Browse our MBNL1 Proteins (MBNL1)

Full name:
Muscleblind-Like (Drosophila) Proteins (MBNL1)
On www.antibodies-online.com are 13 Muscleblind-Like (Drosophila) (MBNL1) Proteins from 4 different suppliers available. Additionally we are shipping MBNL1 Antibodies (116) and MBNL1 Kits (3) and many more products for this protein. A total of 136 MBNL1 products are currently listed.
Synonyms:
EXP, EXP35, EXP40, EXP42, MBNL, MBNL1, mKIAA0428, zgc:153954
list all proteins Gene Name GeneID UniProt
MBNL1 56758 Q9JKP5
MBNL1 4154 Q9NR56
Rat MBNL1 MBNL1 282635  

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MBNL1 Proteins (MBNL1) by Origin

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Top referenced MBNL1 Proteins

  1. Human MBNL1 Protein expressed in HEK-293 Cells - ABIN2725584 : Echeverria, Cooper: Muscleblind-like 1 activates insulin receptor exon 11 inclusion by enhancing U2AF65 binding and splicing of the upstream intron. in Nucleic acids research 2014 (PubMed)

More Proteins for MBNL1 Interaction Partners

Mouse (Murine) Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. Data show that Muscleblind-like 1 (Mbnl1) and Muscleblind-Like 3 (Mbnl3 (show MBNL3 Proteins)) bind skeletal muscle chloride channel (show CLCA1 Proteins) CIC-1 (Clc-1 (show CLCN1 Proteins)) mRNA.

  2. Depletion of Mbnl1 and/or Mbnl2 (show MBNL2 Proteins) reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  3. Sense DMPK (show DMPK Proteins) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Proteins) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  4. MBNL1 overexpression promotes transformation of fibroblasts into myofibroblasts.

  5. These data indicate that MBNL1 plays a conserved role in negatively regulating TGFbeta (show TGFB1 Proteins) signaling, and is required for normal valve morphogenesis and homeostasis in vivo.

  6. this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.

  7. Differential expression of Mbnl1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.

  8. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

  9. depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  10. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

Human Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. Our work suggests that DM1 (show DMPK Proteins) patients are at risk for Fuchs' endothelial corneal dystrophy (FECD (show COL8a2 Proteins)). DMPK (show DMPK Proteins) mutations contribute to the genetic burden of FECD (show COL8a2 Proteins) but are uncommon. We establish a connection between two repeat expansion disorders converging upon RNA-MBNL1 foci and FECD (show COL8a2 Proteins).

  2. Binding of the MBNL zinc fingers to cardiac troponin T (show TNNT2 Proteins) pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.

  3. Heterozygous missense mutations and one in-frame deletion in MBNL1 were identified in 3 myotonic dystrophy patients.

  4. Nuclear retention of full-length HTT (show HTT Proteins) RNA is mediated by splicing factors MBNL1 and U2AF65 (show U2AF59 Proteins)

  5. muscleblind-like 1 (MBNL1) is a robust suppressor of multiorgan breast cancer metastasis. It binds the 3' untranslated regions of DBNL (show DBNL Proteins) and TACC1 (show TACC1 Proteins) -two genes that are implicated as metastasis suppressors.

  6. Sense DMPK (show DMPK Proteins) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Proteins) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  7. abnormal splicing of DMD (show DMD Proteins) exon 78 found in dystrophic muscles of DM1 (show DMPK Proteins) patients is due to the functional loss of MBNL1 and leads to the re-expression of an embryonic dystrophin (show DMD Proteins) in place of the adult isoform.

  8. Reduced RBFOX1 (show A2BP1 Proteins) activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.

  9. MBNL1 binds with C allelic pre-miR (show MLXIP Proteins)-1307 leading to low expression of miR (show MLXIP Proteins)-1307-3p in colorectal cancer.

  10. The result is consistent with the hypothesis that MBNL proteins are trapped by expanded CUG repeats and inactivated in myotonic dystrophy type 1 (DM1) and that CELF1 is activated in DM1.

MBNL1 Protein Profile

Protein Summary

Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).

Alternative names and synonyms associated with MBNL1

  • muscleblind-like (Drosophila) (MBNL1)
  • muscleblind-like (Drosophila) (mbnl1)
  • muscleblind-like 1 (Drosophila) (Mbnl1)
  • muscleblind-like splicing regulator 1 (MBNL1)
  • muscleblind-like splicing regulator 1 (Mbnl1)
  • EXP protein
  • EXP35 protein
  • EXP40 protein
  • EXP42 protein
  • MBNL protein
  • MBNL1 protein
  • mKIAA0428 protein
  • zgc:153954 protein

Protein level used designations for MBNL1

muscleblind-like , muscleblind-like (Drosophila) , muscleblind-like protein 1 , muscleblind-like 1 , triplet-expansion RNA-binding protein

GENE ID SPECIES
100218825 Taeniopygia guttata
100559321 Anolis carolinensis
100583541 Nomascus leucogenys
767696 Danio rerio
425033 Gallus gallus
56758 Mus musculus
4154 Homo sapiens
477116 Canis lupus familiaris
781653 Bos taurus
282635 Rattus norvegicus
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