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Browse our ERBB3 Proteins (ERBB3)

Full name:
V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) Proteins (ERBB3)
On www.antibodies-online.com are 43 V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Proteins from 10 different suppliers available. Additionally we are shipping ERBB3 Antibodies (526) and ERBB3 Kits (33) and many more products for this protein. A total of 632 ERBB3 products are currently listed.
Synonyms:
c-erbB-3, c-erbB3, C76256, Erbb-3, ERBB3, erbB3-S, Erbb3r, Her3, LCCS2, MDA-BF-1, nuc-ErbB3, p45-sErbB3, p85-sErbB3, p180-ErbB3
list all proteins Gene Name GeneID UniProt
ERBB3 2065 P21860
ERBB3 29496 Q62799
ERBB3 13867 Q61526

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ERBB3 Proteins (ERBB3) by Origin

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Top referenced ERBB3 Proteins

  1. Human ERBB3 Protein expressed in Human Cells - ABIN2002328 : Alimandi, Romano, Curia, Muraro, Fedi, Aaronson, Di Fiore, Kraus: Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. in Oncogene 1995 (PubMed)
    Show all 5 references for ABIN2002328

  2. Human ERBB3 Protein expressed in HEK-293 Cells - ABIN2181038 : Singer, Landgraf, Horan, Slamon, Eisenberg: Identification of a heregulin binding site in HER3 extracellular domain. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2181038

  3. Mouse (Murine) ERBB3 Protein expressed in Human Cells - ABIN2008508 : Wallasch, Weiss, Niederfellner, Jallal, Issing, Ullrich: Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. in The EMBO journal 1995 (PubMed)
    Show all 4 references for ABIN2008508

  4. Human ERBB3 Protein expressed in Baculovirus infected Insect Cells - ABIN2002332 : Kraus, Issing, Miki, Popescu, Aaronson: Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 4 references for ABIN2002332

  5. Human ERBB3 Protein expressed in Human Cells - ABIN2002326 : Gamett, Greene, Wagreich, Kim, Koland, Cerione: Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85. in The Journal of biological chemistry 1995 (PubMed)
    Show all 3 references for ABIN2002326

More Proteins for ERBB3 Interaction Partners

Rhesus Monkey V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.

Pig (Porcine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair

Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. Results from circular dichroism spectroscopy, size exclusion chromatography with multiangle light scattering, dynamic light scattering, analytical ultracentrifugation, and small angle X-ray scattering each provide evidence that the EGFR (show EGFR Proteins) and HER3 C-terminal tails are intrinsically disordered with extended, non-globular structure in solution.

  2. YAP (show YAP1 Proteins) induces the expression of epidermal growth factor (EGF (show EGF Proteins)) receptors (EGFR (show EGFR Proteins), ERBB3) and production of EGF (show EGF Proteins)-like ligands (HBEGF (show HBEGF Proteins), NRG1 (show NRG1 Proteins) and NRG2 (show NRG2 Proteins)); YAP (show YAP1 Proteins) induces the expression of epidermal growth factor (EGF (show EGF Proteins)) receptors (EGFR (show EGFR Proteins), ERBB3) and production of EGF (show EGF Proteins)-like ligands (HBEGF (show HBEGF Proteins), NRG1 (show NRG1 Proteins) and NRG2 (show NRG2 Proteins))

  3. the phosphorylation levels of ErbB2 (show ERBB2 Proteins), ErbB3 and Akt (show AKT1 Proteins) and the protein levels of cyclin D1 (show CCND1 Proteins) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 Proteins)-22 cells

  4. In high-grade serous ovarian carcinoma (HGSC), high HER3 mRNA expression was a favorable prognostic factor for survival, while for high HER3 protein expression, a trend towards better survival was seen. A subgroup of HGSC with negative HER3 staining and negative HER3 mRNA levels showed most unfavorable survival.

  5. ERBB3 and ERBB4 (show ERBB4 Proteins) have roles in lung adenocarcinoma

  6. Results suggest that silibinin is a potential anti-cancer drug to inhibit proliferative and invasive characteristics of the epithelial ovarian cancer (EOC) cells that exhibit an autocrine heregulin (HRG (show NRG1 Proteins))/HER3 protein (HRG (show NRG1 Proteins)/HER3) pathway.

  7. findings suggest that HBx promotes the progression of hepatocellular carcinoma by decreasing the stability of Nrdp1 (show RNF41 Proteins), which results in up-regulation of ErbB3

  8. High HER3 expression in colon cancer was associated to distal colon location and low-grade tumor.

  9. Correlate ERBB3 gene SNPs with rheumatoid arthritis susceptibility.

  10. Nrdp1S is a tumour suppressor that which potentiates the Nrdp1 (show RNF41 Proteins)-mediated ubiquitination and degradation of ErbB3. An Nrdp1S deficiency may also be an important factor in the loss of Nrdp1 (show RNF41 Proteins).

Mouse (Murine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. Our results support a role for the hepatocellular ERBB (show EGFR Proteins) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (show EGFR Proteins)-ERBB3 DKO models, suggesting that EGFR (show EGFR Proteins)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (show EGFR Proteins) homodimeric signaling.

  2. nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells

  3. Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 Proteins) protein, epidermal growth factor (EGF (show EGF Proteins)) and receptors of the ErbB (show EGFR Proteins) receptors ErbB1 (show EGFR Proteins), ErbB2 (show ERBB2 Proteins) and ErbB3.

  4. ERBB3 is required for wound healing and for the progression of skin tumors in mice.

  5. The expression of ERBB3 in combination with ERBB4 (show ERBB4 Proteins) significantly amplifies proliferation of lymphocytes upon ligand stimulation.

  6. Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (show AKT1 Proteins) pathway and promoting erbB2 (show ERBB2 Proteins)-driven mammary/breast tumorigenesis.

  7. Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (show STAT3 Proteins) activation.

  8. ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.

  9. ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.

  10. Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.

ERBB3 Protein Profile

Protein Summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Alternative names and synonyms associated with ERBB3

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (Erbb3)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (Erbb3)
  • c-erbB-3 protein
  • c-erbB3 protein
  • C76256 protein
  • Erbb-3 protein
  • ERBB3 protein
  • erbB3-S protein
  • Erbb3r protein
  • Her3 protein
  • LCCS2 protein
  • MDA-BF-1 protein
  • nuc-ErbB3 protein
  • p45-sErbB3 protein
  • p85-sErbB3 protein
  • p180-ErbB3 protein

Protein level used designations for ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) , receptor tyrosine kinase ErbB3 , receptor tyrosine-protein kinase erbB-3-like , proto-oncogene-like protein c-ErbB-3 , receptor tyrosine-protein kinase erbB-3 , tyrosine kinase-type cell surface receptor HER3 , avian erythroblastosis oncogene B 3 , c-erbB-3 , c-erbB3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 , avian erythroblastosis oncogene B 3 receptor , glial growth factor receptor , receptor tyrosine kinase

GENE ID SPECIES
481105 Canis lupus familiaris
711407 Macaca mulatta
100008807 Oryctolagus cuniculus
100126862 Sus scrofa
100468735 Ailuropoda melanoleuca
2065 Homo sapiens
29496 Rattus norvegicus
13867 Mus musculus
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