You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our ERBB3 Proteins (ERBB3)

Full name:
V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) Proteins (ERBB3)
On www.antibodies-online.com are 41 V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Proteins from 10 different suppliers available. Additionally we are shipping ERBB3 Antibodies (498) and ERBB3 Kits (29) and many more products for this protein. A total of 598 ERBB3 products are currently listed.
Synonyms:
c-erbB-3, c-erbB3, C76256, Erbb-3, ERBB3, erbB3-S, Erbb3r, Her3, LCCS2, MDA-BF-1, nuc-ErbB3, p45-sErbB3, p85-sErbB3, p180-ErbB3
list all proteins Gene Name GeneID UniProt
ERBB3 2065 P21860
ERBB3 29496 Q62799
ERBB3 13867 Q61526

Show all synonyms

ERBB3 Proteins (ERBB3) by Origin

Select your origin of interest

Top referenced ERBB3 Proteins

  1. Human ERBB3 Protein expressed in HEK-293 Cells - ABIN2181040 : Alimandi, Romano, Curia, Muraro, Fedi, Aaronson, Di Fiore, Kraus: Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. in Oncogene 1995 (PubMed)
    Show all 5 references for ABIN2181040

  2. Human ERBB3 Protein expressed in Baculovirus infected Insect Cells - ABIN2002332 : Kraus, Issing, Miki, Popescu, Aaronson: Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 4 references for ABIN2002332

  3. Mouse (Murine) ERBB3 Protein expressed in Human Cells - ABIN2008508 : Wallasch, Weiss, Niederfellner, Jallal, Issing, Ullrich: Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. in The EMBO journal 1995 (PubMed)
    Show all 4 references for ABIN2008508

  4. Human ERBB3 Protein expressed in HEK-293 Cells - ABIN2181037 : Singer, Landgraf, Horan, Slamon, Eisenberg: Identification of a heregulin binding site in HER3 extracellular domain. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN2181037

  5. Rhesus Monkey ERBB3 Protein expressed in Human Cells - ABIN2009755 : Gamett, Greene, Wagreich, Kim, Koland, Cerione: Heregulin-stimulated signaling in rat pheochromocytoma cells. Evidence for ErbB3 interactions with Neu/ErbB2 and p85. in The Journal of biological chemistry 1995 (PubMed)
    Show all 3 references for ABIN2009755

More Proteins for ERBB3 Interaction Partners

Rhesus Monkey V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.

Pig (Porcine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair

Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. High HER3 expression in colon cancer was associated to distal colon location and low-grade tumor.

  2. Correlate ERBB3 gene SNPs with rheumatoid arthritis susceptibility.

  3. Nrdp1S is a tumour suppressor that which potentiates the Nrdp1 (show RNF41 Proteins)-mediated ubiquitination and degradation of ErbB3. An Nrdp1S deficiency may also be an important factor in the loss of Nrdp1 (show RNF41 Proteins).

  4. In response to trastuzumab, both HER3 and the metalloprotease (show ADAM8 Proteins) ADAM10 (show ADAM10 Proteins) are simultaneously upregulated. The proteolytic activity of the latter then releases the HER3 ligand heregulin (show NRG1 Proteins) from the cell surface to activate HER3 and confer resistance to trastuzumab by inducing compensatory growth factor receptor (show RYK Proteins) signaling.

  5. the identification of HER3-V855A and its functional properties for the first time clearly implicates genomic HER3 activation in the pathogenesis of lung cancer.

  6. We report that targeting HER3 and b1 integrin provides a particularly effective combination therapy approach for HER2 (show ERBB2 Proteins)-amplified cancers, surpassing the combination of HER2 (show ERBB2 Proteins) and b1 integrin targeting, and evading some of the safety concerns associated with direct HER2 (show ERBB2 Proteins)-targeting.

  7. These data indicate that erbB3 signaling is critical for both trastuzumab and lapatinib resistances mainly through the PI-3K/Akt (show AKT1 Proteins) pathway, whereas IGF-1R (show IGF1R Proteins)-initiated Src (show SRC Proteins) activation results in trastuzumab resistance without affecting lapatinib sensitivity.

  8. Data show that heat shock protein 90 (HSP90 (show HSP90 Proteins)) inhibitor 17-DMAG caused loss of ret proto-oncogene (show RET Proteins) protein (RET (show RET Proteins)) and proto-oncogene (show RAB1A Proteins) protein erbB-3 (ERBB3) phosphorylation and lead to rapid cell death.

  9. Data indicate the role of proto-oncogene (show RAB1A Proteins) protein erbB-3 (ErbB3) in hepatitis B virus X protein (HBx)-mediated cell survival.

  10. NRF2 (show GABPA Proteins) regulates both HER2 (show ERBB2 Proteins) and HER3 receptors to influence cellular responses to HER2 (show ERBB2 Proteins) targeting.

Mouse (Murine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) interaction partners

  1. Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 Proteins) protein, epidermal growth factor (EGF (show EGF Proteins)) and receptors of the ErbB (show EGFR Proteins) receptors ErbB1 (show EGFR Proteins), ErbB2 (show ERBB2 Proteins) and ErbB3.

  2. ERBB3 is required for wound healing and for the progression of skin tumors in mice.

  3. The expression of ERBB3 in combination with ERBB4 (show ERBB4 Proteins) significantly amplifies proliferation of lymphocytes upon ligand stimulation.

  4. Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (show AKT1 Proteins) pathway and promoting erbB2 (show ERBB2 Proteins)-driven mammary/breast tumorigenesis.

  5. Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (show STAT3 Proteins) activation.

  6. ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.

  7. ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.

  8. Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.

  9. Myocilin (show MYOC Proteins) binds to ErbB2 (show ERBB2 Proteins)/ErbB3, activates these receptors, and affects the downstream PI3K-AKT (show AKT1 Proteins) signaling pathway

  10. PIK3CA (show PIK3CA Proteins)(H1047R)-driven tumor growth and PI3K signaling can occur independently of ErbB3 receptor tyrosine kinases.

ERBB3 Protein Profile

Protein Summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Alternative names and synonyms associated with ERBB3

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (ERBB3)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (Erbb3)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (Erbb3)
  • c-erbB-3 protein
  • c-erbB3 protein
  • C76256 protein
  • Erbb-3 protein
  • ERBB3 protein
  • erbB3-S protein
  • Erbb3r protein
  • Her3 protein
  • LCCS2 protein
  • MDA-BF-1 protein
  • nuc-ErbB3 protein
  • p45-sErbB3 protein
  • p85-sErbB3 protein
  • p180-ErbB3 protein

Protein level used designations for ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) , receptor tyrosine kinase ErbB3 , receptor tyrosine-protein kinase erbB-3-like , proto-oncogene-like protein c-ErbB-3 , receptor tyrosine-protein kinase erbB-3 , tyrosine kinase-type cell surface receptor HER3 , avian erythroblastosis oncogene B 3 , c-erbB-3 , c-erbB3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 , avian erythroblastosis oncogene B 3 receptor , glial growth factor receptor , receptor tyrosine kinase

GENE ID SPECIES
481105 Canis lupus familiaris
711407 Macaca mulatta
100008807 Oryctolagus cuniculus
100126862 Sus scrofa
100468735 Ailuropoda melanoleuca
2065 Homo sapiens
29496 Rattus norvegicus
13867 Mus musculus
Selected quality suppliers for ERBB3 Proteins (ERBB3)
Did you look for something else?