natural Cytotoxicity Triggering Receptor 1 (NCR1) interaction partners

  1. Rag knockout mice that possess fully functional NKp46(+) cells

  2. Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios (show ZNFN1A2 Proteins) expression

  3. NK cell receptor (show KLRD1 Proteins) NKp46 regulates graft-versus-host disease.

  4. Ifnar1 (show IFNAR1 Proteins)(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack.

  5. Data from knockout/transgenic mice suggest that activation of Ncr1 by endogenous (as yet undefined) ligands contributes to activation/maturation of uterine natural killer cells and likely makes critical contributions to implantation/placentation.

  6. Here, we demonstrate the regulation of T-cell mediated allergic responses, which is dependent on the NK-cell specific receptor NKp46 (Ncr1 in mice).

  7. NKp46 deficiency alone, or in combination with NKG2D (show KLRK1 Proteins) deficiency, had no effect on frequency or function of NK cells

  8. NCR1 and NKp46 directly recognize a periodontal pathogen.

  9. NKp46/NCR1 plays an important role in controlling neoplasm metastasis

  10. downregulation of NK activity by NKp46 associated with silencing of Helios (show ZNFN1A2 Proteins) in NK cells; NKp46 critical for development of antiviral and antibacterial T cell response

NCR1 Protein Profile

Protein Summary

has similarity to immunoglobulins\; expressed in NK cells

Alternative names and synonyms associated with NCR1

  • natural cytotoxicity triggering receptor 1 (NCR1)
  • natural cytotoxicity triggering receptor 1 (Ncr1)
  • CD335 protein
  • KILR-1 protein
  • Ly94 protein
  • Nk-p46 protein
  • Nkp46 protein

Protein level used designations for NCR1

NK cell-activating receptor , lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46) , natural killer cell p46-related protein , MAR1 (mouse activating receptor 1) , NK-p46 , activating receptor 1 , lymphocyte antigen 94 , mAR-1 , mNKp46 , NK receptor KILR-1 , NK-p46) , NKACTR , lymphocyte antigen 94 homolog (activating NK-receptor , rAR-1 , rat-activating receptor 1

9437 Homo sapiens
17086 Mus musculus
117547 Rattus norvegicus
611390 Canis lupus familiaris
100141419 Sus scrofa
369024 Bos taurus
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