ERBB3 Protein (AA 20-643) (His tag,AVI tag,Biotin)
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- Target See all ERBB3 Proteins
- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 20-643
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ERBB3 protein is labelled with His tag,AVI tag,Biotin.
- Sequence
- AA 20-643
- Specificity
- Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
- Purity
- >95 % as determined by reduced SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ERBB3 Protein
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- Comment
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Ready-to-use AvitagTM biotinylated protein:
The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.
This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled. - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
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- Target
- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
- Alternative Name
- ErbB3 (ERBB3 Products)
- Synonyms
- ErbB-3 Protein, HER3 Protein, LCCS2 Protein, MDA-BF-1 Protein, c-erbB-3 Protein, c-erbB3 Protein, erbB3-S Protein, p180-ErbB3 Protein, p45-sErbB3 Protein, p85-sErbB3 Protein, ERBB3 Protein, C76256 Protein, Erbb-3 Protein, Erbb3r Protein, Her3 Protein, nuc-ErbB3 Protein, erb-b2 receptor tyrosine kinase 3 Protein, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Protein, ERBB3 Protein, Erbb3 Protein
- Background
- ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
- Molecular Weight
- 72.4 kDa
- NCBI Accession
- NP_001973
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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