NCR1 Protein (AA 22-257) (His tag,AVI tag,Biotin)

Catalog No. ABIN6973180

Product Details

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 22-257

Origin: Cynomolgus

Source: HEK-293 Cells

Purification tag / Conjugate: This NCR1 protein is labelled with His tag,AVI tag,Biotin.

Specificity: Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

Characteristics: Biotinylated Cynomolgus NKp46 / NCR1 / CD335 Protein, His,Avitag™ (MALS verified)

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Application Notes: MALS verified

Comment:

Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Alternative Name: NKp46 (NCR1 Products)

Synonyms: CD335 Protein, LY94 Protein, NK-p46 Protein, NKP46 Protein, Ly94 Protein, NKp46 Protein, KILR-1 Protein, Nk-p46 Protein, Nkp46 Protein, natural cytotoxicity triggering receptor 1 Protein, NCR1 Protein, Ncr1 Protein

Background: Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Molecular Weight: 30.3 kDa

NCBI Accession: NP_001271509

Pathways: Regulation of Leukocyte Mediated Immunity